Association of Angiotensin-Converting Enzyme Gene
            <i>I/D</i>
            Polymorphism With Change in Left Ventricular Mass in Response to Physical Training

Montgomery, Hugh; Clarkson, Patrick; Dollery, C; Prasad, Krishna; Losi, Maria Angela; Hemingway, Harry; Statters, Deborah J.; Jubb, Mick; Girvain, Martin; Varnava, Amanda; World, Michael; Deanfield, John; Talmud, Phillipa; McEwan, Jean R.; McKenna, William J.; Humphries, S. E.

doi:10.1161/01.cir.96.3.741

Cited by 322 publications

(229 citation statements)

References 69 publications

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“…32 The definition of left ventricular hypertrophy varied widely among the 12 studies (Table 1). Three studies used ECG criteria to define left ventricular hypertrophy.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…Three studies used ECG criteria to define left ventricular hypertrophy. 14,15,32 In two studies, the diagnosis was based on the Sokolov-Lyon index (SV1 + RV5 or V6 у3.5 mV) combined or not with Minnesota code 3.1. (RV5, V6 Ͼ2.6 mV or R I, II, III, aVF у20 mV or RaVL Ͼ12 mV) or the Rautaharju criterion.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…(RV5, V6 Ͼ2.6 mV or R I, II, III, aVF у20 mV or RaVL Ͼ12 mV) or the Rautaharju criterion. 14,32 One study applied the point score system generated by the Marquette Software (Marquette Electronics, Inc, Milwaukee, WI, USA). 15 In nine studies, the presence or absence of left ventricular hypertrophy was diagnosed by echocardiographic criteria.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…With the exception of two studies in Japanese 15,37 and one American study 21 which included 25% of blacks, only whites were studied. 8,14,16,17,32,36,38,39 Of 16 groups, five included only men, 14,16,32,39 two included only women, 14,16 and eight had a mixed sex composition. 7,8,15,17,21,[36][37][38] The sex ratio was not given for cases and controls in five reports.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

“…42 Studies in which specific primers had been used 16,17,21,37 were contrasted with the remainder of the reports. 7,8,14,15,32,36,38,39 Odds of left ventricular hypertrophy associated with the D-allele In the first step of the analysis, allele frequencies were calculated (Table 3). Among cases and conJournal of Human Hypertension trols, the overall frequencies of the D allele were 0.54 (95% CI: 0.42 to 0.66) and 0.53 (95% CI: 0.31 to 0.65), respectively.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

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Antihypertensive treatment modulates the association between the D/I ACE gene polymorphism and left ventricular hypertrophy: a meta-analysis

et al. 2000

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This meta-analysis attempted to derive pooled estimates for the putative association between echocardiographic or electrocardiographic left ventricular hypertrophy and the deletion/insertion (D/I) polymorphism of the angiotensin-I converting enzyme. Casecontrol studies were combined, using the Mantel and Haenszel approach. Joint P-values for continuous variables were calculated by Stouffer's method. Continuous measurements of left ventricular mass, which were reported in different units, were expressed on a percentage scale using the within-study mean of the II genotype as the denominator. The computerised database used for this analysis, included 28 reports with an overall sample size of 6638 subjects. The prevalence of the D allele was significantly lower in Japanese (37.2%) than in Caucasians (56.2%). A funnel plot including 12 casecontrol studies (4094 subjects) suggested that no publication bias was present. Overall, left ventricular hypertrophy was not associated with the D allele. Compared with the II genotype, the excess risks of left ventricular hypertrophy associated with DD and DI geno-

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“…32 The definition of left ventricular hypertrophy varied widely among the 12 studies (Table 1). Three studies used ECG criteria to define left ventricular hypertrophy.…”

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%

Section: Methodological Assessment Of the Case-control Studiesmentioning

confidence: 99%