Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population

Palizban, Abbasali; Nikpour, Mahnaz; Salehi, Roya; Maracy, Mohammad Reza

doi:10.1007/s10238-011-0144-7

Cited by 27 publications

(26 citation statements)

References 28 publications

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“…Independent studies have confirmed an association between the TCF7L2 SNPs rs7903146 and/or rs12255372 and T2D in various populations from countries such as England, Finland, Poland, France, Germany, the Netherlands, Sweden, Iran, India, Japan, China, and Tunisia (Cauchi et al, 2006;Groves et al, 2006;Saxena et al, 2006;Scott et al, 2006;Horikoshi et al, 2007;Mayans et al, 2007;van Vliet-Ostaptchouk al., 2007;Ezzidi et al, 2009;Gupta et al, 2010;Wen et al, 2010;Palizban et al, 2012). However, conflicting results have been reported in populations from China, Saudi Arabia, and the United Arab Emirates, as well as in the Native American population of North America (Guo et al, 2007;Alsmadi et al, 2008;Ren et al, 2008;Saadi et al, 2008).…”

Section: Introductionmentioning

confidence: 84%

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

Barros¹,

Araujo-Neto²,

Lopes³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. Approximately 200 million people suffer from type 2 diabetes (T2D) worldwide, and the rapid increase in the prevalence of this disease is likely a result of multiple environmental factors, such as increased food intake and decreased physical activity in genetically predisposed individuals. Different population studies have demonstrated a strong association of two polymorphic variations in the TCF7L2 gene, the noncoding single nucleotide polymorphisms (SNPs) rs7903146 (C/T) and rs12255372 (G/T), with T2D. Herein, we analyzed the association of these SNPs with T2D in a population from northeastern Brazil. Our results showed that the genotype and allele frequencies in TCF7L2 rs7903146 and rs12255372 were similar in the patient and control groups (P > 0.05). In addition, the allele frequencies were not significantly associated with T2D risk [rs7903146: odds ratio (OR) = 0.95, 95% confidence interval (CI) = 0.52-1.76, P = 1.00, and rs12255372: OR = 1.38, 95%CI = 0.72-2.62, P = 0.41]. These data suggest that the TCF7L2 SNPs rs7903146 and rs12255372 may not significantly contribute to T2D susceptibility in this population. However, our results may reflect the small number of subjects. Alternatively, these results may be attributable to specific ethnic effects, as most of the previously reported associations were demonstrated with predominantly European populations. To reach a definitive conclusion on the role of such gene variants for T2D in mixed populations, additional efforts are necessary to replicate this study with larger populations from areas with more ethnic heterogeneity.

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Section: Introductionmentioning

confidence: 84%

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

Barros¹,

Araujo-Neto²,

Lopes³

et al. 2014

Genet. Mol. Res.

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“…Contrary to expectations, many of them conferred only modest effects regarding disease risk and mostly with conflicting results (4,5). The TCF7L2 gene (also known as TCF-4) on chromosome 10q25 has the strongest association with an increased risk of T2DM, and this finding has been well-replicated in multiple populations (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). Reports of strong associations between TCF7L2 gene variants, especially rs7903146 T, and T2DM have been predominantly obtained from European populations.…”

Section: Introductionmentioning

confidence: 98%

Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictorsof type 2 diabetes among nonobese diabetics in the Turkish population

