Association of Alcohol Intake With Pancreatic Cancer Mortality in Never Smokers

Gapstur, Susan M.; Jacobs, Eric J.; Deka, Anusila; McCullough, Marjorie L.; Patel, Alpa V.; Thun, Michael J.

doi:10.1001/archinternmed.2010.536

Cited by 69 publications

(74 citation statements)

References 33 publications

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“…Thus these results are representative of the US population. The mean risk of death in the study population for pancreas cancer was 0 .0014 ( Alcohol consumption has been associated with increased pancreas cancer mortality (Gapstur et al, 2011) and this was confirmed here. This study found the relationship between poverty and pancreas cancer death was more complex.…”

Section: Discussionsupporting

confidence: 82%

Serum Hepatitis a Antibody Positivity Correlates with Higher Pancreas Cancer Mortality in Adults: Implications for Hepatitis Vaccination in High Risk Areas

Cheung¹

2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 82%

Serum Hepatitis a Antibody Positivity Correlates with Higher Pancreas Cancer Mortality in Adults: Implications for Hepatitis Vaccination in High Risk Areas

Cheung¹

2013

Asian Pacific Journal of Cancer Prevention

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“…3 Never exposed to HBV. 4 Chronic carrier of HBV. 5 Previously exposed to HBV with immunity, but possibly harboring persistent HBV infection.…”

Section: Discussionmentioning

confidence: 99%

“…1 Almost all patients die of the disease within 1 year of the diagnosis, with conventional treatments having little impact on disease course. Several risk factors associated with pancreatic cancer have been explored, including genetic, 2 cigarette smoking, 3 alcohol intake, 4 chronic pancreatitis, 5 diabetes mellitus, 6 obesity, 7 first-degree relatives of pancreatic cancer 8 and Helicobacter pylori infection. 9 Nevertheless, these factors account only for a minority of cases, the causative environmental and genetic factors for pancreatic cancer still remain unknown.…”

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confidence: 99%

ABO blood group, hepatitis B viral infection and risk of pancreatic cancer

Wang

Chen

Ren

et al. 2011

Intl Journal of Cancer

115

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Little is known about the role of association between ABO blood type and risk of pancreatic cancer develops through effects on hepatitis B viral (HBV) infection. Our study aimed to determine whether joint ABO blood type and HBV infection could increase the risk for pancreatic cancer. A total of 645 patients with pancreatic adenocarcinoma and 711 age-and sex-matched individuals who had nonmalignant diseases treated at the Sun Yat-sen University Cancer Center in China were retrospectively analyzed. Blood samples were tested for ABO blood type and hepatitis B surface antigen (HBsAg), hepatitis B surface antibody (anti-HBs), hepatitis B e antigen (HBeAg), hepatitis B e antibody (anti-HBe) and hepatitis B core antibody (anti-HBc). Multivariable unconditional logistic regression analysis was used to estimate adjusted odds ratios [AORs] and 95% confidence interval [CI]. Multivariable analysis with adjustment for risk factors showed that A blood type, HBsAg-positive/anti-HBcpositive, anti-HBs-positive/anti-HBc-positive were significantly associated with pancreatic cancer. The estimated AORs (95% CI) were as follows: A blood type, 1.425 (1.071-1.894), HBsAg-positive/anti-HBc-positive, 1.610 (1.125-2.304), anti-HBspositive/anti-HBc-positive, 1.526 (1.159-2.011). The effect of A blood type significantly modified the risk of pancreatic cancer among subjects with anti-HBc-positive (AORs 5 1.882, 95% CI, 1.284-2.760). In our study, we reported an association between A blood type, infection with HBV and pancreatic cancer risk. Moreover, we found a synergism between A blood type and HBV infection in the development of pancreatic cancer.Pancreatic cancer is the fifth most common cancer and the fourth leading cause of cancer-related mortality worldwide.

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“…Early identification of individuals at high risk for pancreatic adenocarcinoma could have a marked impact on reducing morbidity and mortality. Several risk factors associated with pancreatic cancer have been identified, including genetic factors [5], cigarette smoking [6,7,8,9], alcohol intake [10], chronic pancreatitis [11,12], diabetes mellitus [13,14], and obesity [15,16,17]. However, most of these risk factors were identified by systematic reviews of Western studies, and risk factors for pancreatic adenocarcinoma in China have rarely been reported.…”

Section: Introductionmentioning

confidence: 99%

Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

Chen

et al. 2012

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Background: Metabolic syndrome is a complex collection of interrelated conditions. Recent data have shown that metabolic syndrome may play a role in several cancers. Pancreatic adenocarcinoma is the fourth most common cause of death from cancer in the United States and the fifth in Europe. Despite the increasing numbers of published studies, the etiology of pancreatic adenocarcinoma is incompletely defined. Therefore, this paper aims to evaluate the risk factors for pancreatic adenocarcinoma. Methods: This was a case-control study of pancreatic adenocarcinoma patients who were referred to the Peking Union Medical College Hospital. Controls were randomly selected from an existing database of healthy individuals at the Health Screening Center. Data on metabolic syndrome, pancreatic diseases, liver diseases, and a history of diabetes and history of hypertension were collected either by conducting a retrospective review of the patients’ records and health examination reports or by interview. Results: A history of smoking (OR = 2.981), diabetes (OR = 2.421), cholecystolithiasis (OR = 5.453), or chronic pancreatitis (OR = 28.264) as well as the levels of fasting blood glucose (OR = 4.241), total cholesterol (OR = 1.793), and apolipoprotein A (OR = 36.065) were significantly related to pancreatic adenocarcinoma. Conclusions: Cholelithiasis, chronic pancreatitis, and certain metabolic syndrome components are potential risk factors for the development of pancreatic adenocarcinoma.

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Association of Alcohol Intake With Pancreatic Cancer Mortality in Never Smokers

Abstract: These results strengthen the evidence that alcohol consumption, specifically liquor consumption of 3 or more drinks per day, increases pancreatic cancer mortality independent of smoking.

Cited by 69 publications

References 33 publications

Serum Hepatitis a Antibody Positivity Correlates with Higher Pancreas Cancer Mortality in Adults: Implications for Hepatitis Vaccination in High Risk Areas

Serum Hepatitis a Antibody Positivity Correlates with Higher Pancreas Cancer Mortality in Adults: Implications for Hepatitis Vaccination in High Risk Areas

ABO blood group, hepatitis B viral infection and risk of pancreatic cancer

Metabolic Syndrome Components and Risk Factors for Pancreatic Adenocarcinoma: A Case-Control Study in China

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