Retinal microcirculation: A window into systemic circulation and metabolic disease

Yuan, Yue; Dong, Meiyuan; Wen, Song; Yuan, Xinlu; Zhou, Ligang

doi:10.1016/j.exer.2024.109885

Experimental Eye Research

2024

DOI: 10.1016/j.exer.2024.109885

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Retinal microcirculation: A window into systemic circulation and metabolic disease

Yue Yuan,

Meiyuan Dong,

Song Wen

et al.

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2024

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Potential of Sulodexide in the Treatment of Diabetic Retinopathy and Retinal Vein Occlusion

Böhm,

Buonfiglio,

Korb

et al. 2024

Thromb Haemost

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Retinal vascular diseases, such as diabetic retinopathy or retinal vein occlusion, are common causes of severe vision loss. Central to the pathophysiology of these conditions are endothelial dysfunction, inflammation, capillary leakage, ischemia, and pathological neoangiogenesis. Capillary damage leads to leakage and the development of macular edema, which is associated with vision loss and requires complex treatment. Sulodexide, a glycosaminoglycan composed of heparan sulfate and dermatan sulfate with high oral bioavailability, exhibits several favorable pharmacologic properties, including antithrombotic, anti-inflammatory, and endothelium-protective effects. Additionally, treatment with sulodexide has been associated with the reduction of oxidative stress and decreased expression of angiogenic growth factors, such as vascular endothelial growth factor. This review aims to provide an overview of the pharmacological properties, mechanisms of action, and therapeutic effects of sulodexide. Furthermore, its potential for clinical application in venous and diabetic diseases, such as venous thromboembolism, chronic venous insufficiency, peripheral artery disease, or diabetic nephropathy, is summarized. We also present experimental and clinical studies evaluating the potential of sulodexide in ocular conditions and discuss its therapeutic implications for the treatment of retinal vascular diseases.

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Potential of Sulodexide in the Treatment of Diabetic Retinopathy and Retinal Vein Occlusion

Böhm,

Buonfiglio,

Korb

et al. 2024

Thromb Haemost

View full text Add to dashboard Cite

show abstract

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Retinal microcirculation: A window into systemic circulation and metabolic disease

Cited by 1 publication

References 135 publications

Potential of Sulodexide in the Treatment of Diabetic Retinopathy and Retinal Vein Occlusion

Potential of Sulodexide in the Treatment of Diabetic Retinopathy and Retinal Vein Occlusion

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