Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality

Ishaq, Uzma; Malik, Asmara; Malik, Jahanzeb; Mehmood, Asad; Qureshi, Azhar Munir; Laique, Talha; Smj, Zaidi; Javaid, Muhammad; As, Rana

doi:10.1101/2021.04.19.21255738

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…Furthermore, emerging studies have shown that ABO blood groups may also play a major role in the course of illness and in the outcome of COVID-19 patients; for example, COVID-19 was found to be less prevalent among people with blood group O. On the other hand, people with blood group A were more susceptible to acquiring COVID-19 with a higher mortality rate [9][10][11]. We used a well-crafted data sheet composed of five main sections: demographics, clinical features, vital signs, laboratory findings, and COVID-19 outcomes.…”

Section: Introductionmentioning

confidence: 99%

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Bokhary¹,

Bokhary²,

Seadawi³

et al. 2022

Cureus

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The primary objective of this study was to explore whether coronavirus disease 2019 severity and outcomes varied between different ABO blood groups. This retrospective study included 363 COVID-19 confirmed patients who had their blood group recorded in the hospital medical records, from March to June 2020. Data representing demographics, clinical features, vital signs, laboratory findings, and COVID-19 outcomes were collected. Multivariate logistic regression was used for analysis and the results were adjusted for sociodemographic, clinical, and laboratory variables. The patients' mean age was 50 ± 17.8 years. Of the 363 patients, 30% were blood group A, 22.3% were blood group B, 8.8% were blood group AB, and 38.8% were blood group O. Bivariate analysis showed that patients with blood group AB were more likely to be free of any medical disease (65.6%) compared to other blood groups (p = 0.007). Fever was the most common presenting complaint (66.7%), and it did not significantly vary with changes in ABO blood groups (p = 0.230). Regarding laboratory characteristics, only C-reactive protein (CRP) levels were significantly associated with the blood groups, with high levels seen in blood groups A, B, and O (p = 0.036). In multivariate analysis, variations in emergency department (ED) disposition, requirement of intensive care unit care, and requirement of mechanical ventilation were not statistically significant among the different ABO blood groups. Furthermore, no correlation was found between hospital death and the different ABO blood groups. In conclusion, COVID-19 is most prevalent among patients with blood group O and least prevalent among those with blood group AB. No particular blood group had worse COVID-19 disease severity and outcomes than other blood groups. Therefore, we believe that ABO blood grouping should not be used as a major assessment tool for COVID-19 disease severity and outcome, and other known risk factors should be investigated.

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Section: Introductionmentioning

confidence: 99%

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Bokhary¹,

Bokhary²,

Seadawi³

et al. 2022

Cureus

View full text Add to dashboard Cite

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Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

et al. 2021

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Aim: Many factors have been speculated to explain the COVID-19 complex clinical phenotype. Due to the inconsistent data published on blood groups and COVID-19, we conducted a study on Iranian patients to further assess this association. Materials & methods: This retrospective study was conducted on data collected from confirmed COVID-19 hospitalized patients during March and December 2020 in a referral hospital for COVID-19, 5 Azar Hospital, Gorgan, north of Iran. A total of 1554 confirmed COVID-19 cases were enrolled in the study with blood group (ABO and Rh), demographic, and clinical data available. Results: Of 1554 patients, 1267 and 287 cases had recovered and deceased (due to COVID-19) outcomes, respectively. Most of the cases had O+ (29.6%), the least number had AB- (0.5%), and most of the deceased cases had O+ blood types (31.4%). Logistic regression analysis revealed that groups A- and B- had higher and groups B+, AB+, O+ and O- had lower odds of death than the A+ group. Conclusion: This study indicates that blood types may be related to the clinical outcome of COVID-19. Further studies with a large cohort for multiple people are required to validate this association.

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A Clinical Qualification Protocol Highlights Overlapping Genomic Influences and Neuro-Autonomic Mechanisms in Ehlers–Danlos and Long COVID-19 Syndromes

Wilson

2023

CIMB

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A substantial fraction of the 15% with double-jointedness or hypermobility have the traditionally ascertained joint-skeletal, cutaneous, and cardiovascular symptoms of connective tissue dysplasia and its particular manifestation as Ehlers–Danlos syndrome (EDS). The holistic ascertainment of 120 findings in 1261 EDS patients added neuro-autonomic symptoms like headaches, muscle weakness, brain fog, chronic fatigue, dyspnea, and bowel irregularity to those of arthralgia and skin laxity, 15 of these symptoms shared with those of post-infectious SARS-CoV-2 (long COVID-19). Underlying articulo-autonomic mechanisms guided a clinical qualification protocol that qualified DNA variants in 317 genes as having diagnostic utility for EDS, six of them identical (F2-LIFR-NLRP3-STAT1-T1CAM1-TNFRSF13B) and eighteen similar to those modifying COVID-19 severity/EDS, including ADAMTS13/ADAMTS2-C3/C1R-IKBKG/IKBKAP-PIK3C3/PIK3R1-POLD4/POLG-TMPRSS2/TMPRSS6-WNT3/WNT10A. Also, contributing to EDS and COVID-19 severity were forty and three genes, respectively, impacting mitochondrial functions as well as parts of an overlapping gene network, or entome, that are hypothesized to mediate the cognitive–behavioral, neuro-autonomic, and immune-inflammatory alterations of connective tissue in these conditions. The further characterization of long COVID-19 natural history and genetic predisposition will be necessary before these parallels to EDS can be carefully delineated and translated into therapies.

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Association of ABO blood group with COVID-19 severity, acute phase reactants and mortality

Cited by 6 publications

References 15 publications

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Variation in COVID-19 Disease Severity and Clinical Outcomes Between Different ABO Blood Groups

Association Between Blood Groups and COVID-19 Outcome in Iranian Patients

A Clinical Qualification Protocol Highlights Overlapping Genomic Influences and Neuro-Autonomic Mechanisms in Ehlers–Danlos and Long COVID-19 Syndromes

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