Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study

Xing, Yingbin; Chen, Jinhu; Liu, Jing; Ma, Huijuan

doi:10.2147/dmso.s342505

Cited by 27 publications

(25 citation statements)

References 60 publications

(57 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A more convenient and cheaper IR measurement is critical for prospective risk assessment, extensive population screening, and treatment monitoring. Triglyceride glucose-body mass index (TyG-BMI) is a new obesity-related parameter that has been developed in recent years, and it's obtained by multiplying TyG (composed of fasting plasma glucose and triglycerides) with BMI (derived from weight and height) (13)(14)(15)(16)(17)(18)(19)(20)(21). These are routine physical examination indicators that are easy to obtain.…”

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study

et al. 2022

View full text Add to dashboard Cite

BackgroundIt has been proved that triglyceride glucose-body mass index (TyG-BMI) is a readily available and clinically significant indicator of insulin resistance (IR). Nevertheless, the association between TyG-BMI and incident Type 2 diabetes mellitus (T2DM) remains uncertain. This study aimed to study the relationship between TyG-BMI and T2DM and explore the predictive characteristics of TyG-BMI.MethodsOur study was conducted as a longitudinal cohort study. 8,430 men and 7,034 women were enrolled and analyzed. They were both non-diabetic subjects with normal glycemic levels. Follow-up lasted for 13 years, from 1994 to 2016. To make the number of TyG-BMI in each group similar, the subjects were divided into four groups with 3866 subjects in each group.ResultsDuring the 13-year follow-up period, 373 subjects were diagnosed with incident T2DM. Our multivariate Cox regression analysis revealed that TyG-BMI was an independent predictor of incident T2DM. In addition, our research identified four specific groups, young people (18-44 years old), women, the non-hypertensive population and non-drinkers were at significantly higher risk of developing TyG-BMI-related diabetes (P-interaction< 0.05). The best threshold TyG-BMI for predicting incident T2DM was 197.2987 (area under the curve 0.7738).ConclusionsOur longitudinal cohort study demonstrated the positive correlation between baseline TyG-BMI and risk of incident T2DM in Japanese with normal glycemic levels, and this risk was significantly higher in the young people, women, the non-hypertensive population and non-drinkers.

show abstract

Section: Introductionmentioning

confidence: 99%

Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…They suggested that the function of the ratio was the combination of the two indicators and might exert a predictive value on the prevalence of NAFLD or other related metabolic disorders [7]. A recent cross-section study in a Chinese population of T2DM patients also found that in the overweight (BMI greater than 23 kg/m 2 ) subgroup, the GGT/HDL-C has a positive relationship with NAFLD incidence [35]. Our study is the rst to highlight the role of the GGT/HDL-C ratio in T2DM and further con rm a non-linear relationship.…”

Section: Discussionmentioning

confidence: 99%

The relationship between the ratio of gamma-glutamyltransferase to high-density lipoprotein cholesterol and the risk of diabetes mellitus using publicly available data: A secondary analysis based on a longitudinal study in Japan

Zhao

Xing

2022

Preprint

View full text Add to dashboard Cite

Background: The ratio of gamma-glutamyltransferase to high-density lipoprotein cholesterol (GGT/HDL-C) has been highlighted in nonalcoholic fatty liver disease (NAFLD) by previous studies. However, there have been fewer investigations into the correlation between the GGT/HDL-C ratio and the type 2 diabetes mellitus (T2DM) incidence. Our secondary analysis used published data from a Japanese population and aimed to investigate the role of the GGT/HDL-C ratio in the incidence of T2DM. Methods: The research was a longitudinal cohort study completed by Okamura, Takuro et al. We obtained the data from the DATADRYAD website and used it for secondary analysis only. The participants recruited from a medical program called the NAGALA database received regular medical examinations and standardized questionnaires to obtain the baseline variables. Abdominal ultrasound was used to diagnose fatty liver disease. The participants were followed up, and the duration and the occurrence of T2DM were documented. The GGT/HDL-C ratio evaluated at baseline served as the independent variable, while the occurrence of diabetes served as the dependent variable.Results: A total of 15,453 cases (8,419 men and 7,034 women) were included in our study. After adjusting for age, gender, BMI, DBP, SBP, ALT, AST, TG, T-CHO, HbA1C, FPG, drinking status, smoking status, exercise status, and fatty liver, we observed that GGT/HDL-C ratio was positively associated with the incidence of T2DM: (Hazard ratio = 1.005, 95% confidence interval:1.000 to 1.010, P = 0.0667). The results were consistent when the quartile GGT/HDL-C was used as a categorical variable (P for trend < 0.00396). A curvilinear relationship with a threshold effect was identified between GGT/HDL-C ratio and the risk of incident T2DM. On the left of the point, one unit increase in the GGT/HDL-C ratio was associated with a 1.5 times increase in the risk of incident T2DM (Hazard ratio 2.57, 95% confidence interval 1.20 to 5.49). On the right of the point, when GGT/HDL-C was greater than 6.53, their relationship turned to be saturated. Conclusion: The GGT/HDL-C ratio correlated with the incidence of T2DM in a curvilinear form with a threshold effect. Their positive relationship could be observed when the GGT/HDL-C was less than 6.53.

