Association of Atopic Dermatitis and Mental Health Outcomes Across Childhood

Abstract

highlighted associations between atopic dermatitis (AD) and mental health conditions in adults. However, literature on the development of mental health comorbidities in children is limited despite the large burden of pediatric AD worldwide.OBJECTIVE To examine the association between AD and internalizing behaviors and symptoms of depression at multiple points across childhood and adolescence and to explore potential mediating factors, including asthma/rhinitis, sleep, and inflammation. DESIGN, SETTING, AND PARTICIPANTSThis longitudinal, population-based birth cohort study included children followed up from birth for a mean (SD) duration of 10.0 (2.9) years from the

Acupuncture attenuates comorbid anxiety- and depressive-like behaviors of atopic dermatitis through modulating neuroadaptation in the brain reward circuit in mice

“…Emerging evidence indicates that people with AD suffer from psychological stress, which can markedly increase the prevalence of anxiety and depression and in turn aggravate AD symptoms [ 3 , 4 , 32 ]. AD mice with anxiety- and depression-like symptoms were also in a heightened state of stress, as indicated by elevated basal corticosterone levels.…”

“…Over the past several years, evidence has shown an association between AD and psychological comorbidities such as anxiety and depression [ 3 , 4 ], which can lead to reduced health status, health-related quality of life, and work productivity [ 5 , 6 ]. Although anxiety and depression symptoms are particularly associated with more severe AD [ 7 ], even mild AD may be accompanied by these emotional states [ 8 ].…”

Atopic dermatitisReview of comorbidities and therapeutics

“…Those with active AD had increased odds of exhibiting internalizing behaviors (adjusted OR, 1.41; 95% CI, 1.17-1.70) and increasing AD severity had a dose-dependent effect on odds of such behaviors. 18 Adults with AD carried almost double the odds of depression (OR, 1.99; 95% CI, 1.53-2.59), 40% increased odds of anxiety (OR, 1.40; 95% CI, 1.12-1.75), and 71% increased odds of suicidal ideation (OR, 1.71; 95% CI, 1.43-2.03) compared with nonaffected counterparts. 5 The National Survey of Children's Health found significant associations between pediatric AD and autism, conduct disorders, attention deficit hyperactivity disorder, and depression and anxiety, with odds ratios of 3.04 (95% CI 2.…”

What are patients saying about their experience with atopic dermatitis? Insights from a machine learning analysis of online comments

“… 4 A cohort study detected odds ratios for depression of 1.29–1.84 for mild‐moderate AD and 2.38 for severe AD. 5 Findings of internalising behaviour were also more frequent in patients with AD, especially if their disease had an early age of onset. 5 Additional publications linked AD to risk of suicide, stress, and overall dissatisfaction with life in both patients and caregivers.…”

“… 5 Findings of internalising behaviour were also more frequent in patients with AD, especially if their disease had an early age of onset. 5 Additional publications linked AD to risk of suicide, stress, and overall dissatisfaction with life in both patients and caregivers. 6 , 7 Many medical conditions may unmask or exacerbate behavioural health conditions.…”