Association of ABO blood groups with SARS-COV-2 infection

Abstract

In view of the influence of ABO blood group antigens on infectious diseases, we explore the effect of ABO blood types on SARS-COV-2 infection. In this report, demographic data of 80 COVID-19 patients and 26 SARS-COV-2 asymptomatic carriers were collected based on electronic medical records. The results indicated that the distribution of ABO blood group in the confirmed patients was significantly different from asymptomatic carriers; importantly, antigen A carrier have significantly higher risk of developing into severe or critically cases than other types. These data present further evidence for the association of the blood groups to susceptibility to SARS-COV-2 infection.

ABO Blood Group is Associated with COVID-19 Susceptibility: a Systematic Review and Meta-Analysis

“…One study that met inclusion criteria for qualitative synthesis was later dropped for meta-analysis due to low quality (quality score of 3) as seen in Table 1 and data on ABO blood group and COVID-19 were not clearly extractable [19]. Finally, a total of 14 [20][21][22][23][24][25][26][27][28][29][30][31][32][33] studies were included in this systematic review and meta-analysis.…”

“…The random-effect model was used to obtain the pooled odds ratios (ORs) and 95% confidence interval (CIs) and was used to measure the association between SARS-COV-2 infection, COVID-19 severity, COVID-19 related deaths and ABO [33] in one ( 1) manuscript presented three (3) studies in 3 different areas in China and presented differently here. Also, all control participants are COVID-19 negative subjects apart from those reported by Zhou et al [21] which are asymptomatic carriers.…”

“…The studies were all published in year 2020 (Table 2). On study location, six of the studies were carried out in China [21,23,28,30,31,33], four in US [24][25][26]32], one each in France [22], Turkey [29] and Iran [20]. One of the studies was multi-country in nature (involving Spain and Italy) [27].…”

“…while in one [22], and in four other studies [23][24][25]28] control data were obtained from populations with same level of exposure and hospitalized patients who were in admission before COVID-19 episode, respectively. Control data was obtained from asymptomatic COVID-19 carriers in one study [21] while two studies [26,31] did not use control.…”

“…The ABO blood group has been linked to diseases such as Norovirus [15], Influenza [16], Plasmodium falciparum infection and cancer [17]. Now there are growing evidences that showed the susceptibility to SARS-COV-2 is related to the ABO blood group of an individual [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Also, conflicting evidences exist on the relationship between ABO blood group and the severity and clinical outcome of COVID-19 disease.…”