Association of 25-hydroxyvitamin D serum levels and metabolic parameters in psoriatic patients with and without arthritis

Orgaz‐Molina, Jacinto; Magro-Checa, César; Rosales-Alexander, José Luis; Arrabal-Polo, Miguel Ángel; Buendía‐Eisman, A.; Raya-Álvarez, Enriqué; Arias‐Santiago, Salvador

doi:10.1016/j.jaad.2013.08.007

Cited by 19 publications

(16 citation statements)

References 37 publications

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“…In a study performed among 15,484 patients from South Korea, 10.94% had dyslipidemia, including 14.88% of patients with PSA and 10.39% of patients with psoriasis [15]. In line with previous research, our study found that patients with PSA had more atherogenic lipid profiles than patients with psoriasis [27, 28]. Moreover, in our study, patients with PSA or psoriasis differed from controls with respect to all the studied parameters, except for the ApoA concentration.…”

Section: Discussionsupporting

confidence: 87%

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Pietrzak

Chabros

Grywalska

et al. 2019

aoms

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IntroductionPsoriasis and psoriatic arthritis (PSA) are chronic, inflammatory, systemic diseases characterized by metabolic abnormalities, including an increased cardiovascular risk and an oxidative imbalance. This study assessed blood parameters of lipid metabolism and markers of oxidative stress in patients with psoriasis and PSA.Material and methodsThe study included 93 patients with psoriasis (31 patients with PSA and psoriasis, 62 patients with psoriasis vulgaris), and 60 healthy, age-matched controls. Serum concentrations of the glucose and the following lipid metabolism parameters were measured: triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), high-density lipoproteins (HDL), and apolipoproteins A and B (ApoA, ApoB). Oxidative status was determined as serum concentrations of ox-LDL/MDA Adduct. The Psoriasis Area and Severity Index (PASI) was used to determine disease severity.ResultsAmong the three studied groups, controls had the highest HDL concentration (p < 0.001), patients with PSA had the highest ApoB concentration (p < 0.05), ApoA : ApoB ratio (p < 0.05), ox-LDL/MDA adduct concentration (p < 0.001), and TC: HDL and LDL : HDL ratios (accordingly p < 0.05, p < 0.01). In patients with psoriasis or PSA, oxidative status correlated positively with TC and ApoB concentrations.ConclusionsIn line with previous research, among patients with psoriasis and PSA, we found lipid metabolism abnormalities and an oxidative imbalance, which might be due to chronic inflammation in these conditions. Effective treatment of patients with psoriasis or PSA could reduce the risk of cardiovascular diseases.

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Section: Discussionsupporting

confidence: 87%

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Pietrzak

Chabros

Grywalska

et al. 2019

aoms

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“…Our reported results for these samples reflect the results from other nonhuman primate sample methodologies. While we had similar values to other human studies, our mean for 25(OH)D 3 was higher than reported for other studies [Orgaz‐Molina et al, ; Shinki et al, ]. The human samples we used are selected for the range they provide in values, and therefore, do not necessarily reflect the normal range found for humans.…”

Section: Discussionsupporting

confidence: 73%

Measurement of 25‐hydroxyvitamin D_2&3 and 1,25‐dihydroxyvitamin D_2&3 by tandem mass spectrometry: A primate multispecies comparison

