Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes

Zarouk, Waheba A.; Hussein, Ibtessam R; Esmaiel, Nora N.; Raslan, Hala M.; Reheim, H A A; Moguib, Omneya; Emara, Nahed; Aly, Azza Ahmed; Hamed, Mona

doi:10.4149/bll_2012_003

Cited by 41 publications

(47 citation statements)

References 21 publications

(22 reference statements)

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“…Many studies showed that polymorphisms of certain genes related to metabolism, including that of ACE, are also associated with the onset and development of Type 2-Diabetes [22, 24 -25]. There is a 287 bp DNA fragment insertion (I) and /or deletion(D) polymorphism in the intron 16 of ACE gene [22,26], which was recently studied [27][28][29][30][31] …”

Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

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The Renin-Angiotensin System (RAS) is an important regulator of the blood pressure(BP). The level of the vasoactive peptide Angiotensin-II, is mainly determined by the RAS enzyme, angiotensin converting enzyme-1 (ACE-1). Polymorphisms in ACE gene is reported to be associated with hypertension in various populations worldwide. We investigated the association of ACE I/D polymorphisms with hypertension among the tribal populations of South India. Samples were collected from hypertensive patients (n = 33) and healthy controls (n = 37). Genotyping was performed using Polymerase chain reaction (PCR) with allele specific primers. The DD genotype is significantly observed among the cases (OR = 1.0) . Specifically, the DD genotype is more evident among the females (OR = 0.705) than males (OR = 1.22) and is analysed to be associated with hypertension among the tribal populations of South India.

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Section: Introductionmentioning

confidence: 99%

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Paramasivam

Nandakumar

Arumugam

et al. 2016

ILNS

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“…Doprinos istraživanju genetike metaboličkog sindroma u shizofreniji proizlazi i iz dviju studija nedavno provedenih u hrvatskoj populaciji koje su ispitale povezanost funkcijskog insercijsko-delecijskog polimorfizma (I/D) gena za angiotenzinkonvertirajući enzim (ACE) i funkcijske polimorfne varijante L162V u genu za PPARα s vrijednostima BMI-ja, te s koncentracijama glukoze i lipida u plazmi, u dvjestotinjak pacijenata sa shizofrenijom i shizoafektivnim poremećajem 153,154 . Spomenute polimorfne varijante prethodno su istražene povezano s metaboličkim sindromom ili njegovim komponentama u velikom broju studija u općoj populaciji, međutim, ne i u pacijenata sa shizofrenijom [155][156][157][158][159][160] . Značajno više vrijednosti glukoze u plazmi pronađene su u pacijentica heterozigota za ACE genotip (ID) u odnosu na pacijentice ACE-DD i ACE-II homozigote, dok su muškarci koji su u svojem ACE genotipu posjedovali D alel (ACE-DD homozigoti i ACE-ID heterozigoti) pokazali zanimljiv trend prema većim vrijednostima triglicerida 154 .…”

