Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study

Oh, Hyung Jung; Lee, Seulbi; Lee, Eun Kyung; Lee, Oesook; Ha, Eun–Hee; Park, Eun Mi; Kim, Seung Jung; Kang, Duk Hee; Choi, Kyu Bok; Kim, Seung Jun; Ryu, Dong Ryeol

doi:10.1080/07853890.2018.1492146

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…Blood pressure control, especially high systolic blood pressure and low diastolic blood pressure, is related to the clinical cardiovascular and cerebrovascular outcome. [ 27 – 32 ] Owing to the limitations of real-world blood pressure information, we could not offer the BP management result that may be needed after full consideration of age and sex which can significantly influence health behaviors. Second, the LHID 2010 and 2005 did not include personal risk factors for hypertension, including smoking, body mass index, exercise, salt intake, and drinking.…”

Section: Discussionmentioning

confidence: 99%

“…Future directions of the study should include the blood pressure data of the patients because the treatment rate and blood pressure level are related to the cardiovascular events. [ 9 , 27 – 32 ] The third limitation is we did not have LHID datasets earlier than 2005 or later than 2010 and these have helped in understanding these trends. This also aims our consideration for future study to collect more variables about the clinical patient data, including BMI, waist circumference, metabolic syndrome, lipids, exercise, smokers, liver steatosis, alcohol intake, lung disease¸ gout, atrial fibrillation, high-sensitivity C-reactive protein, Fasting glucose, depression, valve disorder, complete blood tests, family history of stroke, CAD, peripheral arterial disease, and stroke subtypes which may significantly affect clinical decisions.…”

Section: Discussionmentioning

confidence: 99%

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Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010

Liao

Shih

et al. 2020

Medicine

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Hypertension continues to be an important public health concern because of its associated morbidity, mortality, and economic impact on society. The aims of this study are to compare the secular changes in age-stratified hypertension prevalence, incidence, co-morbidity, and 3 years of cardiovascular outcome in Taiwan in the years 2005 and 2010. We enrolled hypertensive individuals from the datasets of the Longitudinal Health Insurance Database (LHID) in 2005 and 2010 in Taiwan separately. We analyzed the hypertension prevalence, incidence, medication treatment, and associated morbidities. The risks of cardiovascular and cerebrovascular events and all-causes mortalities among the hypertensive individuals were evaluated in 3 years of follow-up. There was an increased prevalence of hypertension but decreased incidence of hypertension in those over 65 from 2005 to 2010. Dyslipidemia was the highest rate of co-morbidity in 2005 and 2010. The most frequent categories of anti-hypertensive agents prescribed was 1 or 2 for both 2005 and 2010. Calcium channel blockers were the most common anti-hypertensive agents prescribed, followed by Angiotensin converting enzyme inhibitors/Angiotensin receptor blockers. After 3 years of follow-up, the risks of coronary artery disease (CAD), cerebrovascular diseases (CVD) as well as death were less in 2010 than in 2005 in Taiwan. Our study showed that hypertension individuals had an increased prevalence, younger age, decreased incidence, increased medication treatment associated with decreased the CAD, CVD, and mortalities in 2010 compared to 2005 in Taiwan.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010

Liao

Shih

et al. 2020

Medicine

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“…Additionally, hospitalization was defined as admission to a hospital for at least consecutive 2 days. The occurrence of MACE was monitored for 10 years from January 1, 2004 to December 31, 2013 14 .…”

Section: Methodsmentioning

confidence: 99%

Age and sex specific target of blood pressure for the prevention of cardiovascular event among the treatment naive hypertensive patients

Kim

Lee

et al. 2020

Sci Rep

Self Cite

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The time at which hypertension treatment should be initiated for different age groups and sexes remains controversial. We aimed to determine whether the association between blood pressure (BP) and major adverse cardiovascular events (MACE) varies with age and sex. This study enrolled 327,328 subjects who had not taken antihypertensive medication in the Korean National Health Service-National Health Screening Cohort between 2002 and 2003. Participants were categorized into four groups according to 2017 American College of Cardiology/American Heart Association hypertension guideline. Primary outcome was MACE characterized by cardiovascular mortality, myocardial infarction, unstable angina, and stroke. During a 10-year follow-up, a significant increase in MACE risk was observed from the stage 1 hypertension group (hazard ratio [HR], 1.23; 95% CI 1.15–1.32; P < 0.001) in time-varying Cox analysis. This relationship was persistent in subjects aged < 70 years, but increased MACE risk was observed only in the stage 2 hypertension group in ≥ 70 years (HR, 1.52; 95% CI 1.32–1.76, P < 0.001). When categorized as per sex, both men and women showed significant MACE risk from stage 1 hypertension. However, on comparing the sexes after stratifying by age, a significantly increased risk of MACE was shown from stage 1 hypertension in men aged < 50 years, but from stage 2 hypertension in men aged ≥ 50 years. Meanwhile, increased MACE risk was observed from stage 2 hypertension in women aged < 60 years, but from stage 1 hypertension in women aged ≥ 60 years. Thus, young male subjects had higher MACE risk than young female subjects, but this difference gradually decreased with age and there was no difference between sexes in subjects aged ≥ 70 years. Therefore, our results suggest that hypertension treatment initiation may need to be individualized depending on age and sex.

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“…Since systolic blood pressure tends to increase and diastolic blood pressure tends to decrease with increasing age, the difference between systolic and diastolic blood pressure, pulse pressure, adds an additional indicator to be examined in relating blood pressures and mortality at older ages. A widened pulse pressure may mean lower diastolic blood pressure or higher systolic blood pressure or both, all of them indicating arterial stiffness, atherosclerosis, or increased arterial stiffness [12].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have examined the relative importance of systolic, diastolic and pulse pressure on mortality [12][13][14][15][16][17][18]. Pastor-Barriuso et al examined the joint effect of systolic and diastolic blood pressure on mortality by examining how increasing systolic blood pressure for a fixed diastolic blood pressure and how increasing diastolic blood pressure for a fixed systolic blood pressure are related to relative risk of mortality [16].…”

Section: Introductionmentioning

confidence: 99%

Blood Pressure and Mortality: Joint Effect of Blood Pressure Measures

Kim

Crimmins

2020

J. clin. cardiol. cardiovasc. ther.

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Association of blood pressure components with mortality and cardiovascular events in prehypertensive individuals: a nationwide population-based cohort study

Cited by 13 publications

References 31 publications

Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010

Higher hypertension prevalence, lower incidence, and aggressive treatment with decreasing mortality, cardiovascular, and cerebrovascular incidence in Taiwan from 2005 to 2010

Age and sex specific target of blood pressure for the prevention of cardiovascular event among the treatment naive hypertensive patients

Blood Pressure and Mortality: Joint Effect of Blood Pressure Measures

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