Ziegler

Kapoor

Hedman

et al. 2015

American J Primatol

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Vitamin D metabolites are widely studied for their roles in bone health, immune functions and other potential physiologic roles in humans. However, the optimal blood levels of vitamin D metabolites are still unclear. Various methods for measuring vitamin D metabolites have been used and recently liquid chromatography tandem mass spectroscopy (LC-MS/MS) has been adopted as the gold standard for vitamin D metabolite measurement. Here we report the use of LC-MS/MS to measure 25-hydroxyvitamin D (25(OH)D2&3), and 1,25-dihydroxyvitamin D (1,25(OH)2D2&3), in three laboratory nonhuman primate species: common marmoset (Callithrix jacchus), rhesus macaque (Macaca mulatta), and cynomolgus macaque (Macaca fascicularis), and compare them to humans using the same technique. The nonhuman primates showed blood levels for 25(OH)D3 and 1,25(OH)2D3 significantly higher than human values with marmosets having the highest levels. Marmoset samples showed significantly more variability among individuals than those from macaques for both metabolites, but all three nonhuman primate species exhibited large variation within species for both 25(OH)D2&3 and 1,25(OH)2D2&3. Marmoset females had significantly lower values than the males for 25(OH)D3, while rhesus males showed a significant decrease in 25(OH)D3 with age. The most striking finding is the variation within species for vitamin D levels even in laboratory primates that have a controlled diet, UV exposure, and in some cases, genetic constraints. Similar variation in 25(OH)D responses to a fixed dose of oral vitamin D supplementation has been reported in humans. We suggest that these species can provide primate models for examining the factors influencing variation in the levels of vitamin D necessary for human and nonhuman primate health.

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“…6.19-21 In another study, the inverse correlations between vitamin D serum level and atherosclerotic lipid profile in psoriatic patients was described. 22 The current study results revealed a remarkable relationship between the twelve-week vitamin D supplementation and an improvement of lipid profile. A significant blood lipid reduction (TC, LDL-C, and TG), and an increase in HDL-C level after the intervention period were observed.…”

Section: Discussionsupporting

confidence: 52%

The role of high-dose vitamin D supplementation on disease severity and lipid profile in psoriatic patients: A pilot study

Prtina¹,

Grabež²,

Vujnic³

et al. 2020

Scripta Medica

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Background/Aim: Psoriasis is a chronic inflammatory skin disease that is associated with a higher prevalence of cardiovascular (CV) risk factors. The effect of vitamin D on bone health has been long known, but its extraskeletal role especially in cardiovascular disease and skin disease, is the subject of recent research. This study aimed to assess the influence of high-dose vitamin D supplementation on the Psoriasis Area and Severity Index (PASI) score and lipid profile in patients with psoriasis. Methods: The study included 20 adult patients with chronic plaque psoriasis. They received vitamin D capsules in a daily dose of 5,000 IU over 12 weeks. Measured serum concentrations of lipid metabolism parameters were triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL) and high-density lipoproteins (HDL). PASI was used to determine the severity of the disease. Results: High-doses vitamin D supplementation had a significant influence on reduction in PASI score in all patients (17.99 ± 12.42 vs 10.27 ± 8.53; p < 0.001). The supplementation of high dose vitamin D induced statistically significant lowering of the TC, LDL-C and TG in the psoriatic patients (p < 0.05). Furthermore, significant increase in serum HDL-C level was observed. The change of PASI score showed week positive correlation with the changes in serum TC and LDL-C (r = 0.303, p = 0.03 and r = 0.357 p = 0.013). Conclusion: High-dose vitamin D supplementation had a positive impact on clinical status of the chronic plaque psoriasis patients, measured by PASI score. It also improved the serum lipid profile of these patients. Double-blinded prospective studies are needed in order to get more comprehensive data related to vitamin D, lipid metabolism and severity of psoriasis.

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Association of 25-hydroxyvitamin D serum levels and metabolic parameters in psoriatic patients with and without arthritis

Cited by 19 publications

References 37 publications

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Measurement of 25‐hydroxyvitamin D_2&3 and 1,25‐dihydroxyvitamin D_2&3 by tandem mass spectrometry: A primate multispecies comparison

The role of high-dose vitamin D supplementation on disease severity and lipid profile in psoriatic patients: A pilot study

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Association of 25-hydroxyvitamin D serum levels and metabolic parameters in psoriatic patients with and without arthritis

Cited by 19 publications

References 37 publications

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Serum lipid metabolism in psoriasis and psoriatic arthritis – an update

Measurement of 25‐hydroxyvitamin D2&3 and 1,25‐dihydroxyvitamin D2&3 by tandem mass spectrometry: A primate multispecies comparison

The role of high-dose vitamin D supplementation on disease severity and lipid profile in psoriatic patients: A pilot study

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Measurement of 25‐hydroxyvitamin D_2&3 and 1,25‐dihydroxyvitamin D_2&3 by tandem mass spectrometry: A primate multispecies comparison