ABO blood group associations with markers of endothelial dysfunction in the Multi-Ethnic Study of Atherosclerosis

Abstract

Background and aims ABO blood type is associated with cardiovascular disease, although the underlying mechanisms are presumed to be complex. While the relationship between non-O blood types and von Willebrand Factor (vWF) is well-established, associations with cellular adhesion molecules (CAMs) across diverse populations are understudied. Methods We genetically inferred ABO alleles for N=6202 participants from the Multi-Ethnic Study of Atherosclerosis. Linear regression was used to evaluate associations between major ABO allele dosages and log-transformed measurements of vWF (N=924), soluble E-selectin (sE-selectin, N=925), soluble P-selectin (sP-selectin, N=2392), and soluble ICAM-1 (sICAM-1, N=2236) by race/ethnicity. Results For the selectins, the A1 allele was associated with significantly lower levels for all races/ethnicities, with each additional allele resulting in a 28-39% decrease in sE-selectin and 10-18% decrease in sP-selectin relative to Type O subjects. However, the A2 allele demonstrated effect heterogeneity across race/ethnicity for sE-selectin, with lower levels for non-Hispanic whites (p=0.0011) but higher levels for Hispanics (p=0.0021). We also identified elevated sP-selectin levels for B-allele carriers solely in Hispanic participants (p=1.0E-04). ABO-by-race/ethnicity interactions were significant for both selectins (p <0.0125). More modest associations were observed between A1 allele dosage and levels of sICAM-1, with ABO alleles explaining 0.8-1.1% of the total phenotypic variation within race/ethnicity. ABO associations with vWF activity were consistent across race/ethnicity, with B allele carriers corresponding to the highest vWF activity levels. Conclusions ABO blood type demonstrates complex associations with endothelial markers that are largely generalizable across diverse populations.

Lipid Profiles in Different ABO Blood Groups in Owerri Metropolis, South East Nigeria- A Preliminary Study

“…However, previous studies suggest that ABH antigen act as the principal agent for endothelial cell proliferation [3], as such plays a role in the disease process by a modulation in the vascular endothelial haemostasis [1,30]. Besides, the theory that glycosyltransferases (enzymes involved in the modification of the A, B and H antigens) regulate circulation of soluble products of cellular adhesion molecules (CAMs)biomarkers of inflammation-related diseasesmay explain the relationship [4,31]. Previous evidence has reported increase in the biomarkers to be associated with cardiovascular diseases (CVDs) [32][33][34][35][36].…”

Genome-wide Association Study Of Plasma Proteins Identifies Putatively Causal Genes, Proteins, And Pathways For Cardiovascular Disease

“…ABO blood type has long been linked to CVD risk, including in the FHS, 26 additional reports have linked the ABO locus to CVD via coagulation pathways. 27,28 ABO locus-related proteins, identified in our study, are involved in inflammatory pathways, including interleukin and interferon signaling ( Figure 2). The multi-protein association of this locus may be driven by the general function of ABO as a glycosyltransferase.…”

Soluble vascular cell adhesion molecular-1 is a potential biological indicator of hemophilic arthropathy

“…[18,20,21] No patients in this study had coronary artery disease, myocardial infarction, or atherosclerosis. Three patients aged 38.72, 46.81, and 46.00 years had hypertension.…”

“…[21,25] To clarify whether the expression of these cell surface adhesion molecules are affected by ABO blood group, the association between ABO blood group and these cell surface adhesion molecules levels was analyzed. In 27 patients with hemophilia A, whose ABO blood type were obtained through medical record review, sVCAM-1, sE-Selectin, and sP-selectin levels did not differ significantly among ABO blood groups ( P  > 0.05).…”