Association of bacterial infection and red blood cell transfusion after coronary artery bypass surgery

Allogeneic leukocytes in cardiac surgery: Good or bad?

“…Several observational studies on cardiac surgery reported that perioperative administration of blood products is dose-dependently associated with increases in the incidence of postoperative infections and mortality [27]. Observational studies observed that RBC transfusion was the most consistent factor associated with mortality and morbidity [28,29]; however, these were retrospective studies and therefore provide no proof of the causal effect of allogeneic RBC transfusion on postoperative morbidity and mortality after cardiac surgery, in which many factors influence outcome; to date, this association is not fully understand.…”

Transfusion of autologous blood

“…Deja, alogeninio kraujo perpylimas susijęs su daugeliu problemų: kraujo, kaip biologinio audinio, išteklių ribotumu, augančiais kraujo paruošimo kaštais, krauju perduodamų infekcinių ligų pavojumi, neigiamu imunomoduliaciniu poveikiu recipientui, pneumonija bei kitomis pooperacinėmis infekcijomis, piktybinių navikų išplitimo bei jų atsinaujinimo rizika (2)(3)(4)(5)(6)(7)(8)(9). Yra duomenų, kad alogeninio kraujo perpylimas didina sergamumą, mirtingumą, ilgina lovadienių trukmę intensyviosios terapijos skyriuose gydomiems ligoniams (8).…”

Immunomodulatory Effects of Stored Packed Red Blood Cells in the Injured Patient

“…[17][18][19][20][21][22][23][24][25] These studies not only include patients who underwent resections of colorectal cancer, surgery for any disease of the colon, rectum, or gastrointestinal tract, but also detail patients requiring elective intervention for orthopedic and gynecologic problems as well as cardiovascular disease. [17][18][19][20][21][22][23][24][25] By and large, these studies did not investigate the dose of components; however, three studies demonstrated increasing infections with the amount of packed red blood cells (PRBCs) administered in patients requiring cardiovascular bypass or colorectal surgery. 17,18,20 In addition, van de Watering and colleagues studied patients who required coronary artery bypass, coronary valve replacement or a combination of both, and demonstrated increased rates of transfusion-related postoperative bacterial infection, although these investigators did not look at transfusion dosage or types of components either singly or in combination that linked patients to postoperative infections.…”

“…[17][18][19][20][21][22][23][24][25] By and large, these studies did not investigate the dose of components; however, three studies demonstrated increasing infections with the amount of packed red blood cells (PRBCs) administered in patients requiring cardiovascular bypass or colorectal surgery. 17,18,20 In addition, van de Watering and colleagues studied patients who required coronary artery bypass, coronary valve replacement or a combination of both, and demonstrated increased rates of transfusion-related postoperative bacterial infection, although these investigators did not look at transfusion dosage or types of components either singly or in combination that linked patients to postoperative infections. 12 With respect to injured patients who require immediate surgical intervention, seven observational studies, three with control groups, demonstrated a correlation between transfusion and/or transfusion "dose" and a higher incidence of postoperative infection (Table 1).…”