Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population

Ghafar, Muhammad Tarek Abdel

doi:10.1080/10641963.2018.1557679

Cited by 21 publications

(9 citation statements)

References 31 publications

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“…Moreover, 2 DM increased the risk of CKD 2.4 times, obesity (BMI >30 kg/m 2 ) -2.08 and 2.32 times as much. Furthermore, the 3 rd grade of BP elevation (SBP ≥180 Hg mm and/or DBP ≥110 Hg mm) increased the CKD probability threefold, which partially correlates with multiple studies and confirms our certain results published earlier [14][15][16][23][24][25][26].…”

Section: Discussionsupporting

confidence: 91%

“…The CYP11B2 gene in humans is very polymorphic with 227 single nucleotide polymorphisms (SNP) described in different populations. Bi-allele polymorphism in the CYP11B2 gene promoter in the position -344 (-344C/T) is associated with EAH [14,15], especially T-allele (-344T) [16], or salt-dependent hypertension [17], development of aldosterone-producing adenoma [18][19][20] [16], etc., which corresponded to the obtained results. Our studies found relations between -344C/T polymorphism of CYP11B2 gene and EAH occurrence (especially in T-allele carriers' women).…”

Section: Discussionmentioning

confidence: 99%

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The cytochrome 11B2 aldosterone synthase gene CYP11B2 (RS1799998) polymorphism associates with chronic kidney disease in hypertensive patients

2020

Biointerface Res Appl Chem

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Renin-angiotensin aldosterone system (RAAS) holds a crucial role in blood pressure regulation. Aldosterone is encoded by the cytochrome 11B2 aldosterone synthase gene (CYP11B2). The study aim was to analyze the association of Chronic Kidney Disease (CKD) with allelic polymorphism of the CYP11B2 at position -344 (-344C/T) in the promoter in patients with essential arterial hypertension (EAH). 72 subjects with EAH and target-organ damaging (2nd stage), moderate, high or very high cardiovascular risk were involved in the case-control study. Among them, 70.83% (51) females and 29.17% (21) males, mean age 59.87±8.02 yo; disease duration from 6 to 25 years. CKD was determined by the National Kidney Foundation recommendations (Kidney Disease: Improving Global Outcomes (KDIGO), 2012) after glomerular filtration rate (GFR) decline <60 ml/min/1,73 m2 for over 3 months (by Cockroft-Gault formula and CKD-EPI for Cystatin-C and Creatinine serum levels depending on gender). CKD was diagnosed in 29 persons. Control group consisted of fourty-eight practically healthy individuals of relevant age. Gene polymorphism of aldosterone synthase gene CYP11B2 (-344C/T) was examined by polymerase chain reaction (PCR). The probability of EAH in the observed population increased 1.49 times in T-allele carriers of CYP11B2 gene, but only in females [OR=1.90; 95%CI:1.02-3.54; р=0.029], with contrary decreasing in C-allele women (p=0.041). Moreover, T-allele increased probability of CKD (GFR<60 ml/min/1,73m2) in hypertensive population 1.48 times [OR=1.86; 95%CI:1.01-3.58; р=0.049], especially in T-allele females 1.53 times [OR=6.51; 95%CI:1.39-30.60; р=0.007] with low CKD risk in T-allele males [OR=0.15; 95%CI:0.03-0.72; р=0.009], respectively. Furthermore, some predictors like Diabetes, the 2nd and 3rd grades Obesity, and the 3rd grade of Blood Pressure elevation escalated the risk of CKD 2.4, 2.08-2.32 and 2.91 times, accordingly (p<0.05). Thus, aldosterone synthase gene CYP11B2 (-344C/T) associated with EAH. T-allele increased risk of CKD in hypertensive population, especially in females.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

The cytochrome 11B2 aldosterone synthase gene CYP11B2 (RS1799998) polymorphism associates with chronic kidney disease in hypertensive patients

