Effect of obesity status on adolescent bone mineral density and saturation effect: A cross-sectional study

Abstract

BackgroundThe effect of obesity status on bone mineral density (BMD) in adolescents and whether there is a saturation effect is still insufficient. A cross-sectional study of adolescents aged 12–19 was conducted to investigate them.MethodsWeighted multivariate linear regression models were used to assess the relationship between obesity status and BMD via datasets from the National Health and Nutrition Examination Survey 2011–2018. The nonlinear relationships and saturation values were ascertained by fitting smooth curves and analyzing saturation effects. At the same time, the subgroup stratified analysis was also performed.Results4056 adolescents were included in this study. We found that body mass index (BMI) and waist circumference (WC) were significantly associated with total BMD, which remained significant in subgroups stratified by age, gender, standing height, and ethnicity. We also noticed an inverse correlation between left leg fat/lean mass and left leg BMD, which was only significant in males and other races. Fitting smooth curve and saturation effect analysis showed that BMI, WC, left leg fat/lean mass, and BMD had a specific saturation effect. There was a saturation effect on bone mineral density in adolescents with a BMI of 22 kg/m2, a WC of 70.5 cm, or a left leg fat/lean mass of 0.2994.ConclusionsWe found a positive saturation effect of BMI and WC with BMD and a negative saturation effect of left leg fat/lean mass with BMD. Appropriate obesity status allows adolescents to have better bone mass development but not excessive obesity.

Prevalence of hyperuricemia and its correlation with metabolic syndrome in young adults: a cross-sectional study in eastern China

“…In addition, our results found MS components were independent risk factors for HUA prevalence, including overweight, hypertension, dyslipidemia. The positive relationship between overweight and the presence of HUA has been documented in previous study and HUA prevalence was reported to reach 66.9% in obese individuals [2,31]. The nding may be directly explained by the fact that increased amount of dietary purine intake in obese subjects.…”

The saturation effect of body mass index on total lumbar bone mineral density for adults: The NHANES 2011–2020

“…[7][8][9][10] In previous studies, body mass index (BMI) has been proven to be closely related to BMD. [11][12][13][14][15] In a cross-sectional study of 4056 adolescents ages 12 to 19, Wang et al found that BMI was significantly associated with total BMD, which remained significant in subgroups stratified by gender, age, ethnicity, and standing height. [12] Li et al evaluated 2218 participants aged 40 to 59 years, and found that BMI was positively related with lumbar BMD in middle-aged adults.…”

“…[11][12][13][14][15] In a cross-sectional study of 4056 adolescents ages 12 to 19, Wang et al found that BMI was significantly associated with total BMD, which remained significant in subgroups stratified by gender, age, ethnicity, and standing height. [12] Li et al evaluated 2218 participants aged 40 to 59 years, and found that BMI was positively related with lumbar BMD in middle-aged adults. [13] Another study based on 3296 participants aged 50 years and older confirmed a positive correlation between BMI and BMD in older adults.…”

“…[11] In a cross-sectional study of 4056 adolescents, Wang et al indicated a positive saturation effect between BMI and BMD. [12] To our knowledge, there are few studies on the relationship between BMI and BMD in adults. In the present study, we conducted a cross-sectional analysis based on the National Health and Nutrition Examination Survey (NHANES) database.…”

“…[7][8][9][10] In previous studies, body mass index (BMI) has been proven to be closely related to BMD. [11][12][13][14][15] A study in a total of 10,910 participants over 50 years showed that BMI was positively related with BMD, and demonstrated keeping the BMI at a slightly overweight value (26 kg/m 2 ) would obtain an optimal balance between BMI and BMD for people over 50 years old. [11] In a cross-sectional study of 4056 adolescents, Wang et al indicated a positive saturation effect between BMI and BMD.…”