Association of ABO blood group with P‐selectin levels in Chinese Han healthy volunteers

Chen, Ying; Zhuo, Xiaofu; Lin, Yi‐Sheng; Huang, Wenhua; Xiao, Jing; Zeng, Jia; Jiang, Li; Chen, Cen; Lin, Haijuan; Dettke, Markus

doi:10.1111/trf.13212

Cited by 8 publications

(12 citation statements)

References 36 publications

(73 reference statements)

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“…Similarly, Chen et al 46 also identified lower serum (but not platelet) P-selectin levels in Han Chinese, a population in which the A2 allele is not present. In MESA, HIS, EUR, and CHN participants all demonstrated a mean decrease of approximately 19% per A1 allele, in contrast to AFA, which only corresponded to a mean decrease of 9.5%.…”

Section: Discussionmentioning

confidence: 80%

ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

et al. 2016

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Background and aims ABO blood type is associated with cardiovascular disease, although the underlying mechanisms are presumed to be complex. While the relationship between non-O blood types and von Willebrand Factor (vWF) is well-established, associations with cellular adhesion molecules (CAMs) across diverse populations are understudied. Methods We genetically inferred ABO alleles for N=6202 participants from the Multi-Ethnic Study of Atherosclerosis. Linear regression was used to evaluate associations between major ABO allele dosages and log-transformed measurements of vWF (N=924), soluble E-selectin (sE-selectin, N=925), soluble P-selectin (sP-selectin, N=2392), and soluble ICAM-1 (sICAM-1, N=2236) by race/ethnicity. Results For the selectins, the A1 allele was associated with significantly lower levels for all races/ethnicities, with each additional allele resulting in a 28-39% decrease in sE-selectin and 10-18% decrease in sP-selectin relative to Type O subjects. However, the A2 allele demonstrated effect heterogeneity across race/ethnicity for sE-selectin, with lower levels for non-Hispanic whites (p=0.0011) but higher levels for Hispanics (p=0.0021). We also identified elevated sP-selectin levels for B-allele carriers solely in Hispanic participants (p=1.0E-04). ABO-by-race/ethnicity interactions were significant for both selectins (p <0.0125). More modest associations were observed between A1 allele dosage and levels of sICAM-1, with ABO alleles explaining 0.8-1.1% of the total phenotypic variation within race/ethnicity. ABO associations with vWF activity were consistent across race/ethnicity, with B allele carriers corresponding to the highest vWF activity levels. Conclusions ABO blood type demonstrates complex associations with endothelial markers that are largely generalizable across diverse populations.

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Section: Discussionmentioning

confidence: 80%

ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

et al. 2016

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“…ABO blood group constitute ABH-antigens which are complex carbohydrate molecules (glycoprotein and glycolipids) expressed on the extracellular surfaces of human cells and tissues, including red cell membrane, platelets, and vascular endothelial cell [1][2][3]. ABO blood group has been recognized as an essential system in clinical practice particularly in the field of transfusion and transplantation medicine [4]. Since its discovery, ABO group has been studied as etiological factors of many diseases [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Considerable evidence underpins CVDs to be linked with ABO blood group system [3,4,23,45] although the mechanism linking ABO blood group with CVD, particularly atherosclerosis, remains unclear. However, previous studies suggest that ABH antigen act as the principal agent for endothelial cell proliferation [3], as such plays a role in the disease process by a modulation in the vascular endothelial haemostasis [1,30].…”

