Association of age-related macular degeneration with age-related hearing loss

Bozkurt, Mete Kaan; Öztürk, Bayram; Kerimoğlu, Hürkan; Erşan, İsmail; Arbağ, Hamdi; Bozkurt, Birkan

doi:10.1017/s0022215110002604

Cited by 10 publications

(13 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Concerning SNHL and ocular diseases, age-related SNHL has been reported with a higher occurrence rate in those with age-related macular degeneration [34], while optic neuropathy and SNHL presented with same gene defect [35]. However, few studies have focused on the correlation between glaucoma and SNHL.…”

Section: Discussionmentioning

confidence: 99%

Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study

Chien

Wang

et al. 2019

IJERPH

View full text Add to dashboard Cite

The purpose of the current study was to evaluate the incidence of glaucoma in patients diagnosed with sensorineural hearing loss (SNHL) via the application of the National Health Insurance Research Database in Taiwan. A retrospective cohort study was conducted. Patients with a diagnosis of SNHL were enrolled in the study group after an exclusion procedure and a propensity score matched group without SNHL was served as the control group with a 1:2 ratio. The main outcome was regarded as the emergence of glaucoma diagnostic codes. Cox proportional hazard regression was applied to analyze the incidence and adjusted hazard ratio (aHR) of glaucoma in the multivariate model. A total of 15,686 patients diagnosed with SNHL were enrolled in the study group while another 31,372 non-SNHL individuals served as the control group. There were 444 glaucoma events in the study group and 647 glaucoma events in those non-SNHL individuals after the follow-up interval of 16 years. The study group demonstrated a significantly higher aHR compared to the control group after adjusting for multiple possible risk factors. In the subgroup analysis, both the normal tension glaucoma and angle closure glaucoma subgroups revealed a higher aHR in the study group. In conclusion, the patients with SNHL demonstrated a higher incidence of developing glaucoma. Moreover, the incidence was more prominent for patients diagnosed with normal tension glaucoma and angle closure glaucoma.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study

Chien

Wang

et al. 2019

IJERPH

View full text Add to dashboard Cite

show abstract

“…Few previous studies have shown this significant association between ARMD and hearing impairment. [ 27 29 30 ] We also outlined the hypothesis of possible similar roles for melanin in development of these two disorders in the retina and inner ear. Moreover, subjective signs of hearing impairment in ARMD patients were investigated.…”

Section: Discussionmentioning

confidence: 99%

“…They also did not explain the mechanisms by which late ARMD and hearing impairment may theoretically be associated. [ 27 32 ]…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was calculated based on the standard sample size formula and similar studies in the literature. [ 27 ] A retina subspecialist confirmed the diagnosis in each patient by precise direct and/or indirect ophthalmoscopy, FA (Heidelberg eye explorer HRA2, Spectralis, Heidelberg, Germany) and OCT (Topcon 3D OCT 1000, Topcon Corporation, Tokyo, Japan) using the early age-related maculopathy (ARM) international classification system and Wisconsin Age-Related Maculopathy Grading Scheme (WARMGS). [ 8 28 ] Based on this classification, in one or both eyes, patients who had only or predominantly drusen were considered as the drusen group.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Association of age related macular degeneration and age related hearing impairment

Ghasemi

Pourakbari

Entezari

et al. 2016

J Ophthalmic Vis Res

View full text Add to dashboard Cite

Purpose:To evaluate the association between age-related macular degeneration (ARMD) and sensory neural hearing impairment (SHI).Methods:In this case-control study, hearing status of 46 consecutive patients with ARMD were compared with 46 age-matched cases without clinical ARMD as a control group. In all patients, retinal involvements were confirmed by clinical examination, fluorescein angiography (FA) and optical coherence tomography (OCT). All participants were examined with an otoscope and underwent audiological tests including pure tone audiometry (PTA), speech reception threshold (SRT), speech discrimination score (SDS), tympanometry, reflex tests and auditory brainstem response (ABR).Results:A significant (P = 0.009) association was present between ARMD, especially with exudative and choroidal neovascularization (CNV) components, and age-related hearing impairment primarily involving high frequencies. Patients had higher SRT and lower SDS against anticipated presbycusis than control subjects. Similar results were detected in exudative, CNV and scar patterns supporting an association between late ARMD with SRT and SDS abnormalities. ABR showed significantly prolonged wave I and IV latency times in ARMD (P = 0.034 and 0.022, respectively). Average latency periods for wave I in geographic atrophy (GA) and CNV, and that for wave IV in drusen patterns of ARMD were significantly higher than controls (P = 0.030, 0.007 and 0.050, respectively).Conclusion:The association between ARMD and age-related SHI may be attributed to common anatomical components such as melanin in these two sensory organs.

show abstract

“…Bozkurt et al reported recently that age-related hearing loss is more common in patients with AMD who are aged 50 years or older. AMD and age-related hearing loss share common underlying chronological and biological aging and/or disease processes, possibly because of common genetic, environmental, or lifestyle factors (e.g., exposure to oxidative stress, atherosclerosis, high cholesterol levels, or a history of heavy drinking, smoking, or occupational exposure to noise) (Bozkurt et al, 2011). It was also reported recently that gadolinium contrast agents injected intravenously appeared in the affected inner ear on magnetic resonance imaging (Yoshida et al, 2008), suggesting that disruption of the blood-labyrinth barrier or increased permeability of blood vessels in the inner ear, which is associated with the inflammatory response, is found in one-third of patients with SSNHL.…”

Section: Introductionmentioning

confidence: 99%

Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes

Nishio

Teranishi

Uchida

et al. 2012

Gene

View full text Add to dashboard Cite

Association of age-related macular degeneration with age-related hearing loss

Abstract: Age-related hearing loss is more common in patients with age-related macular degeneration. Such patients should be questioned regarding hearing difficulty, and referred to an otolaryngologist if appropriate.

Cited by 10 publications

References 14 publications

Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study

Increased Incidence of Glaucoma in Sensorineural Hearing Loss: A Population-Based Cohort Study

Association of age related macular degeneration and age related hearing impairment

Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes

Contact Info

Product

Resources

About