Association of a Nonsynonymous Variant of DAOA with Visuospatial Ability in a Bipolar Family Sample

Soronen, Pia; Silander, Kaisa; Antila, M.; Palo, Outi M.; Tuulio‐Henriksson, Annamari; Kieseppä, Tuula; Ellonen, Pekka; Wedenoja, Juho; Turunen, Joni A.; Pietiläinen, Olli; Hennah, William; Lönnqvist, Jouko; Peltonen, Leena; Partonen, Timo; Paunio, Tiina

doi:10.1016/j.biopsych.2008.03.028

Cited by 18 publications

(15 citation statements)

References 21 publications

(34 reference statements)

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“…Additional evidence supports the involvement of DAOA/G30 and DAO in the etiology of bipolar disorder, but none indicated any interaction between these genes 30 . DAOA thus may play an important role in the predisposition of individuals with a mixed phenotype of psychosis and mania and lead to changes in the expressed characteristics of these psychological illnesses 31 . Williams et al 32 suggested that depression is associated with greater glutamatergic function.…”

Section: Discussionmentioning

confidence: 99%

“…An analysis of these articles associated identified five genes as the most cited in the literature: CANAC1C [16][17][18][19][20][21][22][23][24] , DAOA [25][26][27][28][29][30][31][32] 22 . Some articles related the genetic polymorphism specifying the classification of TBI 8,25,27,32,35,36,39,41 , in addition to TBI and II 37 .…”

Section: Genes and Polymorphisms Associated With Demonstrationmentioning

confidence: 99%

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Associação entre polimorfismos genéticos e transtorno bipolar

Alves¹,

Silva²,

Neto³

et al. 2012

Rev. psiquiatr. clín.

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Bipolar disorder (BD) is a common disorder that affects approximately 1% of the population. It is associated with both chronic and acute severe features, such as low remission rates and a high prevalence of clinical and psychiatric comorbidities. The aim of the present article is to synthesize data from various articles that investigated genetic polymorphisms associated with BD. The 129 articles selected identified 79 (85.87%) genes associated with BD. This analysis identified the five genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identified in these articles, 33 (35.87%) showed no association with BD. This analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Keywords: Bipolar disorder, genes, polymorphisms, heredity, gene ontology, association with bipolar disorder. ResumoTranstorno bipolar (TB) é uma doença comum que afeta aproximadamente 1% da população. Apresenta características crônicas e agudas graves, com índices de remissão de baixa e alta prevalência de comorbidades clínicas e psiquiátricas. O objetivo do presente artigo é sintetizar dados de vários artigos que investigaram polimorfismos genéticos associados com TB. Dentre os 129 artigos selecionados, identificaram-se 79 (85,87%) genes associados com TB. Essa análise identificou cinco genes que são os mais citados na literatura: CANAC1C, DAOA, TPH2, ANK3 e DISC1. Dos 92 genes identificados nesses artigos, 33 (35,87%) não mostraram associação com TB. Essa análise mostrou que, apesar dos avanços recentes com relação ao papel do polimorfismo genético na predisposição para TB, mais pesquisas ainda são necessárias para elucidar sua influência sobre esse transtorno.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Palavras-chave: Transtorno bipolar, genes, polimorfismos, hereditariedade, ontologia genética, associação com transtorno bipolar.

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Section: Discussionmentioning

confidence: 99%

Section: Genes and Polymorphisms Associated With Demonstrationmentioning

confidence: 99%

Associação entre polimorfismos genéticos e transtorno bipolar

Alves¹,

Silva²,

Neto³

et al. 2012

Rev. psiquiatr. clín.

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“…Schizophrenia and bipolar mood disorders affect many families simultaneously. This theme suggests that these disorders have a shared genetic etiology at least to some extent [29]. Traditionally, search for predisposing genes, has proceeded under the presumption that schizophrenia and bipolar disorder are segregate disease entities.…”

Section: Discussionmentioning

confidence: 99%

Genetic Overlap Between Affective Disorders: An Association Analysis of M18 and M23 SNPs of DAOA/G72 Gene With Schizophrenia and Bipolar Disorder

