Association of apolipoprotein A1 with osteoporosis: a cross-sectional study

Abstract

Summary Higher levels of apolipoprotein A1 (ApoA1) were associated with higher risk of osteoporosis, which supports the argument that lipid metabolism is involved in bone metabolism. Background Although the current evidence shows that lipid metabolism and osteoporosis are closely related to cardiovascular disease, the association between ApoA1 and osteoporosis is still unknown. Therefore, the purpose of this study was to explore the relationship between ApoA1 and osteoporosis. Methods In this cross-sectional study, we included 7743 participants in the Third National Health and Nutrition Examination Survey. ApoA1 was regarded as an exposure variable and osteoporosis was considered as an outcome variable. Multivariate logistic regression analysis, sensitivity analysis, and receiver operator characteristic (ROC) were used to assess the association of ApoA1 with osteoporosis. Results Participants with higher ApoA1 had higher rates of osteoporosis compared to participants with lower ApoA1 (P < 0.05). Individuals with osteoporosis had higher levels of ApoA1 than individuals without osteoporosis (P < 0.05). In multivariate logistic regression analysis adjusted for age, sex, race, hypertension, diabetes, gout, hypotensive drugs, hypoglycemic drugs, systolic blood pressure, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, apolipoprotein B, blood urea nitrogen, albumin, uric acid, hemoglobin A1c, alkaline phosphatase and total calcium, higher ApoA1 was strongly associated with higher risk of osteoporosis, whether as a continuous variable or a categorical variable [Model 3, OR (95% CI), P value: 2.289 (1.350, 3.881), 0.002 and 1.712 (1.183, 2.478), 0.004]. And after excluding individuals with gout, the correlation between them remained and was significant (P < 0.01). And ROC analysis also showed that ApoA1 could predict the development of osteoporosis (AUC = 0.650, P < 0.001). Conclusion ApoA1 was closely associated with osteoporosis.

Association between hypertension and osteoporosis: a population-based cross-sectional study

“…Moreover, another cross-sectional study also found that higher triglyceride and total cholesterol levels were associated with a greater prevalence of osteoporosis [ 26 ]. It was also shown that participants with higher apolipoprotein A1 levels had a 71.2% greater risk of developing osteoporosis than those with lower apolipoprotein A1 levels, and for each one-unit increase in apolipoprotein A1, the risk was 1.29 times greater [ 27 ]. Moreover, two previous studies demonstrated that the renin-angiotensin system (RAS) plays a significant role in osteoporosis, where the activation of the local RAS in bone tissue can lead to increased bone resorption, thereby triggering osteoporosis, and the use of RAS inhibitors can significantly reduce the incidence of osteoporosis and osteoporotic fractures [ 28 , 29 ].…”

Associations between apolipoprotein B and bone mineral density: a population-based study

“…Lipids play a vital role in various physiological processes, including bone metabolism. Several studies have underscored the influence of lipids on bone health [ 5 ], indicating a potential association between specific lipid components, such as apolipoprotein B (apo B), and BMD [ 6 ]. Apo B, a primary component of atherogenic lipoproteins with two major isoforms: apo B48 and apo B100 [ 7 ], is implicated in numerous metabolic processes besides cholesterol transport.…”