Section: Genetika Metaboličkog Sindroma U Shizofrenijiunclassified

Etiopathogenesis of metabolic syndrome in schizophrenia – recent findings

et al. 2017

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Sažetak. Uzrok polovice do dvije trećine smrtnih ishoda pacijenata sa shizofrenijom pripisuje se kardiovaskularnim bolestima. Smatra se da visoka učestalost metaboličkog sindroma najviše povećava rizik za nastanak kardiovaskularnih oboljenja u shizofreniji. Iako je metabolički sindrom jedan od vodećih uzroka morbiditeta i mortaliteta u pacijenata sa shizofrenijom, do prije petnaestak godina istraživanje etiologije metaboličkog sindroma u shizofreniji nije predstavljalo veći znanstveni interes. Novije spoznaje ukazuju na mogućnost da bi pojačano stanje upalnog odgovora u organizmu moglo predstavljati zajedničku etiopatogenetsku podlogu u nastanku metaboličkog sindroma i shizofrenije. Primjerice, značajno povišena koncentracija proupalnih citokina te C reaktivnog proteina uočena je u pacijenata sa shizofrenijom koji nisu uzimali antipsihotične lijekove ili su ih uzimali u vrlo malim dozama, a zamijećeno je i da uzimanje inhibitora ciklooksigeneze-2, uz antipsihotičnu terapiju, može ublažiti težinu kliničkih simptoma i kognitivnih deficita u oboljelih. U ovom preglednom radu iznesene su najnovije spoznaje o ulozi okolišnih i genetičkih čimbenika u etiopatogenezi metaboličkog sindroma u shizofreniji. Mnogi mehanizmi kojima bi okolišni čimbenici, poput nezdrave prehrane i pušenja, mogli pridonijeti nastanku metaboličkog sindroma u shizofreniji ne razlikuju se značajno u odnosu na opću populaciju. Ipak, uzimanje antipsihotičnih lijekova, posebice tzv. atipičnih antipsihotika, te njihova interakcija s okolišnim čimbenicima, kao i genetičkim čimbenicima podložnosti, dodatno pridonose heterogenosti etiopatogeneze metaboličkog sindroma u shizofreniji, ali i otežavaju adekvatan terapijski pristup. Budući da su dosadašnja istraživanja uglavnom bila usredotočena na moguću poveznicu antipsihotičnih lijekova i metaboličkih abnormalnosti u oboljelih, detaljnije su razmotrene značajke nezdrave prehrane i ovisnosti o pušenju te njihova moguća povezanost s metaboličkim sindromom.Ključne riječi: antipsihotični lijekovi; genetika; prehrana; pušenje; shizofrenija Abstract. The etiology of one half to two-thirds of deaths among patients with schizophrenia could be attributed to cardiovascular diseases. It is believed that high prevalence of metabolic syndrome mostly contributes to the risk of cardiovascular diseases in schizophrenia. Although the metabolic syndrome is among the leading causes of morbidity and mortality among patients with schizophrenia, fifteen years ago studies investigating the etiology of the metabolic syndrome among patients with schizophrenia were not a part of scientific interest. Recent findings indicate the possibility that increased state of inflammatory response in the organism may underlie the etiopathogenesis of both schizophrenia and metabolic syndrome. For instance, significantly increased levels of proinflammatory cytokines and C reactive protein have been observed in schizophrenia patients with minimal or no exposure to antipsychotics and it has also been revealed that cyclooxygenase-2 inhibitor drugs ...

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“…However, the results obtained according to different areas of studies are still contradictory. In Japan (Higaki et al, 2000) and India (Zarouk et al, 2012), DD genotype significantly increased risk of developing EH. Whereas no effect of the presence of DD genotype was observed in Dutch (Schidmt et al, 1993), Tunisian (Kabadou et al, 2013), and Indonesian (Rasyid et al, 2012) populations.…”

Section: Introductionmentioning

confidence: 97%

Insertion/deletion gene variants of angiotensin converting enzyme do not predispose cameroonians of the Bantu ethnic group to essential hypertension

Ghogomu¹,

Tamutan²,

Musong³

2016

Int. J. Bio. Chem. Sci

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The insertion/deletion (I/D) polymorphism in the angiotensin-converting enzyme gene has been reported to be implicated in the predisposition to essential hypertension (EH). This association may depend on ethnic and genetic backgrounds. The objective of this study was to determine if the possible I/D polymorphism in the Bantu ethnic group of Cameroon is associated with EH. Data were analyzed from 60 patients and 50 healthy controls in order to access the risk factors of EH in this ethnic group. Comparison of gene and allele frequency distributions between the two populations revealed that systolic and diastolic blood pressures, age, family history and lack of physical exercise were risk factors of EH in this ethnic group. Comparison of means of age, systolic and diastolic blood pressures as well as the proportions of individuals with a family history of EH and lack of physical exercise were higher in the hypertensive than the normotensive group (p < 0.05). In addition, Comparison of genotype and allele frequencies between the two populations did not reveal statistically significant differences (p > 0.05). Moreover, analyses of relationship between ACE I/D gene variants and EH did not reveal any association (p > 0.05). Consistently, the two groups also did not present with differences in I and D allele distribution (p > 0.05). These results suggest that EH is not associated with ACE I/D polymorphism.

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Association of angiotensin converting enzyme gene (I/D) polymorphism with hypertension and type 2 diabetes

Cited by 41 publications

References 21 publications

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Association of ACE <i>DD</i> Genotype with Hypertension among the Tribal Populations of South India

Etiopathogenesis of metabolic syndrome in schizophrenia – recent findings

Insertion/deletion gene variants of angiotensin converting enzyme do not predispose cameroonians of the Bantu ethnic group to essential hypertension

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