Association of a potential functional mir-520f rs75598818 G &gt; A polymorphism with breast cancer

Meshkat, Marzieh; Tanha, Hamzeh Mesrian; Ghaedi, Kamran; Meshkat, Mahboobeh

doi:10.1007/s12041-018-1028-3

Cited by 7 publications

(11 citation statements)

References 26 publications

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“…Presently, miR‐520f‐3p was expressed in low levels in glioma tissues and cells, and inhibited the malignant biological behavior of glioma cells. Similarly, miR‐520f‐3p is regarded as a potential tumor suppressor in breast cancer . MicroRNAs usually bind to the 3′UTR region of target gene mRNA to inhibit its translation.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, miR-520f-3p is regarded as a potential tumor suppressor in breast cancer. 25 MicroRNAs usually bind to the 3′UTR region of target gene mRNA to inhibit its translation. In this study, a dual luciferase reporter system gene assay indicated that miR-520f-3p bound to the 3′UTR region of TFAP4 mRNA.…”

Section: Discussionmentioning

confidence: 99%

“…As examples, miR‐217 is underexpressed in glioma tissues and cells, miR‐4286 inhibits proliferation and migration of nonsmall‐cell carcinoma cells, and miR‐494 reduces the activity of CASP2 and inhibits the proliferation of nonsmall‐cell lung cancer . A study implicated miR‐520f‐3p as a potential tumor suppressor for breast cancer . However, the influence and mechanism of miR‐520f‐3p on the malignant biological behaviors of glioma cells are unknown.…”

Section: Introductionmentioning

confidence: 99%

“…24 A study implicated miR-520f-3p as a potential tumor suppressor for breast cancer. 25 However, the influence and mechanism of miR-520f-3p on the malignant biological behaviors of glioma cells are unknown.…”

Section: Introductionmentioning

confidence: 99%

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Transcription factor AP‐4 (TFAP4)‐upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA‐520f‐3p feedback loop

et al. 2020

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Upstream ORF (uORF) is a translational initiation element located in the 5′UTR of eukaryotic mRNAs. Studies have found that uORFs play an important regulatory role in many diseases. Based on The Cancer Genome Atlas database, the results of our experiments and previous research evidence, we investigated transcription factor AP‐4 (TFAP4) and its uORF, LIM and SH3 protein 1 (LASP1), long noncoding RNA 00520 (LINC00520), and microRNA (miR)‐520f‐3p as candidates involved in glioma malignancy, which is a poorly understood process. Both TFAP4‐66aa‐uORF and miR‐520f‐3p were downregulated, and TFAP4, LASP1, and LINC00520 were highly expressed in glioma tissues and cells. TFAP4‐66aa‐uORF or miR‐520f‐3p overexpression or TFAP4, LASP1, or LINC00520 knockdown inhibited glioma cell proliferation, migration, and invasion, but promoted apoptosis. TFAP4‐66aa‐uORF inhibited the translation of TFAP4 by binding to the TFAP4 mRNA. MicroRNA‐520f‐3p inhibited TFAP4 expression by binding to its 3′UTR. However, LINC00520 could promote the expression of TFAP4 by competitively binding to miR‐520f‐3p. In addition, TFAP4 transcriptionally activated LASP1 and LINC00520 expression by binding to their promoter regions, forming a positive feedback loop of TFAP4/LINC00520/miR‐520f‐3p. Our findings together indicated that TFAP4‐66aa‐uORF inhibited the TFAP4/LINC00520/miR‐520f‐3p feedback loop by directly inhibiting TFAP4 expression, subsequently leading to inhibition of glioma malignancy. This provides a basis for developing new therapeutic approaches for glioma treatment.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Transcription factor AP‐4 (TFAP4)‐upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA‐520f‐3p feedback loop

et al. 2020

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“…In our study, we predicted the target miRNAs of circ_0043278 by bioinformatics analysis and verified circ_0043278/miR-520f axis could regulate ROCK1, CDKN1B, and AKT3 expression in NSCLC that gives strength as a evidence for the ceRNA regulation theory. In addition, we also investigated the role of miR-520f in NSCLC, which has been reported to be a famous tumor suppressor in gastric cancer, breast cancer, and hepatocellular carcinoma [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f

Cui

Liu

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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More and more circular RNAs (circRNAs) revealed to play a critical role in the initiation and progression of cancer, however, the effects of circRNAs on non-small cell lung cancer (NSCLC) remain largely undetermined. In the present study, we screened the dysregulated circRNAs in paired NSCLC and normal samples from GEO database and identified circ_0043278 was to be significantly up-regulated in NSCLC and demonstrated it promotes NSCLC progression in vitro and in vivo. Then, we revealed the expression of miR-520f, a downstream factor of circ_0043278, was significantly down-regulated in NSCLC and acted as a tumor inhibitor. In addition, we revealed that circ_0043278 sponged miR-520f, which was demonstrated to target ROCK1, CDKN1B, and AKT3 in NSCLC cells. In conclusion, circ_0043278 promoted NSCLC cell proliferation, invasion, and migration by increasing ROCK1, CDKN1B, and AKT3 expressions through direct inhibition of miR-520f.

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A genetic variant of pri‐miR‐182 may impact the risk for the onset of multiple sclerosis in the Iranian population

Najafi

Peymani

2020

American J Hum Biol

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Background: Multiple sclerosis (MS) is the most common autoimmune disease of the central nervous system affecting young adults. SNPs can be used as genetic biomarkers to identify disease-related genes such as MS. Moreover, SNPs can be considered as important determinants for an increased risk of autoimmune diseases such as MS. Studies have shown that miR-182 is of importance in Treg cell development and function as critical regulators in autoimmune disease. So far, no study has been conducted to investigate the association between rs4541843 polymorphism in pri-miR-182 and MS. In the present study, we assessed the frequency of rs4541843 different alleles and genotypes and their association with MS risk in Iranian population. Methods: The rs4541843 was genotyped in 81 patients with MS and 89 healthy subjects, using the PCR-RFLP method. The frequency of alleles and genotypes and the association of this polymorphism with MS risk and the gender of the patients was then statistically analyzed. Results: Statistical analysis showed the protective role of AA genotype against MS risk (P = .031, OR = 0.348) while there was no significance correlation between the frequency of rs4541843 different alleles and the other genotypes. Conclusion: Our findings illustrated that the pri-miR-182 rs4541843 G>A polymorphism is associated with the risk of MS in Isfahan population. However, additional large-scale association studies in various ethnicities and more molecular studies are necessary to elaborate our findings.

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Association of a potential functional mir-520f rs75598818 G > A polymorphism with breast cancer

Cited by 7 publications

References 26 publications

Transcription factor AP‐4 (TFAP4)‐upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA‐520f‐3p feedback loop

Transcription factor AP‐4 (TFAP4)‐upstream ORF coding 66 aa inhibits the malignant behaviors of glioma cells by suppressing the TFAP4/long noncoding RNA 00520/microRNA‐520f‐3p feedback loop

A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f

A genetic variant of pri‐miR‐182 may impact the risk for the onset of multiple sclerosis in the Iranian population

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