Association of Acromegaly and Chondrosarcoma

Re, Ratner; Jw, Hare

doi:10.1097/00007611-198309000-00034

Cited by 9 publications

(6 citation statements)

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“…Accelerated growth of osteogenic sarcoma was found in patients with elevated levels of GH and somatomedins (Ward et al 1987). In addition, their have been reports of increased GH concentrations associated with bone cancer (Ratner and Hare 1983) and multiple myeloma (Haegg and Asplun 1988). Human neoplastic lung tissue, freshly obtained at surgery, contained more IGF-I than did the corresponding normal tissue (Minuto et al 1986).…”

Section: Discussionmentioning

confidence: 99%

Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells

Lincoln

Sinowatz

Temmim-Baker

et al. 1998

Histochemistry and Cell Biology

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Growth hormone (GH) exerts its regulatory functions in controlling metabolism, balanced growth and differentiated cell expression by acting on specific receptors which trigger a phosphorylation cascade, resulting in the modulation of numerous signalling pathways dictating gene expression. A panel of five monoclonal antibodies was used in mapping the presence and somatic distribution of the GH receptor by immunohistochemistry in normal and neoplastic tissues and cultured cells of human, rat and rabbit origin. A wide distribution of the receptor was observed in many cell types. Not all cells expressing cytoplasmic GH receptors displayed nuclear immunoreactivity. In general, the relative proportion of positive cells and intensity of staining was higher in neoplastic cells than in normal tissue cells. Immunoreactivity showed subcellular localisation of the GH receptor in cell membranes and was predominantly cytoplasmic, but strong nuclear immunoreaction was also apparent in many instances. Intense immunoreactivity was also observed in the cellular Golgi area of established cell lines and cultured tissue-derived cells in exponential growth phase, indicating cells are capable of GH receptor synthesis. The presence of intracellular GH receptor, previously documented in normal tissues of mostly animal origin, is the result of endoplasmic reticulum and Golgi localisation. Heterogeneity of immunoreactivity was found in normal and neoplastic tissue with a variable range of positive cells. The nuclear localisation of immunoreactivity is the result of nuclear GH receptor/binding protein, identically to the cytosolic and plasma GH-binding protein, using a panel of five monoclonal antibodies against the GH receptor extracellular region. The expression of GH receptors, not only on small proliferating tumour cells such as lymphocytes, but also on well differentiated cells including keratinocytes, suggests that GH is necessary not only for differentiation of progenitor cells, but also for their subsequent clonal expansion, differentiation and maintenance.

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Section: Discussionmentioning

confidence: 99%

Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells

Lincoln

Sinowatz

Temmim-Baker

et al. 1998

Histochemistry and Cell Biology

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“…An increased incidence of benign and malignant neoplasias has been detected in individuals with acromegaly 20,21,23,24,31. A role for GH in neoplastic dissemination has also been suggested, since it was observed that patients with prostate cancer who developed metastases had higher serum concentrations of GH than patients without metastases 25.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, recombinant GH should be used with caution when treating short stature NF1 children, especially those who have plexiform neurofibroma. It is important to emphasize that plexiform neurofibroma is the most common precursor of MPNST, which has a very poor prognosis, and previous studies have suggested that GH may influence the development of other malignant neoplasms 2,5,6,21,22,25,26,27,28,29,31,32…”

Section: Discussionmentioning

confidence: 99%

Identification of Growth Hormone Receptor in Plexiform Neurofibromas of Patients with Neurofibromatosis Type 1

Cunha

Barboza

Fonseca

2008

Clinics

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OBJECTIVE: The aim of this study was to investigate the presence of growth hormone receptor in plexiform neurofibromas of neurofibromatosis type 1 patients. INTRODUCTION: The development of multiple neurofibromas is one of the major features of neurofibromatosis type 1. Since neurofibromas commonly grow during periods of hormonal change, especially during puberty and pregnancy, it has been suggested that hormones may influence neurofibromatosis type 1 neurofibromas. A recent study showed that the majority of localized neurofibromas from neurofibromatosis type 1 patients have growth hormone receptor. METHODS: Growth hormone receptor expression was investigated in 5 plexiform neurofibromas using immunohistochemistry. RESULTS: Four of the 5 plexiform neurofibromas were immunopositive for growth hormone receptor. CONCLUSION: This study suggests that growth hormone may influence the development of plexiform neurofibromas in patients with neurofibromatosis type 1

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“…In addition, studies have detected an increase in the incidence of benign and malignant tumours in individuals with acromegaly. [24][25][26][27] There have also been reports of an increased incidence of leukaemia in individuals treated with recombinant GH. 28 29 Using immunohistochemistry, Lincoln et al reported that the ratio of immunopositive cells for GHR was higher in tumours than in normal tissues.…”

Section: Discussionmentioning

confidence: 99%

Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1

Cunha

2003

Journal of Clinical Pathology

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Association of Acromegaly and Chondrosarcoma

Cited by 9 publications

References 0 publications

Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells

Growth hormone receptor expression in the nucleus and cytoplasm of normal and neoplastic cells

Identification of Growth Hormone Receptor in Plexiform Neurofibromas of Patients with Neurofibromatosis Type 1

Identification of growth hormone receptor in localised neurofibromas of patients with neurofibromatosis type 1

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