Ahmadi

Kazeminezhad

Khajehdin

et al. 2015

Zahedan J Res Med Sci

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Background: Schizophrenia and bipolar disorder are common and often destructive brain disorders. It has generally been assumed that dozens of genes, along with environmental factors, contribute to the development of these diseases. Schizophrenia and bipolar mood disorder affect many families simultaneously. This theme suggests that these disorders have a shared genetic etiology at least to some extent. The DAOA/G72 gene is one of the common loci shared both by schizophrenia and bipolar disorder. The functions of this gene could converge in a pathway of glutamate metabolism. Objectives: The purpose of the study was determination of genetic overlap between affective disorders using association analysis of M18 and M23 SNPs of DAOA/G72 gene with schizophrenia and bipolar disorder. Patients and Methods:In this case-control study, in order to evaluate the potential association of DAOA gene with schizophrenia and bipolar disorder in a southwest Iran population, two single nucleotide polymorphisms M18 and M23 were genotyped by the PCR-RFLP method and sequencing assay in 127 normal controls and 100 patients with schizophrenia and 100 patients with bipolar disorder. Data were analyzed by Logistic Regression and Mantel-Haenszel chi square tests. Results: Our finding showed that the M18 was significantly associated with bipolar disorder. We observed there is overlap association in M23 with schizophrenia and bipolar disorder. Also, our results indicated that the coexistence of the A and T alleles from the two polymorphisms, M18 and M23, increase the risk for schizophrenia and bipolar disorder. Conclusions: In summary, our data provides further evidence for a positive association between the DAOA locus and schizophrenia and bipolar disorder, these results may provide further support for genetic overlap in DAOA gene between schizophrenia and bipolar disorder.

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“…It causes an arginine-to-lysine substitution at codon 30 (Arg30Lys) and might therefore be of putative functional relevance (Donohoe et al, 2007). Recently, it has been shown that the DAOA rs2391191 SNP variant is associated with a significantly lower visual memory capacity in patients with a psychotic disorder (Soronen et al, 2008). Additionally, the rs2391191 SNP variant is associated with impaired verbal memory in schizophrenia (Donohoe et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

Schultz

Nenadić

Koch

et al. 2011

Neuropsychopharmacol

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In light of current etiological concepts the glutamatergic system plays an essential role for the pathophysiology of the disorder, offering multiple options for new treatment strategies. The D-amino oxidase activator (DAOA) gene is closely connected to the glutamatergic system and its therapeutic and pathophysiological relevance for schizophrenia is therefore intensively debated. In a further step to shed light on the role of DAOA in schizophrenia, we aimed to investigate the association of the functional DAOA Arg30Lys (rs2391191) variant and cortical thickness in schizophrenia. Cortical thickness was computed by an automated surface-based technique (FreeSurfer) in 52 genotyped patients with schizophrenia and 42 healthy controls. Cortical thickness of the entire cortex was compared between risk carriers and non-risk carriers regarding the Arg30Lys polymorphism in patients and healthy controls on the basis of a node-by-node procedure and an automated clustering approach. Risk carriers with schizophrenia show significantly thinner cortex in two almost inversely arranged clusters on the left and right hemisphere comprising middle temporal, inferior parietal, and lateral occipital cortical areas. The clusters encompass an area of 1174 mm 2 (left) and 1156 mm 2 (right). No significant effect was observed in healthy controls. The finding of our study that the Arg30Lys risk variant is associated with a distinct cortical thinning provides new evidence for the pathophysiological impact of DAOA in schizophrenia. The affected areas are mostly confined to cortical regions with a crucial role in the ToM network and visual processing, which both can be influenced by glutamatergic modulation. Our finding thus underlines the importance of DAOA and related glutamatergic processes as a putative target for therapeutic interventions in schizophrenia.

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Association of a Nonsynonymous Variant of DAOA with Visuospatial Ability in a Bipolar Family Sample

Cited by 18 publications

References 21 publications

Associação entre polimorfismos genéticos e transtorno bipolar

Associação entre polimorfismos genéticos e transtorno bipolar

Genetic Overlap Between Affective Disorders: An Association Analysis of M18 and M23 SNPs of DAOA/G72 Gene With Schizophrenia and Bipolar Disorder

Reduced Cortical Thickness is Associated with the Glutamatergic Regulatory Gene Risk Variant DAOA Arg30Lys in Schizophrenia

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