Association of Adult Attention Deficit Hyperactivity Disorder With Dopamine Transporter Gene, Dopamine D3 Receptor, and Dopamine D4 Receptor Gene Polymorphisms

Sevinc, Erinc; Şengül, Cem; Çakaloz, Burcu; Ergundu, Tuba Gokdogan; Herken, Hasan

doi:10.1080/10177833.2010.11790660

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Amerika'da ve Avrupa'da ve ülkemizde yürütülen çeşitli çalışmalarda DEHB'li çocuklarda ve sağlıklı kontrollerde allel sıklığı değişmekle birlikte en yaygın allelin 4 tekrar alleli olduğu; en yaygın ikinci allelin ise 7 tekrar alleli olduğu gösterilmiştir. [20,21] 7 tekrar alleli sıklığının asya toplumunda daha düşük olduğu bildirilmektedir. [22] Çin'de yapılan bir çalışmada DEHB tanılı çocukların hiçbirinde 7 tekrar alleli saptanmamış, buna karşın 4 ya da 2 tekrar alleli sıklığının daha fazla olduğu bulunmuştur.…”

Section: Dopamin Reseptör Genleriunclassified

Candidate Gene Studies of Attention Deficit Hyperactivity Disorder

Güney¹,

Ceylan²,

İşeri³

2011

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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Dikkat eksikliği hiperaktivite bozukluğu (DEHB) çocuklarda %5-10 oranında görülen yaygın bir psikiyatrik rahatsızlıktır. Bu hastalık dikkat eksikliği ve hiperaktivite/dürtüsellik belirtilerinin bileşimi olarak tanımlanmıştır. İkiz çalışmalarında DEHB'nin yüksek derecede kalıtılabirliğinin kanıtlanmış, yapılan moleküler genetik çalışmalarda da DEHB'de karmaşık bir genetik yapı olduğu tespit edilmiştir. Moleküler genetik çalışmalar, bu kompleks hastalığın etyolojisinde dopaminerjik, serotonerjik ve noradrenerjik nörotransmisyondaki sorunlardan kaynaklandığını göstermektedir. Bu çalış-mada DEHB'nin moleküler genetiği ile ilgili en son bulgular kapsamlı olarak gözden geçirilmiştir. Anahtar Sözcükler: DEHB, genetik, aday gen çalışmaları, etyoloji ABSTRACT Attention-deficit/hyperactivity disorder (ADHD) is a common psychiatric condition that affects approximately 5-10% of children worldwide. This disorder is defined by a combination of symptoms of inattention and hyperactivity/impulsivity. Although twin studies demonstrate that ADHD is a highly heritable condition, molecular genetic studies suggest that the genetic architecture of ADHD is complex. Molecular genetic studies support the thesis that dopaminergic, serotonergic, and noradrenergic neurotransmission pathways account for the etiology of this complex disease. This article reviews the latest findings on the molecular genetics of ADHD.

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Section: Dopamin Reseptör Genleriunclassified

Candidate Gene Studies of Attention Deficit Hyperactivity Disorder

Güney¹,

Ceylan²,

İşeri³

2011

Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychia

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“…Attention deficit hyperactivity disorder (ADHD) is one of the most common psychiatric problems in school age children (1). ADHD is a complex and heterogeneous disorder with unknown etiology (2,3). In other words, ADHD is considered a multifactorial disorder, and its contributing factors include psychological, environmental, and genetic factors (4).…”

Section: Introductionmentioning

confidence: 99%

Analysis of Association Between the Effects of Methylphenidate and DRD4 Gene Polymorphisms in Patients with Attention Deficit Hyperactivity Disorder

