Association study of vascular endothelial growth factor polymorphisms with the risk of recurrent spontaneous abortion

Study of Genetic Polymorphisms of Vascular Endothelial Growth Factor in Women with Recurrent Abortion

“…And also this study revealed a statistically significant difference higher frequency of homozygous mutant genotype (GG) of VEGF C634G gen among cases compared to control, manifested by very high odds ratio [OR= 20.28 Ethnic heterogeneity is a key contributor to genetic association studies, including those on the association of VEGFA variant with RA, exemplified by the association of −963C/T with RSA in North Indians (23) and Greeks (24), but not in Brazilians (25) or Koreans (26).…”

“…In contrast, studies on Koreans (26) and Caucasians (30) indicated association between−1154G/A and RA risk, and homozygosity of VEGF −1154 A/A gene was described to serve as a susceptibility factor affecting the outcome of recurrent implantation failure (31).…”

Genetic variation in vascular endothelial growth factor gene and its association with recurrent spontaneous abortion

“…Magdoud et al (13) reported that homozygosity for some of the haplotypes in Bahraini population were associated with the lowest RSM risk in compari- son to other haplotype pairs studied. Other haploview analyses in different ethnic populations introduced protective haplotypes in VEGF SNPs studied (19,29). However, these fi ndings are based on haplotypes with different VEGF SNPs combinations and we cannot provide exact comparison of our data.…”

The Role of Vascular Endothelial Growth Factor Gene Polymorphisms in Recurrent Spontaneous Abortions in Saudi Women

“…This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Clearly disruption of this gene results in abnormal formation of blood vessel and the subsequent abnormal placental angiogenesis [16,17]. It was reported that VEGA gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression.…”