Association of Body Compositions and Bone Mineral Density in Chinese Children and Adolescents: Compositional Data Analysis

Zhang, Liu; Li, Hongjuan; Zhang, Yimin; Kong, Zhenxing; Zhang, Ting; Zhang, Zhaohua

doi:10.1155/2021/1904343

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…Globally, recognized standards for defining obesity include BMI and WC ( 14 , 25 – 27 ). Numerous studies have reported a positive correlation between BMI, WC, and BMD ( 28 , 29 ). Leonard, et al.…”

Section: Discussionmentioning

confidence: 99%

The association between weight-adjusted-waist index and total bone mineral density in adolescents: NHANES 2011–2018

Wang

Yang

et al. 2023

Front. Endocrinol.

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IntroductionThe weight-adjusted waist index (WWI) serves as an innovative obesity measure, seemingly surpassing body mass index (BMI) and waist circumference (WC) in evaluating lean and fat mass. This study aimed to explore the relationship between WWI and total bone mineral density (BMD) in US adolescents.MethodsThis population-based study investigated adolescents aged 8–19 years with comprehensive WWI and total BMD data from the National Health and Nutrition Examination Survey (NHANES) 2011–2018. WWI was computed by dividing WC by the square root of body weight. Weighted multivariate linear regression and smoothed curve fitting were employed to examine linear and non-linear associations. Threshold effects were determined using a two-part linear regression model. Additionally, subgroup analyses and interaction tests were conducted.ResultsMultivariate linear regression analysis revealed a significant negative association between WWI and total BMD in 6,923 US adolescents aged 8–19 years [β = -0.03, 95% CI: (-0.03, -0.03)]. This negative correlation remained consistent across all subcategories, with the exception of age, encompassing gender,ethnicity, and diabetes status subgroups. Furthermore, a non-linear relationship and saturation effect between WWI and total BMD were identified, with an inflection point at 9.88 cm/√kg.ConclusionsOur research demonstrated a notable negative relationship and saturation effect between WWI and total BMD among US adolescents.

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Section: Discussionmentioning

confidence: 99%

The association between weight-adjusted-waist index and total bone mineral density in adolescents: NHANES 2011–2018

Wang

Yang

et al. 2023

Front. Endocrinol.

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“…Ling Bai reported the results of body composition using the BIA in Chinese children (10–18 years old), mainly focus the attention on the associations of body fat distribution and lean body mass with blood pressure in normal-weight children and adolescents [ 12 ]. Liu Zhang investigated the relationship between body compositions and bone mineral density and the effect of composition substitution among Chinese children (5-18years old) [ 13 ]. However, previous analysises of body composition of children and adolescents have seldom focused on the specific changes in body composition that occurs with age, and comprehensive large samples studies were quite deficient, making it difficult to assess the growth trend and related health risks of children.…”

Section: Introductionmentioning

confidence: 99%

Cross-sectional study of characteristics of body composition of 24,845 children and adolescents aged 3–17 years in Suzhou

Zhao

Gong

et al. 2023

BMC Pediatr

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Background We aimed to analyze the characteristics of the body composition of children and adolescents aged 3–17 in Suzhou, China. Methods A cross-sectional study between January 2020 and June 2022 using bioelectrical impedance was conducted to determine the fat mass (FM), fat-free mass (FFM), skeletal muscle mass, and protein and mineral contents of 24,845 children aged 3–17 who attended the Department of Child and Adolescent Healthcare, Children’s Hospital of Soochow University, China. Measurement data was presented in tables as mean ± SD, and groups were compared using the independent samples t-test. Results FM and fat-free mass increased with age in both boys and girls. The fat-free mass of girls aged 14–15 decreased after reaching a peak, and that of boys in the same age group was higher than that of the girls (p < 0.05). There were no significant differences in FM between boys and girls younger than 9- and 10-years old. The percentage body fat (PBF) and FM index of girls increased rapidly between 11 and 15 years of age (p < 0.05), and those of boys aged 11–14 were significantly lower (p < 0.05), suggesting that the increase in body mass index (BMI) was mainly contributed by muscle mass (MM) in boys. Conclusions The body composition of children and adolescents varies according to their age and sex. A misdiagnosis of obesity made on the basis of BMI alone can be avoided if BMI is used in combination with FM index, percentage body fat, and other indexes.

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Effect of obesity status on adolescent bone mineral density and saturation effect: A cross-sectional study

Wang

Fang²,

Li³

et al. 2022

Front. Endocrinol.

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BackgroundThe effect of obesity status on bone mineral density (BMD) in adolescents and whether there is a saturation effect is still insufficient. A cross-sectional study of adolescents aged 12–19 was conducted to investigate them.MethodsWeighted multivariate linear regression models were used to assess the relationship between obesity status and BMD via datasets from the National Health and Nutrition Examination Survey 2011–2018. The nonlinear relationships and saturation values were ascertained by fitting smooth curves and analyzing saturation effects. At the same time, the subgroup stratified analysis was also performed.Results4056 adolescents were included in this study. We found that body mass index (BMI) and waist circumference (WC) were significantly associated with total BMD, which remained significant in subgroups stratified by age, gender, standing height, and ethnicity. We also noticed an inverse correlation between left leg fat/lean mass and left leg BMD, which was only significant in males and other races. Fitting smooth curve and saturation effect analysis showed that BMI, WC, left leg fat/lean mass, and BMD had a specific saturation effect. There was a saturation effect on bone mineral density in adolescents with a BMI of 22 kg/m2, a WC of 70.5 cm, or a left leg fat/lean mass of 0.2994.ConclusionsWe found a positive saturation effect of BMI and WC with BMD and a negative saturation effect of left leg fat/lean mass with BMD. Appropriate obesity status allows adolescents to have better bone mass development but not excessive obesity.

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Association of Body Compositions and Bone Mineral Density in Chinese Children and Adolescents: Compositional Data Analysis

Cited by 3 publications

References 32 publications

The association between weight-adjusted-waist index and total bone mineral density in adolescents: NHANES 2011–2018

The association between weight-adjusted-waist index and total bone mineral density in adolescents: NHANES 2011–2018

Cross-sectional study of characteristics of body composition of 24,845 children and adolescents aged 3–17 years in Suzhou

Effect of obesity status on adolescent bone mineral density and saturation effect: A cross-sectional study

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