Kaya¹,

Arıkoğlu²,

Kayış³

et al. 2017

Turk J Med Sci

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IntroductionType 2 diabetes mellitus (T2DM) is one of the most challenging health problems of the 21st century. Today more than 371 million people have diabetes globally (1). This figure shows that the number of cases of diabetes is more than expected and has already reached the estimation for the year 2030 (2). Additionally, approximately 50% of people with diabetes are unaware that they have the disease. In 2012, diabetes was responsible for 4.8 million deaths, half of them under the age of 60, and 471 billion USD spent (1). The Turkish population is no exception to this trend. Understanding the mechanisms that contribute to the pathogenesis of T2DM is crucial in implementing rational treatment strategies and to prevent the increasing occurrence of diabetes. T2DM is a polygenic metabolic disorder that can occur in different age groups as a result of the interaction of genetic and environmental factors (3). To determine the genetic basis of T2DM, several genes that were predicted to be T2DM risk factors were studied in numerous populations. Contrary to expectations, many of them conferred only modest effects regarding disease risk and mostly with conflicting results (4,5). The TCF7L2 gene (also known as TCF-4) on chromosome 10q25 has the strongest association with an increased risk of T2DM, and this finding has been well-replicated in multiple populations (6-21). Reports of strong associations between TCF7L2 gene variants, especially rs7903146 T, and T2DM have been predominantly obtained from European populations. However, unlike populations of European origin, in Asian populations, either these variants are unrelated or different variants within the TCF7L2 gene are associated with disease risk (21-25). In Turkey, which is a geographic and cultural bridge between Europe and Asia, a study that investigates the association between TCF7L2 polymorphisms and T2DM is lacking. In this study, we aimed to determine whether TCF7L2 variants are major contributors to T2DM in Turkish populations. Our population comprised nonobese individuals to Background/aim: Type 2 diabetes (T2D) is a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like 2 (TCF7L2) gene shows the strongest association with T2D. In this study, we investigated whether TCF7L2 gene polymorphisms are associated with T2D in a Turkish population. Materials and methods:Using PCR-RFLP and PCR-SSCP, we genotyped six intronic polymorphisms in the TCF7L2 gene, commonly associated with T2D, in 169 individuals with diabetes and 119 healthy controls. Results:We found that rs7903146 C → T substitution in intron 3 (OR: 1.9, P = 0.005) and rs12255372 G → T substitution in intron 4 (OR: 2.1, P = 0.002) were significantly associated with T2D while other SNPs were not associated (P > 0.05). We determined no association between TCF7L2 gene polymorphisms and fasting glucose, fasting insulin, HbA1c, or HOMA-IR levels (P > 0.05), except for rs7903146 C → T substitution, which was significantly associated with the fastin...

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“…Despite increasing evidence that the TCF7L2 gene is associated with an increased T2DM risk in ethnic groups worldwide (Hayashi et al, 2007;Miyake et al, 2008;Palizban et al, 2012;Uma Jyothi et al, 2013;Wang et al, 2013), some studies presented the opposite conclusion (Chang et al, 2007;Ng et al, 2007;Zheng et al, 2012a). No consistent results have been reported because of the limited sample size and ethnicity heterogeneity in the studies.…”

Section: Discussionmentioning

confidence: 94%

Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis

Guan¹,

Yan²,

Liu³

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive meta-analysis was conducted to quantitatively assess the association between the TCF7L2 polymorphism (rs7903146) and T2DM including published case-control studies in global populations. We searched the PubMed, EMbase, CNKI, and Wanfang databases for publications that studied correlation between TCF7L2 polymorphism (rs7903146) and risk of T2DM. Thirty-six studies from 30 eligible papers were identified. After data extraction and reference quality assessment, summary odds ratio and 95% confidence intervals (95%CI) of the TCF7L2 (rs7903146) polymorphism were calculated and combined using the fixed-effect model. Hardy-Weinberg equilibrium was evaluated to determine selection bias of the control subjects. Heterogeneity among studies was examined using the Q-test and the I 2 test. Publication bias in studies was assessed using Begg's plots and the Egger test. The results showed that the rs7903146 T allele of the TCF7L2 gene was positively correlated with an enhanced risk of T2DM in the allelic, heterozygote, homozygote, dominant, and recessive models, with odds ratios of 1.35 (T vs C, 95%CI = 1.31-1.

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Association of a common variant in TCF7L2 gene with type 2 diabetes mellitus in a Persian population

Cited by 27 publications

References 28 publications

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

Association of the rs7903146 and rs12255372 polymorphisms in the TCF7L2 gene with type 2 diabetes in a population from northeastern Brazil

Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are strong predictorsof type 2 diabetes among nonobese diabetics in the Turkish population

Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis

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