Association of Body Weight Variability With Progression of Coronary Artery Calcification in Patients With Predialysis Chronic Kidney Disease

Suh, Sang Heon; Oh, Tae Ryom; Choi, Hong Sang; Kim, Chang Seong; Bae, Eun Hui; Oh, Kook‐Hwan; Lee, Kyu‐Beck; Han, Seung Hyeok; Sung, Suah; Kwon, Seong; Kim, Soo Wan

doi:10.3389/fcvm.2021.794957

Cited by 4 publications

(4 citation statements)

References 37 publications

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“…If con rmed in a larger number of patients, CLS density could be an important predictive tool for cardiovascular diseases. Furthermore, the LS case outlines the importance of timing in weight gain as recently described also by another study [15].…”

Section: Discussionmentioning

confidence: 55%

The density of Crown-Like Structures in epicardial adipose tissue could play a role in cardiovascular diseases

Malavazos

Vincenzo

Iacobellis

et al. 2022

Preprint

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Purpose The visceral fat of patients affected by abdominal obesity is inflamed, and the main histopathologic feature is the high density of crown-like structures (CLS). Epicardial adipose tissue (EAT) is a visceral fat of paramount importance for its relationships with coronary vessels and myocardium. Its inflammation in patients with abdominal obesity could be of clinical relevance, but histopathological studies on CLS density in EAT are lacking. This study aimed to assess the histopathology of EAT biopsies obtained from patients undergoing open-heart surgery. Methods We collected EAT biopsies from 10 patients undergoing open-heart surgery for elective coronary artery bypass grafting (CABG) (n=5) or valvular replacement (VR) (n=5). Biopsies were treated for light microscopy and immunohistochemistry. We quantify the CLS density in each EAT sample. Results Despite all patients having abdominal obesity, in EAT samples, no CLS were detected in the VR group; in contrast, CLS were detected in the CABG group (about 17 CLS/104 adipocytes vs. 0,0 CLS/104 adipocytes, CABG vs. VR group, respectively). An impressive density of CLS (100 times that of other patients) was found in one patient (LS) in the CABG group that had a relevant anamnestic aspect: relatively rapid increase of weight gain, especially in abdominal adipose tissue, coincident with myocardial infarction. Conclusion CLS density could be an important predictive tool for cardiovascular diseases. Furthermore, the LS case implies a role for timing in weight gain.Level of evidence: No level of evidence; this is a basic science study.

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Section: Discussionmentioning

confidence: 55%

The density of Crown-Like Structures in epicardial adipose tissue could play a role in cardiovascular diseases

Malavazos

Vincenzo

Iacobellis

et al. 2022

Preprint

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show abstract

“…Furthermore, the LS case outlines the importance of An impressive amount of classic CLS (single and groups) are visible (arrows, some indicated). Bar: 30 μm timing in weight gain as recently described also by another study [17].…”

Section: Discussionmentioning

confidence: 62%

The density of crown-like structures in epicardial adipose tissue could play a role in cardiovascular diseases

et al. 2022

View full text Add to dashboard Cite

Purpose The visceral fat of patients affected by abdominal obesity is inflamed, and the main histopathologic feature is the high density of crown-like structures (CLS). Epicardial adipose tissue (EAT) is a visceral fat of paramount importance for its relationships with coronary vessels and myocardium. Its inflammation in patients with abdominal obesity could be of clinical relevance, but histopathological studies on CLS density in EAT are lacking. This study aimed to assess the histopathology of EAT biopsies obtained from patients undergoing open-heart surgery. Methods We collected EAT biopsies from 10 patients undergoing open-heart surgery for elective coronary artery bypass grafting (CABG) (n = 5) or valvular replacement (VR) (n = 5). Biopsies were treated for light microscopy and immunohistochemistry. We quantify the CLS density in each EAT sample. Results Despite all patients having abdominal obesity, in EAT samples, no CLS were detected in the VR group; in contrast, CLS were detected in the CABG group (about 17 CLS/10 4 adipocytes vs. 0.0 CLS/10 4 adipocytes, CABG vs. VR group, respectively). An impressive density of CLS (100 times that of other patients) was found in one patient (LS) in the CABG group that had a relevant anamnestic aspect: relatively rapid increase of weight gain, especially in abdominal adipose tissue, coincident with myocardial infarction. Conclusions CLS density could be an important predictive tool for cardiovascular diseases. Furthermore, the LS case implies a role for timing in weight gain. Level of evidence No level of evidence; this is a basic science study.

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“…T1, T2, and T3 were defined as low, moderate, and high urinary chloride excretion, respectively. The study outcome was progression of CAC, which was defined as increase in CACS of more than 200 AU during the 4-year follow-up period, as in previously published studies from KNOW-CKD [21][22][23].…”

Section: Exposure and Study Outcomementioning

confidence: 99%

Association between urinary chloride excretion and progression of coronary artery calcification in patients with nondialysis chronic kidney disease: results from the KNOW-CKD study

Suh¹,

Oh²,

Choi³

et al. 2023

Kidney Res Clin Pract

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Background: Urine chloride has recently been suggested as a biomarker of renal tubule function in patients with nondialysis chronic kidney disease (CKD), as low urinary chloride concentration is associated with an increased risk of CKD progression. We investigate the association between urinary chloride excretion and the progression of coronary artery calcification (CAC). Methods: A total of 1,065 patients with nondialysis CKD were divided into tertiles by spot urine chloride-to-creatinine ratios. The 1st, 2nd, and 3rd tertiles were defined as low, moderate, and high urinary chloride excretion, respectively. The study outcome was CAC progression, which was defined as an increase in coronary artery calcium score of more than 200 Agatston units during the 4-year follow-up period. Results: Compared to moderate urinary chloride excretion, high urinary chloride excretion was associated with decreased risk of CAC progression (adjusted odds ratio, 0.379; 95% confidence interval, 0.190–0.757), whereas low urinary chloride excretion was not associated with risk of CAC progression. Restricted cubic spine depicted an inverted J-shaped curve, with a significant reduction in the risk of CAC progression in subjects with high spot urine chloride-to-creatinine ratios. Conclusion: High urinary chloride excretion is associated with decreased risk of CAC progression in patients with nondialysis CKD.

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Association of Body Weight Variability With Progression of Coronary Artery Calcification in Patients With Predialysis Chronic Kidney Disease

Cited by 4 publications

References 37 publications

The density of Crown-Like Structures in epicardial adipose tissue could play a role in cardiovascular diseases

The density of Crown-Like Structures in epicardial adipose tissue could play a role in cardiovascular diseases

The density of crown-like structures in epicardial adipose tissue could play a role in cardiovascular diseases

Association between urinary chloride excretion and progression of coronary artery calcification in patients with nondialysis chronic kidney disease: results from the KNOW-CKD study

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