2020

Biointerface Res Appl Chem

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“…As previously indicated, the CYP11B2 TT genotype was associated with higher plasma aldosterone levels. 14 – 16 However, the CYP11B2 -344T/C polymorphism was not associated with TIA occurrence in our study. In this study, we only investigated the association between one single polymorphism and TIA, and the influence of gene–gene or gene–environment interaction was not considered.…”

Section: Discussioncontrasting

confidence: 77%

Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population

et al. 2020

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Objective This study investigated whether the CYP11B2 -344T/C polymorphism is correlated with transient ischemic attack (TIA) susceptibility. Methods We recruited 100 TIA patients and 100 control subjects and analyzed the CYP11B2 -344T/C polymorphism using restriction fragment length polymorphism (PCR–RFLP). Results The frequency in TIA patients and controls was 42% compared with 48% for TT genotypes, 51% compared with 45% for TC genotypes, and 7% compared with 7% for CC genotype, respectively. Allele frequencies in TIA patients and controls were 67.5% compared with 70.5% for T-allele and 32.5% compared with 29.5% for C-allele, respectively. No association between the CYP11B2 -344T/C polymorphism and TIA was observed in all comparisons. Conclusion Our data suggest that there was no association between the CYP11B2 -344T/C polymorphism and TIA in a Chinese population.

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“…Although major final outcome of CVD such as death and cardiovascular disability do not occur in hypertensive children, they are encountered with increased risk of intermediate markers of target organ damage, such as left ventricular hypertrophy, retinal vascular changes, thickening of the carotid vessel wall, and even subtle cognitive changes [ 4 ]. It is widely recognized that blood pressure levels are influenced by genetic as well as by environmental factors [ 5 , 6 ]. In this regard, more than 90 different genetic polymorphisms have been identified to be associated with high blood pressure [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, a recent study reported that polymorphism of aldosterone synthase gene is linked with the development of hypertension through increasing the aldosterone level and aldosterone/renin ratio [ 5 ]. On the other hand, among environmental parameters, obesity, smoking, alcohol consumption, diet, and physical inactivity likely play a major role in development of hypertension [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Sugar-sweetened beverages increases the risk of hypertension among children and adolescence: a systematic review and dose–response meta-analysis

2020

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Background: In the current systematic review and meta-analysis, we summarized the studies that evaluated the effects of sugar-sweetened beverages (SSBs) intake on blood pressure among children and adolescents. Methods: In a systematic search from PubMed, Scopus, Embase and Cochrane electronic databases up to 20 April 2020, the observational studies that evaluated the association between sugar-sweetened beverages intake and hypertension, systolic or diastolic blood pressure (SBP, DBP) were retrieved. Results: A total of 14 studies with 93873 participants were included in the current meta-analysis. High SSB consumption was associated with 1.67 mmHg increase in SBP in children and adolescents (WMD: 1.67; CI 1.021-2.321; P < 0.001). The difference in DBP was not significant (WMD: 0.313; CI −0.131-0.757; P = 0.108). High SSB consumers were 1.36 times more likely to develop hypertension compared with low SSB consumers (OR: 1.365; CI 1.145-1.626; P = 0.001). In dose-response meta-analysis, no departure from linearity was observed between SSB intake and change in SBP (P-nonlinearity = 0.707) or DBP (P-nonlinearity = 0.180). Conclusions: According to our finding, high SSB consumption increases SBP and hypertension in children and adolescents.

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Association of aldosterone synthase CYP11B2 (-344C/T) gene polymorphism with essential hypertension and left ventricular hypertrophy in the Egyptian population

Cited by 21 publications

References 31 publications

The cytochrome 11B2 aldosterone synthase gene CYP11B2 (RS1799998) polymorphism associates with chronic kidney disease in hypertensive patients

The cytochrome 11B2 aldosterone synthase gene CYP11B2 (RS1799998) polymorphism associates with chronic kidney disease in hypertensive patients

Lack of association between CYP11B2 -344T/C polymorphism and transient ischemic attack in a Chinese population

Sugar-sweetened beverages increases the risk of hypertension among children and adolescence: a systematic review and dose–response meta-analysis

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