Correlation of the TCF7L2 (rs7903146) polymorphism with an enhanced risk of type 2 diabetes mellitus: a meta-analysis

Abstract

ABSTRACT. Increasing evidence has demonstrated that a transcription factor 7-like 2 (TCF7L2) polymorphism (rs7903146) is significantly associated with type 2 diabetes mellitus (T2DM); however, limited sample size and variance of ethnicity in the studies investigating this association have led to conflicting reports regarding its role. Therefore, a comprehensive meta-analysis was conducted to quantitatively assess the association between the TCF7L2 polymorphism (rs7903146) and T2DM including published case-control studies in global populations. We searched the PubMed, EMbase, CNKI, and Wanfang databases for publications that studied correlation between TCF7L2 polymorphism (rs7903146) and risk of T2DM. Thirty-six studies from 30 eligible papers were identified. After data extraction and reference quality assessment, summary odds ratio and 95% confidence intervals (95%CI) of the TCF7L2 (rs7903146) polymorphism were calculated and combined using the fixed-effect model. Hardy-Weinberg equilibrium was evaluated to determine selection bias of the control subjects. Heterogeneity among studies was examined using the Q-test and the I 2 test. Publication bias in studies was assessed using Begg's plots and the Egger test. The results showed that the rs7903146 T allele of the TCF7L2 gene was positively correlated with an enhanced risk of T2DM in the allelic, heterozygote, homozygote, dominant, and recessive models, with odds ratios of 1.35 (T vs C, 95%CI = 1.31-1.

Associations of transcription factor 7-Like 2 (TCF7L2) gene polymorphism in patients of type 2 diabetes mellitus from Khyber Pakhtunkhwa population of Pakistan

“…A study from Scandinavian population demonstrated the association of T allele distribution with impaired secretion of insulin due to the proliferation beta cells of pancreas. Various meta-analyses demonstrated the association of common SNPs rs12255372 and rs7903146 as contributing factors for T2DM progression in diverse population like South Asian, Caucasian, East Asian and other ethnicities 16 , 32 , 33 , 34 . On the other hand, various studies from local populations of different countries established the link for disease susceptibility and TCF7L2 variations 12 , 14 , 35 .…”

DNA Methylation and Type 2 Diabetes: Novel Biomarkers for Risk Assessment?

“…Interestingly, these findings revealed that noncoding variants might affect human phenotypes [42]. The latter is also the case of the rs7903146 (C/T), located in the intron 4 of the transcription factor 7-like 2 (TCF7L2) gene, which is also the common variant with the strongest association with T2D and with an odds ratio (OR) of 1.35 (T vs. C, 95%CI = 1.31-1.39) [48][49][50]. While the average frequency of a T2D-associated risk allele across populations is 54% [51], the available data from genetic studies have led to the conclusion that the known genetic variants associated with T2D only marginally contribute to disease onset and may, at best, explain up to 15% of T2D heritability, thus generating the missing inheritance issue [44].…”

Parental History of Type 2 Diabetes Mellitus: A Lurking Genetic Threat

“…In insulin resistance there is an involvement of signal molecule-Resistin. Various confirmation specified that resisting applies its effect on C6H12O6 metabolism, will resist to fatty acid uptake and metabolism by the disturbing variety of objects such as CD36, fatty acid transport protein1, Acetyl-CoA carboxylase, and AMP-activated protein kinase [8].…”