et al. 2021

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Background: Drug treatment is one of the most important treatments for attention deficit hyperactivity disorder (ADHD). The DRD4 gene is a transporter and receptor coding gene of dopamine and is one of the most important genes under investigation in the disorder and etiology of ADHD. In this study, the association between rs3758653 C/T and VNTR exon 3 repetition polymorphisms of the DRD4 gene and the effects of methylphenidate were investigated in patients with ADHD disorder consuming methylphenidate. Methods: The descriptive-analytical study was performed on 122 patients (5 - 18 years old) with ADHD who were treated with methylphenidate. DNA was extracted using salting out method. Subsequently, the rs3758653 polymorphism in the 5'UTR region of DRD4 gene was genotyped by PCR-RFLP method, and the VNTR fragment in exon III of DRD4 gene was investigated by electrophoresis gel on acrylamide gel method. After eight weeks from the start of drug treatment with methylphenidate, the intensity of symptoms was evaluated using the Conners scale. Finally, all data from questionnaires and information that were resulted from laboratory findings were analyzed using ANOVA and repeated measure analysis. Results: Of the 122 patients under study, 15 patients (12.3%) were responded to the drug treatment, and 107 patients (87.7%) were not responded. The significant differences were not revealed in genotype, and allele frequencies of between rs3758653 (C/T) and exon III 3'VNTR repeats polymorphisms of the DRD4 gene and responder and non-responder of ADHD groups to the drug treatment. Conclusions: The results showed that the reduction of ADHD symptoms with drug treatment is not related to DRD4 sub-types in patients with ADHD.

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Association study between the dopamine-related candidate gene polymorphisms and ADHD among Saudi Arabia population via PCR technique

et al. 2012

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Attention deficit hyperactivity disorder (ADHD) is one of the most common childhood behavioral disorders characterized by inattention, hyperactivity and impulsivity. In Saudi Arabia the prevalence of combined ADHD is 16.4 %. ADHD etiology is not clear and not completely understood. There are several evidences for involvement of dopaminergic, serotonergic and noradrenergic neurotransmitter systems in the pathogenesis of ADHD. Monoamine Oxidase A (MAOA) is involved in the degradation of all three of these neurotransmitters. Dopamine Transporter 1 (DAT1) plays an important role in controlling blood levels of dopamine. The aim of the present study is to investigate the association between ADHD and polymorphisms of MAOA 30 bp-promoter VNTR and DAT1 40 bp 3' UTRVNTR in Saudi population. PCR technique was employed to detect polymorphisms of MAOA and DAT1 genes in a sample of 120 ADHD subjects and 160 controls. Alleles and genotypes frequencies for both of MAOA and DAT1 polymorphisms were compared among ADHD subjects against controls. Association between ADHD and alleles as well as genotypes for each studied polymorphisms was tested by odds ratio (OR) test and the magnitude of this association was estimated by 95 % confidence interval (95 % CI). A significant association was found between two MAOA genotypes 3/4 and 3/2 with ADHD (P < 0.01, OR = 3, 4.9) as a risk effect. No significant association was found with MAOA alleles. Among DAT1 polymorphisms two alleles (7 and 11 repeats) (P < 0.01, OR = 2.5 and 3.3) as well as two genotypes (11/11 and 11/7) (P < 0.01, OR = 4, 3) showed significant association with ADHD as a risk effect. On the contrary, 9 and 10 repeats revealed significant association as a protective effect as well as 10/10 and 10/9 genotypes. These findings support the hypothesis that some of the MAOA and DAT1 polymorphisms have a causative role in the development of ADHD in the Saudi population. Another polymorphism did not give rise to support this hypothesis. This is the first report investigated the association between MAOA and DAT1 polymorphism at molecular level in Saudi Arabia population as well as Arab world. Therefore further studies are needed to generalize obtained results at Saudi Arabia.

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Association of Adult Attention Deficit Hyperactivity Disorder With Dopamine Transporter Gene, Dopamine D3 Receptor, and Dopamine D4 Receptor Gene Polymorphisms

Cited by 6 publications

References 34 publications

Candidate Gene Studies of Attention Deficit Hyperactivity Disorder

Candidate Gene Studies of Attention Deficit Hyperactivity Disorder

Analysis of Association Between the Effects of Methylphenidate and DRD4 Gene Polymorphisms in Patients with Attention Deficit Hyperactivity Disorder

Association study between the dopamine-related candidate gene polymorphisms and ADHD among Saudi Arabia population via PCR technique

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