Association of body mass index with mortality and postoperative survival in renal cell cancer patients, a meta-analysis

Abstract

Obesity is one of the major risk factors of cancer. However, how body mass index (BMI) influences the prognosis of renal cell cancer (RCC) patient is unclear. In this work, we have performed a meta-analysis to elucidate the role of abnormal weight in RCC mortality and postoperative survival. Articles related to BMI and RCC mortality as well as postoperative survival has been identified by searching PUBMED and ENBASE. Totally, 19 articles have been selected for this meta-analysis, 5 articles for RCC mortality and 14 for postoperative survival. Compared to normal weight, the estimated relative risks of RCC mortality are 0.71 (95% CI: 0.34–1.49), 1.19 (95% CI: 1.05–1.35) and 1.71 (95% CI: 1.27–2.00) respectively for the underweight, overweight and obesity patients. The risk of RCC mortality increase 5% for each 1 kg/m2 increment of BMI. However, the estimated hazard ratios of cancer specific postoperative survival are 2.62 (95% CI: 1.67–4.11), 0.72 (95% CI: 0.63–0.83) and 0.66 (95% CI: 0.49–0.89) respectively for underweight, overweight and obesity RCC patients. The risk of hazard ratio decrease 5% for each 1 kg/m2 increment of BMI. In addition, the hazard ratios of postoperative overall survival show a similar tendency. These results indicate an opposite association of BMI with mortality and postoperative survival in renal cell cancer patients.

<p>Prognostic significance of combined pretreatment body mass index (BMI) and BMI loss in patients with esophageal cancer</p>

“…We found that the 10 year OS of patients with a high BMI were significantly longer than patients with a low BMI, which was true for both the entire cohort and the ESCC group. This result was consistent with previous studies in both benign tumors22–25 and malignant tumors 12,26–33. Although there have been studies that investigated the relationship between esophageal cancer and BMI,12,16,34–39 these studies primarily focused on operative squamous cell carcinoma, esophageal adenocarcinoma, or patients only treated with adjuvant therapy.…”

Impact of Body Composition in Overweight and Obese Patients With Localised Renal Cell Carcinoma

“…These results support the "obesity paradox" in RCC and the idea that a high BMI is associated with significantly longer cancer-specific survival (30,31). A recent meta-analysis highlighted the opposite association between BMI and mortality in patients with RCC (32). In this subgroup of obese patients, sarcopenia seemed to be a poor prognosis factor, as shown previously (33).…”

Process Optimization for Improved Phenolic Compounds Recovery from Walnut (Juglans regia L.) Septum: Phytochemical Profile and Biological Activities

“…Processed food, the so called “junk food”, with high content of carbohydrates, fats, and salt, is linked to overweight and obesity via several mechanisms [ 4 ]. Excessive body weight, associated with several pro-inflammatory cytokines (e.g., leptin, interleukin 6, interleukin 8, tumor necrosis factor-alpha), and a chronic, low-grade inflammation [ 5 ], is seen as a major risk factor for obesity-associated diseases, such as metabolic dysfunction [ 6 ], diabetes [ 7 ], cardiovascular diseases [ 8 ], and cancers [ 9 ], including endometrial [ 10 ], breast [ 11 ], gastrointestinal [ 12 ], pancreatic [ 13 ], prostate [ 14 ], hepatic [ 15 ], renal [ 16 ], colorectal [ 17 ].…”