Association of angiotensin-converting enzyme insertion/deletion gene polymorphism with susceptibility of minimal change nephrotic syndrome in Asians: a meta-analysis

Tb, Zhou; Chen, Z; Yh, Qin; Hl, Xu

doi:10.1177/1470320312440902

Cited by 3 publications

(2 citation statements)

References 3 publications

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“…The pooled statistic was counted using the fixed effects model, but a random effects model was conducted when the p value of heterogeneity test was less than 0.1. [9][10][11] Results were expressed with odds ratios (ORs) for dichotomous data, and 95% confidence intervals (CIs) were also calculated. 12,13 The value of p<0.05 was required for the pooled OR to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED: Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy

Zhong

Zhong-liang

Yong

et al. 2014

J Renin Angiotensin Aldosterone Syst

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Section: Discussionmentioning

confidence: 99%

RETRACTED: Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy

Zhong

Zhong-liang

Yong

et al. 2014

J Renin Angiotensin Aldosterone Syst

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“…11,12 The ACE I/D polymorphisms have therefore been extensively studied in several adult CVDs, such as ischemic stroke, 13 coronary heart disease 14 and renal disease. [15][16][17][18] Over the past decade, a number of case-control studies have been conducted to clarify the association between ACE I/D polymorphisms and risk of ICH. However, previous studies investigating the association have reported conflicting results.…”

Section: Introductionmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: A meta-analysis of epidemiologic studies

Huang¹,

Li²,

Lan³

et al. 2013

J Renin Angiotensin Aldosterone Syst

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Studies investigating the association between the intron 16 insertion/deletion (I/D) polymorphism (rs4646994) in the angiotensin-converting enzyme (ACE) gene and risk of intracerebral hemorrhage (ICH) have reported conflicting results. We here performed a meta-analysis based on the evidence currently available from the literature to make a more precise estimation of this relationship. Published literature from the National Library of Medline and Embase databases were retrieved. Odds ratios (OR) and 95% confidence limits (CLs) were calculated in fixed-or random-effects models when appropriate. Subgroup analyses were performed by race. This meta-analysis included six case-control studies, which included 744 ICH cases and 1411 controls. The combined results based on all studies showed that ICH cases had a significantly lower frequency of ID genotype (OR (codominant model) = 0.43, 95% CL = 0.22, 0.84, p = 0.01). In the subgroup analysis by race, we found that ICH cases had a significantly lower frequency of II genotype in Asians (OR (recessive model) = 0.50, 95% CL = 0.38, 0.66, p < 0.001; OR (codominant model) = 0.25, 95% CL = 0.09, 0.71, p = 0.009). In conclusion, our meta-analysis suggests that ACE I/D polymorphisms are associated with ICH, especially in Asians.

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Association of Megsin gene polymorphism with IgA nephropathy risk

Zhou¹,

Mo²,

Kou

et al. 2014

Journal of Receptors and Signal Transduction

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This meta-analysis was conducted to assess the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with the risk of IgA nephropathy (IgAN). The association literatures were identified from PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) on 1 January 2014, and eligible reports were recruited and synthesized. Seven eligible reports were recruited into this meta-analysis for the association of Megsin 2093C/T, 2180C/T, C25663G gene polymorphism with IgAN risk. In this meta-analysis, the association of Megsin 2093C/T TT genotype with IgAN risk in Asians was found. Interestingly, Megsin C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, Megsin 2180C/T gene polymorphism was not associated with IgAN risk in Asians. In conclusion, Megsin 2093C/T TT genotype, and C25663G G allele and GG genotype were associated with the risk of IgAN in Asian population. However, more studies should be performed in the future to confirm this association.

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Association of angiotensin-converting enzyme insertion/deletion gene polymorphism with susceptibility of minimal change nephrotic syndrome in Asians: a meta-analysis

Cited by 3 publications

References 3 publications

RETRACTED: Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy

RETRACTED: Association of aldosterone synthase (CYP11B2) gene polymorphism with IgA nephropathy risk and progression of IgA nephropathy

Angiotensin-converting enzyme insertion/deletion gene polymorphisms and risk of intracerebral hemorrhage: A meta-analysis of epidemiologic studies

Association of Megsin gene polymorphism with IgA nephropathy risk

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