show abstract

“…Studies have confirmed that GGT 15 , HDL 16 , and NAFLD 17 , 18 are all associated with insulin resistance. Also, recent studies have found that increased levels of the GGT/HDL‐c ratio were strongly related to the risk of NAFLD and MAFLD 12 , 13 . Therefore, we propose that the GGT/HDL‐c ratio may affect the development of diabetes by mediating insulin resistance.…”

Section: Discussionmentioning

confidence: 99%

“…Some recent studies have found that high‐density lipoprotein cholesterol (HDL‐c) and γ‐glutamyl transpeptidase (GGT) were related to non‐alcoholic fatty liver disease (NAFLD) 5 , 6 , 7 , 8 and type 2 diabetes mellitus 9 , 10 , 11 risk. Two recent cross‐sectional studies have demonstrated that increased levels of the GGT/HDL‐c ratio were strongly associated with NAFLD and metabolic‐associated fatty liver disease (MAFLD) 12 , 13 . However, when reviewing the literature, we noticed no evidence of the connection between GGT/HDL‐c and the risk of type 2 diabetes.…”

Section: Introductionmentioning

confidence: 99%

Elevated gamma‐glutamyl transferase to high‐density lipoprotein cholesterol ratio has a non‐linear association with incident diabetes mellitus: A second analysis of a cohort study

Han

Guan

et al. 2022

J of Diabetes Invest

View full text Add to dashboard Cite

Objective Evidence regarding the association between the GGT/HDL‐c ratio and incident diabetes is still limited. On that account, our research aims to survey the link of the GGT/HDL‐c ratio with the risk of diabetes. Methods In this retrospective cohort study, data of 15,171 participants who participated in the medical examination program were collected in Murakami Memorial Hospital in Japan from 2004 to 2015. The independent and dependent variables were the baseline GGT/HDL‐c ratio and diabetes during the follow‐up, respectively. The Cox proportional‐hazards regression model was used to explore the association between the GGT/HDL‐c ratio and diabetes risk. A Cox proportional hazards regression with the cubic spline smoothing was used to recognize non‐linear relationships between the GGT/HDL‐c ratio and incident diabetes. Results After adjusting covariates, the results showed that the GGT/HDL‐c ratio was positively associated with incident diabetes (HR = 1.013, 95% CI: 1.002, 1.024). There was also a non‐linear relationship between the GGT/HDL‐c ratio and the risk of diabetes, and the inflection point of the GGT/HDL‐c ratio was 6.477. The HR on the left and right sides of the inflection point was 2.568 (1.157, 5.699) and 1.012 (1.001, 1.023), respectively. The sensitivity analysis demonstrated the robustness of the results. Besides, the performance of the FPG + GGT/HDL‐c ratio was better than FPG + GGT, FPG + HDL‐c, and FPG in predicting diabetes. Conclusion This study demonstrates a positive and non‐linear relationship between the GGT/HDL‐c ratio and incident diabetes in the Japanese population. The GGT/HDL‐c ratio is strongly related to diabetes risk when it is <6.477.

show abstract

Associations Between GGT/HDL and MAFLD: A Cross-Sectional Study

Cited by 27 publications

References 60 publications

Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study

Triglyceride Glucose-Body Mass Index and Risk of Incident Type 2 Diabetes Mellitus in Japanese People With Normal Glycemic Level: A Population-Based Longitudinal Cohort Study

The relationship between the ratio of gamma-glutamyltransferase to high-density lipoprotein cholesterol and the risk of diabetes mellitus using publicly available data: A secondary analysis based on a longitudinal study in Japan

Elevated gamma‐glutamyl transferase to high‐density lipoprotein cholesterol ratio has a non‐linear association with incident diabetes mellitus: A second analysis of a cohort study

Contact Info

Product

Resources

About