Transfusion of autologous blood

Veikutienė, Audronė; Širvinskas, Edmundas; Adukauskienė, Dalia

doi:10.3390/medicina44060063

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…Autologous blood transfusion (ABT) is the collection and reinfusion or transfusion of one's own blood or blood components before, during or after surgical procedures and may be another promising direction in lncRNA-based therapy 121 . Clinical treatment with ABT can prevent further damage to red blood cell function in diabetic patients and thus improve the function of fibroblasts function, which play a role in wound healing 122 .…”

Section: Progress and Prospects Of Lncrnas In Diagnosis And Treatmentmentioning

confidence: 99%

LncRNAs associated with oxidative stress in diabetic wound healing: Regulatory mechanisms and application prospects

Yang¹,

Fang²,

Chen³

et al. 2023

Theranostics

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Diabetes is a group of chronic diseases with blood glucose imbalance, and long-term hyperglycaemia causes sustained damage to various organs of the body, resulting in vascular lesions, neuropathy and impaired wound healing. Diabetic wound formation involves a variety of complex mechanisms, and they are characterized by a persistent chronic inflammatory response, degradation of angiogenesis and imbalance of extracellular matrix regulation, all of which are related to oxidative stress. Additionally, repair and healing of diabetic wounds require the participation of a variety of cells, cytokines, genes, and other factors, which together constitute a complex biological regulatory network. Recent studies have shown that long noncoding RNAs (lncRNAs) can be involved in the regulation of several key biological pathways and cellular functions demonstrating their critical role in diabetic wound healing. LncRNAs are a major family of RNAs with limited or no protein-coding function. Numerous studies have recently reported a strong link between oxidative stress and lncRNAs. Given that both lncRNAs and oxidative stress have been identified as potential drivers of diabetic wound healing, their link in diabetic wound healing can be inferred. However, the specific mechanism of oxidative stress related to lncRNAs in diabetic wound healing is still unclear, and elucidating the functions of lncRNAs in these processes remains a major challenge. This article reviews the mechanisms of lncRNAs related to oxidative stress in several stages of diabetic wound healing and discusses diagnostic and treatment potential of lncRNAs to treat diabetic wounds by improving oxidative stress, as well as the challenges of using lncRNAs for this purpose. It is hoped that these results will provide new targets and strategies for the diagnosis and treatment of impaired wound healing in diabetic patients.

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Section: Progress and Prospects Of Lncrnas In Diagnosis And Treatmentmentioning

confidence: 99%

LncRNAs associated with oxidative stress in diabetic wound healing: Regulatory mechanisms and application prospects

Yang¹,

Fang²,

Chen³

et al. 2023

Theranostics

View full text Add to dashboard Cite

show abstract

“…This list includes “autologous blood transfusion (ABT)” in “M1. MANIPULATION OF BLOOD AND BLOOD COMPONENTS.” ABT is a collection of blood from a single patient and retransfusion back to the same patient when a large amount of bleeding is expected due to surgery that is highly invasive, such as orthopedic, cardiovascular, or cerebrovascular surgery [ 5 , 6 , 7 , 8 ]. This is in contrast to allogenic blood transfusion, where blood from unrelated/anonymous donors is transfused to the recipient, which has many advantages for patients in need of transfusions.…”

Section: Introductionmentioning

confidence: 99%

Identification of RNA Markers in Red Blood Cells for Doping Control in Autologous Blood Transfusion

Sugasawa

Kanki

Komine

et al. 2022

Genes

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The World Anti-Doping Agency (WADA) has prohibited the use of autologous blood transfusion (ABT) as a doping method by athletes. It is difficult to detect this doping method in laboratory tests, and a robust testing method has not yet been established. We conducted an animal experiment and used total RNA sequencing (RNA-Seq) to identify novel RNA markers to detect ABT doping within red blood cells (RBCs) as a pilot study before human trials. This study used whole blood samples from Wistar rats. The whole blood samples were mixed with a citrate–phosphate–dextrose solution with adenine (CPDA) and then stored in a refrigerator at 4 °C for 0 (control), 10, or 20 days. After each storage period, total RNA-Seq and bioinformatics were performed following RNA extraction and the purification of the RBCs. In the results, clear patterns of expression fluctuations were observed depending on the storage period, and it was found that there were large numbers of genes whose expression decreased in the 10- and 20-day periods compared to the control. Moreover, additional bioinformatic analysis identified three significant genes whose expression levels were drastically decreased according to the storage period. These results provide novel insights that may allow future studies to develop a testing method for ABT doping.

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Autologous Blood Transfusion During Elective Surgery in a Candidate for Living Donor Transplantation: A Case Report

Jankowska,

Akily,

Karlsen

et al. 2024

Transplantation Proceedings

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Transfusion of autologous blood

Cited by 4 publications

References 29 publications

LncRNAs associated with oxidative stress in diabetic wound healing: Regulatory mechanisms and application prospects

LncRNAs associated with oxidative stress in diabetic wound healing: Regulatory mechanisms and application prospects

Identification of RNA Markers in Red Blood Cells for Doping Control in Autologous Blood Transfusion

Autologous Blood Transfusion During Elective Surgery in a Candidate for Living Donor Transplantation: A Case Report

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