Section: Introductionmentioning

confidence: 99%

Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study

Ureme

Anioke

Igboerika

2018

AJRB

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Objective: The study investigated the possibility of using blood groups as predictive indices for diseases associated with lipid metabolism. Methods: Lipid profiles were examined in 100 apparently healthy male (40) and female (60) subjects of different ABO blood groups aged between 18-30 years from Imo State University. Of these, 20 were blood group A, 30 were B blood type, 4 were AB blood type, and 46 were blood group O. Lipid profile parameters were determined according to enzymatic assay using a commercial kit from Randox Laboratories, United Kingdom and calculation using Friedewald’s equation. Monoclonal ABO blood grouping reagent by CLAS Technology, United Kingdom was used to determine the blood group. Results: Total Cholesterol (140.62 ± 21.66 mg/dl) and High-Density Lipoprotein (HDL) (96.20 ± 40.32 mg/dl) were highest in blood group B. Blood group A had the highest level of Triglyceride (80.84 ± 18.60 mg/dl) and Very Low-Density Lipoprotein (VLDL) (15.21 ± 6.24 mg/dl). Blood group O showed TC level of 130.60 ±34.76 mg/dl with the highest level of LDL (70.74 ± 20.15 mg/dl) and the lowest level of HDL (51.68 ± 20.50 mg/dl) compared to non- O blood types (P < 0.05). Conclusion: The study revealed that blood group O might have a higher propensity for dyslipidemia, suggesting an increased risk for disease associated with lipid metabolism.

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“…Moreover, in AFA (P = 3.4E-06), we observed evidence of increased levels of RANTES and TGFβ-1, while HIS participants exhibited increased circulation of SLPI. These results, like others(Chen et al 2015; Kiechl et al 2011), seemingly contradict the hypothesis that sP-selectin may mediate the association between ABO blood type and atherosclerotic CVD, as increased sP-selectin has been shown to correlated with higher CVD risk(Ridker et al 2001). However, potential explanations have been proffered that accommodate this apparently paradoxical relationship(Kiechl et al 2011).…”

Section: Discussionmentioning

confidence: 60%

“…This glycoprotein is recognized to be directly modified by ABO glycosyltransferases, and Type O subjects have been shown to be at reduced risk for venous thromboembolism(Ohira et al 2007; Sode et al 2013; Wiggins et al 2009; Zakai et al 2014). Recent GWASs(Barbalic et al 2010; Chen et al 2015; Kiechl et al 2011) have also identified multiple ABO SNP associations with circulating levels of a number of markers of endothelial function, including sP-selectin and sICAM-1. Mechanistically, it has been suggested that ABO glycosyltransferases may regulate endothelial markers through cleavage or proteolysis, since ABO associations with sP-selectin have not been replicated for platelet-bound levels(Barbalic et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis

et al. 2016

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The cellular adhesion pathway is critical in the pathophysiology of atherosclerosis, and genetic factors contributing to regulation of circulating levels of related proteins may be relevant to risk prediction of cardiovascular disease. In contrast to conducting separate genome-wide protein quantitative trait loci (pQTL) mapping analyses of each individual protein, joint genetic association analyses of multiple quantitative traits can leverage cross-trait co-variation and identify simultaneous regulatory effects on protein levels across the pathway. We conducted a multi-pQTL (mpQTL) analysis of 15 proteins related to cellular adhesion assayed on 2,313 participants from the Multi-Ethnic Study of Atherosclerosis (MESA). We applied the MQFAM multivariate association analysis method in PLINK on normalized protein level residuals derived from univariate linear regression, adjusting for age, sex, and principal components of ancestry. Race/ethnicity-stratified analyses identified nine genome-wide significant (P<5e-08) loci associated with co-variation of protein levels. Although the majority of these SNPs were in proximity to structural genes of the assayed proteins, we discovered multiple loci demonstrating co-association with the circulation of at least two proteins. Of these, two significant loci specific to non-Hispanic white participants, rs17074898 at ALOX5AP (P = 1.78E-08) and rs7521237 at KIAA1614 (P = 2.2E-08), would not have met statistical significance using univariate analyses. Moreover, common patterns of multi-protein associations were discovered at the ABO locus across race/ethnicity. These results indicate the biological relevance of blood group antigens on regulation of circulating cellular adhesion pathway proteins while also demonstrating race/ethnicity-specific co-regulatory effects.

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Association of ABO blood group with P‐selectin levels in Chinese Han healthy volunteers

Abstract: This study demonstrated an association between sP-selectin levels and ABO groups in a Chinese Han population, implicating its generalizability to other ethnic groups. This finding will improve the understanding of the mechanism of ABO blood group-associated diseases.

Cited by 8 publications

References 36 publications

ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study

Blood group antigen loci demonstrate multivariate genetic associations with circulating cellular adhesion protein levels in the Multi-Ethnic Study of Atherosclerosis

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