Association of Body Mass Index and Waist-to-Hip Ratio With Retinal Microvasculature in Healthy Chinese Adults: An Optical Coherence Tomography Angiography Study

Ding, Qiong; Wu, Huimin; Wang, Wei; Xiong, Kun; Gong, Xia; Yuan, Guiliang; Li, Tengchao; Li, Youjia; Liu, Hua; Wang, Lanhua; Huang, Wenyong

doi:10.1016/j.ajo.2022.09.012

Cited by 4 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This may not have happened by chance, as it has already been well established that obesity is a risk factor for a more severe course of the disease 52 – 54 . A recently conducted study found a positive association between BMI and vessel density in the SVP in healthy Chinese adults 55 . In our study, no difference in vessel density in the SVP between the two groups was found although BMI was significantly higher in the COVID-19 group, as mentioned above.…”

Section: Discussionmentioning

confidence: 97%

Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients

Pai,

Bileck,

Hommer

et al. 2024

Sci Rep

View full text Add to dashboard Cite

The aim of the present study was to investigate retinal microcirculatory and functional metabolic changes in patients after they had recovered from a moderate to severe acute COVID-19 infection. Retinal perfusion was quantified using laser speckle flowgraphy. Oxygen saturation and retinal calibers were assessed with a dynamic vessel analyzer. Arterio-venous ratio (AVR) was calculated based on retinal vessel diameter data. Blood plasma samples underwent mass spectrometry-based multi-omics profiling, including proteomics, metabolomics and eicosadomics. A total of 40 subjects were included in the present study, of which 29 had recovered from moderate to severe COVID-19 within 2 to 23 weeks before inclusion and 11 had never had COVID-19, as confirmed by antibody testing. Perfusion in retinal vessels was significantly lower in patients (60.6 ± 16.0 a.u.) than in control subjects (76.2 ± 12.1 a.u., p = 0.006). Arterio-venous (AV) difference in oxygen saturation and AVR was significantly lower in patients compared to healthy controls (p = 0.021 for AVR and p = 0.023 for AV difference in oxygen saturation). Molecular profiles demonstrated down-regulation of cell adhesion molecules, NOTCH3 and fatty acids, and suggested a bisphasic dysregulation of nitric oxide synthesis after COVID-19 infection. The results of this study imply that retinal perfusion and oxygen metabolism is still significantly altered in patients well beyond the acute phase of COVID-19. This is also reflected in the molecular profiling analysis of blood plasma, indicating a down-regulation of nitric oxide-related endothelial and immunological cell functions.Trial Registration: ClinicalTrials.gov (https://clinicaltrials.gov) NCT05650905.

show abstract

Section: Discussionmentioning

confidence: 97%

Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients

Pai,

Bileck,

Hommer

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The results of a cross-sectional study of 1555 Chinese adults aged ≥ 50 years with no history of ocular disease showed that BMI and waist-to-hip ratio are positively associated with increased macular vessel density (VD) on optical coherence tomography angiography, both in the superficial capillary plexus and deep capillary plexus. The different manifestations of retinal microvascularization may therefore reflect the distinct effects of body composition on macular vessel alterations and disease onset [ 93 ].…”

Section: Obesity and Eye Diseasesmentioning

confidence: 99%

Obesity, body fat distribution and eye diseases

Bosello,

Vanzo,

Zaffalon

et al. 2024

Eat Weight Disord

View full text Add to dashboard Cite

Background The prevalence of obesity, a chronic disease, is increasing, and obesity is now considered a global epidemic. Eye diseases are also increasing worldwide and have serious repercussions on quality of life as well as increasingly high costs for the community. The relationships between obesity and ocular pathologies are not yet well clarified and are not pathologically homogeneous: they seem to be somehow linked to excess body fat, especially to the distribution of adipose tissue and its ectopic deposits. Purpose Our objective was to examine the associations between obesity and anthropometric indices, including body mass index (BMI), waist circumference (WC), and the waist/hip ratio (WHR), and the risk of most widespread eye diseases, with particular attention given to the most significant metabolic mechanisms. Methods This article provides a narrative overview of the effect of obesity and anthropometric measurements of body fat on prevalent eye diseases. We used the MEDLINE/PubMed, CINAHL, EMBASE, and Cochrane Library databases from 1984 to 2024. In addition, we hand-searched references from the retrieved articles and explored a number of related websites. A total of 153 publications were considered. Results There is significant evidence that obesity is associated with several eye diseases. Waist circumference (WC) and the waist/hip ratio (WHR) have been observed to have stronger positive associations with eye diseases than BMI. Conclusions Obesity must be considered a significant risk factor for eye diseases; hence, a multidisciplinary and multidimensional approach to treating obesity, which also affects ocular health, is important. In the prevention and treatment of eye diseases related to obesity, lifestyle factors, especially diet and physical activity, as well as weight changes, both weight loss and weight gain, should not be overlooked. Level of evidence Level V narrative review.

show abstract

Retinal microcirculation: A window into systemic circulation and metabolic disease

Yuan,

Dong,

Wen

et al. 2024

Experimental Eye Research

View full text Add to dashboard Cite

Association of Body Mass Index and Waist-to-Hip Ratio With Retinal Microvasculature in Healthy Chinese Adults: An Optical Coherence Tomography Angiography Study

Cited by 4 publications

References 36 publications

Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients

Impaired retinal oxygen metabolism and perfusion are accompanied by plasma protein and lipid alterations in recovered COVID-19 patients

Obesity, body fat distribution and eye diseases

Retinal microcirculation: A window into systemic circulation and metabolic disease

Contact Info

Product

Resources

About