Association of −634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm delivery

Abstract

An association was demonstrated between the VEGF 936C/T polymorphism and deliveries before 37 weeks of gestation.

Genetic variation associated with preterm birth: A HuGE review

“…100 There are a number of known polymorphisms in the VEGF gene including Ϫ1879 G/A, Ϫ1498 T/C, Ϫ1190 G/A, Ϫ1154 G/A, Ϫ634 C/G, Ϫ7 C/T, and 936 C/T. 101,102 A polymorphism at Ϫ634 (G to C) has been associated with increased serum levels of VEGF. 101 Diabetic patients with the Ϫ634 C allele are more likely to develop the vascular disease nonproliferative diabetic retinopathy than those with the Ϫ634 G major allele (OR 3.20; 95% CI 1.45-7.05; P ϭ .0046).…”

The 936C>T polymorphism of the gene for vascular endothelial growth factor is associated with 18F-fluorodeoxyglucose uptake

“…The T-variant, which is linked to lower VEGF levels, has been associated with breast cancer, sarcoidosis and spontaneous preterm delivery [6][7][8]. This suggests a potential role of the VEGF 936C>T polymorphism for the variability of FDG uptake in tumor tissue.…”

Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion

“…Many polymorphisms have been reported in the promoter and the 5 0 -and 3 0 -untranslated regions (UTRs) of the VEGF gene. These polymorphisms are associated with various diseases, including recurrent pregnancy loss, preeclampsia, Alzheimer's disease, and breast cancer (15)(16)(17)(18)(19)(20).…”