Association of anti-oxidative capacity of HDL with subclinical atherosclerosis in subjects with and without non-alcoholic fatty liver disease

Karami, Sara; Sarmadi, Negar; Radmard, Amir Reza; Yari, Fatemeh; Pakdel, Abbas; Shabani, Parisa

doi:10.1186/s13098-021-00741-5

Cited by 17 publications

(18 citation statements)

References 38 publications

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“…20 Karami et al found that HDL anti-oxidative functionality might contribute to NAFLD pathogenesis. 21 A new indicator has recently been proposed by Ko et al, namely triglyceride glucose-body mass index (TYG-BMI). Noticeably, TYG-BMI was universally regarded as a more effective predictor of IR (Insulin resistance).…”

Section: Introductionmentioning

confidence: 99%

Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study

Xing¹,

Chen²,

Liu³

et al. 2022

DMSO

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To explore the association between γ-glutamyl transpeptidase to high-density lipoprotein ratio (GGT/HDL), triglyceride glucose-body mass index (TYG-BMI), and metabolic associated fatty liver disease (MAFLD) in a Chinese population with type 2 diabetes (T2DM) by cross-sectional analysis. To investigate the role of GGT/HDL played in MAFLD by TYG-BMI. Patients and Methods: A total of 1434 adult patients hospitalized with T2DM at Hebei General Hospital (Shijiazhuang, China) were included in the study. Patients' demographic and clinical data were collected. Spearman correlation was used to test for an association between GGT/HDL or TYG-BMI and related risk factors of MAFLD among T2DM patients. Multiple logistic regression analyses were performed to investigate the association between GGT/HDL or TYG-BMI and MAFLD. Mediation analysis was used to explore whether TYG-BMI mediated the association between GGT/HDL and MAFLD. Results: A total of 1434 T2DM patients were enrolled, the MAFLD group showed a higher level of GGT/HDL compared to the non-MAFLD group. There was a progressive increase in the prevalence of MAFLD with increasing tertiles of GGT/HDL. After adjusting for confounding factors, multivariate logistic regression analysis revealed that high levels of GGT/HDL were independent risk factors for MAFLD in T2DM patients. BMI further grouped the patients: ≤ 23kg/m2,>23kg/m2. GGT/HDL was found to be an independent risk factor for MAFLD but only in T2DM patients with a BMI greater than 23 kg/m2. Mediation analysis indicated that GGT/HDL had a significant direct effect on MAFLD. Conclusion: GGT/HDL was positively associated with MAFLD incidence in T2DM patients with a BMI greater than 23 Kg/m2, and TYG-BMI partly mediated the association.

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Section: Introductionmentioning

confidence: 99%

Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study

Xing¹,

Chen²,

Liu³

et al. 2022

DMSO

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“…Some regard NAFLD as a hepatic manifestation of METS ( 16 ). Additionally, in previous reports, reduced HDL-c efflux capability and anti-oxidative activity may contribute to the pathophysiology of NAFLD ( 17 ). Given the correlation between GGT and HDL-c and NAFLD, it is vital to investigate the association between the GGT/HDL-c ratio and NAFLD.…”

Section: Introductionmentioning

confidence: 82%

“…In addition, oxidative stress plays a fundamental role in the initiation and progression of NAFLD ( 50 ). Thus, HDL-c anti-oxidative activity might contribute to NAFLD pathogenesis ( 17 ). With high GGT/HDL-c ratios, high GGT with low HDL-c levels may be related to NAFLD.…”

Section: Discussionmentioning

confidence: 99%

Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio has a non-linear association with non-alcoholic fatty liver disease: A secondary prospective cohort study in non-obese Chinese adults

Han

Zhuge

2022

Front. Med.

