Association of Brain‐Derived Neurotrophic Factor rs6265 G&gt;A polymorphism and Post‐traumatic Stress Disorder susceptibility: A systematic review and meta‐analysis

Hu, X Z; Wu, None Yu‐Long; Cheng, Chao-Hui; Liu, Xiaoxi; Zhou, Lan

doi:10.1002/brb3.2118

Cited by 5 publications

(1 citation statement)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The processes involved in the pathogenesis of PTSD are complex, involving interactions between genetic vulnerability, exposure to stress or trauma in early life, and the nature and severity of the specific trauma exposure triggering the disorder [15][16][17][18][19][20]. These interactions may, in turn, be moderated by protective factors, which can be either individual or social [21].…”

Section: Introductionmentioning

confidence: 99%

Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review

Rajkumar

2023

Biomedicines

View full text Add to dashboard Cite

Post-Traumatic Stress Disorder (PTSD) is a chronic psychiatric disorder that occurs following exposure to traumatic events. Recent evidence suggests that PTSD may be a risk factor for the development of subsequent neurodegenerative disorders, including Alzheimer’s dementia and Parkinson’s disease. Identification of biomarkers known to be associated with neurodegeneration in patients with PTSD would shed light on the pathophysiological mechanisms linking these disorders and would also help in the development of preventive strategies for neurodegenerative disorders in PTSD. With this background, the PubMed and Scopus databases were searched for studies designed to identify biomarkers that could be associated with an increased risk of neurodegenerative disorders in patients with PTSD. Out of a total of 342 citations retrieved, 29 studies were identified for inclusion in the review. The results of these studies suggest that biomarkers such as cerebral cortical thinning, disrupted white matter integrity, specific genetic polymorphisms, immune-inflammatory alterations, vitamin D deficiency, metabolic syndrome, and objectively documented parasomnias are significantly associated with PTSD and may predict an increased risk of subsequent neurodegenerative disorders. The biological mechanisms underlying these changes, and the interactions between them, are also explored. Though requiring replication, these findings highlight a number of biological pathways that plausibly link PTSD with neurodegenerative disorders and suggest potentially valuable avenues for prevention and early intervention.

show abstract

Section: Introductionmentioning

confidence: 99%

Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review

Rajkumar

2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Association of Brain‐Derived Neurotrophic Factor rs6265 G>A polymorphism and Post‐traumatic Stress Disorder susceptibility: A systematic review and meta‐analysis

Cheng

et al. 2021

Brain and Behavior

Self Cite

View full text Add to dashboard Cite

Background Previous studies have shown that the brain‐derived neurotrophic factor (BDNF) rs6265 G > A polymorphism is closely related post‐traumatic stress disorder (PTSD) risk. However, the results were not consistent. We therefore conducted a meta‐analysis to explore the underlying relationships between BDNF rs6265 G > A polymorphism and PTSD risk. Materials and Methods Five online databases were searched, and all related studies were reviewed up to July 1, 2020. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to examine the statistical power of each genetic model. In addition, heterogeneity, sensitivity accumulative analysis, and publication bias were examined to check the statistical power. Result Overall, 16 publications involving 5,369 subjects were included in this systematic review and 11 case‐control studies were analyses in meta‐analysis. The pooled results indicated an increasing risk of A allele mutations with PTSD risk. Moreover, the sequential subgroup analysis also demonstrated some similar situations in Asian populations and other groups. Conclusion Current meta‐analysis suggests that the BDNF rs6265 G > A polymorphism might be involved in PTSD susceptibility.

show abstract

The BDNF Protein is Associated With Glucose Homeostasis and Food Intake in Carriers of Common BDNF Gene Variants

Miksza,

Bauer,

Roszkowska

et al. 2024

The Journal of Clinical Endocrinology &Amp; Metabolism

View full text Add to dashboard Cite

Context The brain-derived neurotrophic factor (BDNF) concentrations may differ between BDNF gene genotype carriers. These changes occur in individuals with metabolic and mental disorders. Objective The aim of this study was to assess the associations of glucose homeostasis parameters and the frequency of food consumption with BDNF protein concentrations based on the BDNF single-nucleotide polymorphisms (SNPs). Methods Among the 439 participants, some common rs10835211 BDNF gene variants were analyzed. We evaluated BDNF concentration, fasting glucose and insulin concentrations and during oral glucose tolerance tests. Anthropometric measurements, body composition, and body fat distribution were assessed, and 3-day food intake diary and food frequency questionnaire were completed. Results We noticed significant differences in concentration of BDNF between AA and AG genotype rs10835211 carriers (p=0.018). The group of AA genotype holders were older, and positive correlation was found between age and BDNF in the whole study population (p=0.012) and in the GG genotype carriers (p=0.023). Moreover, BDNF protein correlated with fasting insulin (p=0.015), HOMA-IR (p=0.031), HOMA-B (p=0.010) , and the VAT/SAT ratio (p=0.026) in the GG genotype individuals. Presence of the GG genotype was negatively correlated with nut and seed (p=0.047), lean pork consumption (p=0.015) and the BDNF protein. Moreover, we observed correlations between the frequency of chicken (p=0.028), pasta (p=0.033) and sweet food intake (p=0.040) and BDNF concentration in the general population. Among carriers of the AA genotype, we observed a positive correlation between the consumption of rice (p=0.048) and sweet food (p=0.028) and the BDNF protein level. Conclusion Peripheral BDNF may be associated with visceral fat content and insulin concentrations in the GG genotype carriers and may depend on variable food intake, which warrants further investigation.

show abstract

Association of Brain‐Derived Neurotrophic Factor rs6265 G>A polymorphism and Post‐traumatic Stress Disorder susceptibility: A systematic review and meta‐analysis

Cited by 5 publications

References 61 publications

Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review

Biomarkers of Neurodegeneration in Post-Traumatic Stress Disorder: An Integrative Review

Association of Brain‐Derived Neurotrophic Factor rs6265 G>A polymorphism and Post‐traumatic Stress Disorder susceptibility: A systematic review and meta‐analysis

The BDNF Protein is Associated With Glucose Homeostasis and Food Intake in Carriers of Common BDNF Gene Variants

Contact Info

Product

Resources

About