Association of aortic stiffness, carotid intima-media thickness and endothelial function with cardiovascular events in metabolic syndrome subjects

Ryliškytė, Ligita; Navickas, Rokas; Šerpytis, Pranas; Puronaitė, Roma; Zupkauskienė, Jūratė; Jucevičienė, Agnė; Badarienė, Jolita; Rimkienė, Mantė Agnė; Ryliškienė, Kristina; Skiauteryte, E.; Laucevičius, Aleksandras

doi:10.1080/08037051.2019.1569461

Cited by 15 publications

(16 citation statements)

References 28 publications

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“…14 In metabolic syndrome patients, each one stándar deviation worsening in endothelial function measured by FMD was associated with doubled cardiovascular risk. 15 Microvascular endotelial dysfunction, measured by peripheral arterial tonometry, was associated with two-fold increased risk of developing solid-tumor cancer. 16 Metabolic syndrome, wich is associated to endothelial dysfunction, also increase the incidence of cancer.…”

Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in metabolic syndrome patients with and without hypertension

Garcia¹,

Bermúdez²,

Manfredi³

et al. 2020

JCCR

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The objective is to investigate if patients with metabolic syndrome have a difference in endothelial function (EF) and functional aerobic capacity as they were normotensive or hypertensive. Sixty-three consecutive primary prevention patients who came for the first time to a metabolic clinic, were studied with stress test and flow mediated dilation (FMD). The study was blind for the crossover results. Mean population age was 52 years and 60% among them were men. Ninety percent of patients accomplished metabolic syndrome criteria (by International Diabetes Federation criteria). There was no a significant difference in functional aerobic capacity between normotensive and hypertensive patients, despite it was calculated by METS achieved in the stress test (median 5.81 and 4.63 p=0.114) or by percent of capacity predicted by gender and age (median 79.7% and 63.2% p=0.243).In the whole population we found a significant difference in EF between normotensive and hypertensive (median 10% and 8% p=0.002) and between patients without and with metabolic syndrome (median 11% and 8% p=0.023). In the group of patients with metabolic syndrome we found also a significant difference in EF between normotensive and hypertensive (median 10% and 7.5% p=0.006) but we did not find a significant difference in functional aerobic capacity. Endothelial function was associated to hypertension and waist in multiple linear regression model. We conclude that in this population patients with metabolic syndrome and hypertension have poorer endothelial function than patients with metabolic syndrome and normotension.

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Section: Discussionmentioning

confidence: 99%

Endothelial dysfunction in metabolic syndrome patients with and without hypertension

Garcia¹,

Bermúdez²,

Manfredi³

et al. 2020

JCCR

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“…1 , Малютина С. К. 1,2 Эндотелиальная дисфункция (ЭД), толщина интимо-медиального комплекса (ТИМК) и атеросклеротические бляшки (АСБ) сонных артерий (СА) считаются взаимно ассоциированными маркерами субклинического и явного атеросклероза. Насколько верно данное утверждение для старших возрастных групп, остается неясным.…”

Section: эндотелиальная функция и структурные маркеры атеросклероза: ...unclassified

“…Неинвазивным способом оценки ЭД является тест измерения поток-зависимой вазодилатации (ПЗВД) -суррогатного маркера вазодилатационного резерва артерий. Снижение функционального показателя ПЗВД предсказывает возникновение сердечно-сосудистых событий [2], а нормальное значение ПЗВД ассоциируется со сниженным риском развития атеросклероза и его осложнений. Толщина комплекса "интима-медия" (ТИМК) и атеросклеротические бляшки (АСБ) сонных артерий (СА) отражают морфологический компонент сосудистых изменений, а утолщение ТИМК и АСБ являются независимым предиктором повышенного кардиоваскулярного риска [3].…”

Section: Relationships and Activitiesunclassified

Endothelial function and structural markers of atherosclerosis: relationship in old and senile age

et al. 2021

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Endothelial dysfunction (ED), intima-media thickness (IMT), and atherosclerotic plaques (ASPs) of the carotid arteries (CAs) are considered mutually associated markers of subclinical and clinical atherosclerosis. How true this statement is for older age groups remains unclear.Aim. To study the relationship of flow-dependent vasodilation (FDV) with CA IMT and ASPs in a population sample over 58 years old.Material and methods. The study was carried out in a population sample of men and women aged 58-82 years (Novosibirsk, HAPIEE project, n=788, 424 women). CA ultrasound was performed to assess IMT and ASPs. Endothelial function was assessed by postocclusive hyperemia ultrasound test; an increase in brachial artery initial diameter (FDV%) <10% was regarded as ED.Results. The average IMT in men was 0,95 mm (SD 0,18) and was significantly higher than in women: 0,88 mm (SD 0,17), p<0,001. The average FDV% values in men were 2,7% (SD 7,32), while in women — 3,2% (SD 7,19) and did not differ significantly by sex. The incidence of ED was 88,2% in men and 85,8% in women. There was no a significant linear relationship between FDV and IMT neither in men (β=-1,76, SD 2,25, p=0,436), nor in women (β=-2,19, SD 2,15, p=0,309). Also, there were no differences in average IMT and ASP frequency in the groups with and without ED among men and women. When divided into age groups, ED was associated with an increase in IMT only in women aged <78 versus women without ED (p=0,047).Conclusion. In the population sample of 58-82 years old, mutual associations of subclinical markers of atherosclerosis (ED, IMT, ASP of CAs) have not been confirmed. Only in women aged <78 years, ED was associated with an increase in IMT. The results obtained indicate that the treatment approaches proposed for young and middle-aged people may be less effective in old and senile age.

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“…In diabetics, the relative risk (RR) for various CVD events is typically increased 2-fold in men and 3-fold in women when compared to middle-aged people without diabetes. The impact of metabolic syndrome on the risk of cardiovascular disease (CVD), coronary heart disease (CHD), type 2 diabetes (T2DM), and changing prevalence in a single population sample in the 1990s have not been thoroughly explored [7][8][9] .…”

Section: Introductionmentioning

confidence: 99%

Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes

Dahilkar

Sardar

Ghosh

2022

ijhs

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Background: The incidence of cardiovascular disease (CVD), coronary heart disease (CHD), and type 2 diabetes mellitus (T2DM) in people with the metabolic syndrome has not been thoroughly established (at least 3 of the following: abdominal adiposity, low HDL cholesterol, high triglycerides, hypertension, and impaired fasting glucose). The goal was to look at the relationship between metabolic syndrome traits and the risk of CVD, CHD, and T2DM. Methods and Results: Over the course of two years, the researchers followed a group of 300 middle-aged persons for the development of new CVD, CHD, and T2DM. Out of 300 subjects, who did not have CVD or T2DM at either visit, the prevalence of the metabolic syndrome (≥3 of 5 traits) was 25.67% (n=77). During follow-up, there were 8 cases of total CHD, 13 cases of CVD and 18 cases of T2DM. Waist girth, BMI, systolic and diastolic BP was significantly (p<0.05) higher in subjects with metabolic syndrome as compared to subjects without metabolic syndrome. Abnormal cholesterol profile was found more in subjects with metabolic syndrome as compared to subjects without metabolic syndrome.

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Association of aortic stiffness, carotid intima-media thickness and endothelial function with cardiovascular events in metabolic syndrome subjects

Cited by 15 publications

References 28 publications

Endothelial dysfunction in metabolic syndrome patients with and without hypertension

Endothelial dysfunction in metabolic syndrome patients with and without hypertension

Endothelial function and structural markers of atherosclerosis: relationship in old and senile age

Metabolic syndrome as a predictor of cardiovascular diseases and type 2 diabetes

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