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ObjectiveThe evidence for a relationship between the ratio of gamma-glutamyl transferase (GGT) to high-density lipoprotein cholesterol (HDL-c) and non-alcoholic fatty liver disease (NAFLD) is currently inadequate. This study aimed to investigate the relationship between the GGT/HDL-c ratio and NAFLD.Materials and methodsThis study is a prospective cohort study that recruited a total of 11,891 non-obese volunteers in a Chinese hospital from January 2010 to December 2014 in a non-selective manner. The Cox proportional-hazards regression model was then used to investigate the relationship between baseline GGT/HDL-c ratio and the probability of developing NAFLD. The non-linear link between the GGT/HDL-c ratio and NAFLD was identified using a Cox proportional hazards regression with cubic spline functions and smooth curve fitting (cubic spline smoothing). Furthermore, we conducted several sensitivity and subgroup analyses. Data had been uploaded to the DATADRYAD website.ResultsThe mean age of study participants was 43.29 ± 14.95 years old, and 6,502 (54.68%) were male. The median (interquartile ranges) of GGT/HDL-c ratio was 15.56 (10.73–23.84). During a median follow-up of 29.35 months, 2028 (17.05%) participants were diagnosed with NAFLD. After adjusting for covariates, the results showed that GGT/HDL-c ratio was positively associated with incident NAFLD (HR = 1.014, 95% CI 1.011–1.017). There was also a non-linear relationship between GGT/HDL-c ratio and NAFLD, and the inflection point of the GGT/HDL-c ratio was 20.35. The effect sizes (HR) on the left and right sides of the inflection point were 1.113 (95% CI 1.096, 1.130) and 1.003 (95% CI 1.000–1.007), respectively. Moreover, the sensitivity analysis demonstrated the robustness of our results. Subgroup analysis showed that GGT/HDL-c ratio was more strongly associated with incident NAFLD in triglyceride (TG) < 1.7 mmol/L participants. In contrast, the weaker association was probed in those with TG ≥ 1.7 mmol/L.ConclusionThe present study reveals a positive and non-linear relationship between the GGT/HDL-c ratio and NAFLD risk in a non-obese Chinese population. GGT/HDL-c ratio is strongly associated with NAFLD when GGT/HDL-c ratio is less than 20.35. Therefore, maintaining the GGT/HDL-c ratio lower than the inflection point is recommended from a treatment perspective.

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“…In a clinical setting, it is widely accepted that antioxidant effects are mostly related to age-related diseases [ 65 ], such as cardiovascular disease [ 66 , 67 ], non-alcoholic fatty liver disease [ 67 ], vascular dementia [ 68 ], Graves’ ophthalmopathy [ 69 ], cancer [ 70 , 71 ], diabetes [ 72 ], etc. ROS, including hydrogen peroxide (H 2 O 2 ), hydroxyl radical (•OH), singlet oxygen (1O 2 ), superoxide (O 2 2− ), etc., is a group of unstable molecules produced by various cells in the human body.…”

Section: Research Progress On Pharmacological Activitymentioning

confidence: 99%

The Chemical and Pharmacological Research Progress on a Kind of Chinese Herbal Medicine, Fructus Malvae

Wang

Zhao

et al. 2022

Molecules

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Since the outbreak of the COVID-19 pandemic, traditional Chinese medicine has played an important role in the treatment process. Furthermore, the discovery of artemisinin in Artemisia annua has reduced the incidence of malaria all over the world. Therefore, it is becoming urgent and important to establish a novel method of conducting systematic research on Chinese herbal medicine, improving the medicinal utilization value of traditional Chinese medicine and bringing great benefits to human health all over the world. Fructus Malvae, a kind of Chinese herbal medicine which has been recorded in the “Chinese Pharmacopoeia” (2020 edition), refers to the dry, ripe fruits of Malva verticillata L. Recently, some studies have shown that Fructus Malvae exhibits some special pharmacological activities; for example, it has diuretic, anti-diabetes, antioxidant and anti-tumor properties, and it alleviates hair loss. Furthermore, according to the reports, the active ingredients separated and identified from Fructus Malvae contain some very novel compounds such as nortangeretin-8-O-β-d-glucuronopyranoside and 1-O-(6-deoxy-6-sulfo)-glucopyranosyl-2-O-linolenoyl-3-O-palmitoyl glyceride, which could be screened as important candidate compounds for diabetes- or tumor-treatment drugs, respectively. Therefore, in this research, we take Fructus Malvae as an example and systematically summarize the chemical constituents and pharmacological activity research progress of it. This review will be helpful in promoting the development and application of Fructus Malvae and will also provide an example for other investigations of traditional Chinese medicine.

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Association of anti-oxidative capacity of HDL with subclinical atherosclerosis in subjects with and without non-alcoholic fatty liver disease

Cited by 17 publications

References 38 publications

Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study

Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study

Gamma-glutamyl transferase to high-density lipoprotein cholesterol ratio has a non-linear association with non-alcoholic fatty liver disease: A secondary prospective cohort study in non-obese Chinese adults

The Chemical and Pharmacological Research Progress on a Kind of Chinese Herbal Medicine, Fructus Malvae

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