Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians

Trajkov, Dejan; Mishevska-Perchinkova, Snezhana; Karadzova-Stojanoska, Anzelika; Petlichkovski, Aleksandar; Strezova, Ana; Спироски, Мирко

doi:10.1007/s10067-009-1238-4

Cited by 83 publications

(85 citation statements)

References 16 publications

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“…Healthy subjects were recruited from the patient pool at the Clinic for Oral Diseases and Periodontology, University Clinical Centre of Stomatology, Skopje, Macedonia (17)(18)(19). All subjects were over 20 years of age, had at least 20 teeth present, were from Macedonian ethnic background to the third generation, and were unrelated residents from different geographical regions of the Republic of Macedonia.…”

Section: Methodsmentioning

confidence: 99%

IL1 cluster gene polymorphisms in macedonian patients with chronic periodontitis

Atanasovska-Stojanovska

Поповска²,

Trajkov³

et al. 2013

BLL

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Several studies have investigated the genetic polymorphisms for cytokines as potential genetic markers for periodontitis. The aim of this study was to determine the prevalence of IL1 cluster genes polymorphisms and their association with chronic periodontitis in the Macedonian population. The group of 114 unrelated Macedonian subjects with chronic periodontitis and 301 periodontitis-free Macedonian subjects were studied. DNA was isolated from peripheral blood leukocytes by phenol-chloroform extraction method. Cytokine genotyping was performed by PCR-SSP. The population genetics analysis package (PyPop) was used for analysis of the cytokine data for this report. Crude odds ratio (OR) was calculated as estimates of the relative risk with 95 % confi dence interval (CI). Genotype frequency of IL1B -511/C:T was signifi cantly higher in patients with periodontitis than in controls (OR=2.11, 95 % CI=1.35-3.32, p=0.001). IL1 cluster gene haplotype frequencies of TTTCT and TCTTT were associated with higher risk for periodontitis (OR=5.06, 95 % CI=1. p<0.0014 and OR=8.35, p<0.002, respectively). No signifi cant association of IL1 composite genotype (IL1 -889A:IL1B +3962) with periodontitis in Macedonians was found. The latter association was found to be signifi cant in genotype IL1B -511/C:T, haplotype TTTCT, and haplotype TCTTT, but without signifi cant association in IL1 composite genotype (Tab. 5, Ref. 43). Full Text in PDF www.elis.sk.

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Section: Methodsmentioning

confidence: 99%

IL1 cluster gene polymorphisms in macedonian patients with chronic periodontitis

Atanasovska-Stojanovska

Поповска²,

Trajkov³

et al. 2013

BLL

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“…In this context, an earlier study carried out in patients with pulmonary TB revealed that the combination of the IFNG +874 polymorphism and allele A homozygosity was associated with significantly lower levels of IFNG compared to those in individuals carrying one or two copies of the T allele 7,8 .…”

Section: Introductionmentioning

confidence: 92%

“…Several polymorphisms in the promoter region of the IFN-γ gene (IFNG), in particular those at position +874, are considered to influence the levels of expression of this cytokine. Several studies have demonstrated the association of this single nucleotide polymorphism (SNP) with susceptibility towards, and severity of, this disease 7,8 . Local and systemic IFN-γ levels correlate with TB severity.…”

Section: Introductionmentioning

confidence: 99%

Concordance between IFNγ gene +874 A/T polymorphism and interferon-γ expression in a TB-endemic indigenous setting

Araujo

Palacios

Biomon

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction: Interferon-γ (IFN-γ) plays a crucial role in resistance to mycobacterial diseases; accordingly, variants of the gene encoding this cytokine may be associated with elevated risk of contracting pulmonary tuberculosis (TB). Methods: Blood samples were collected from 135 Warao indigenous individuals with newly diagnosed sputum culture-positive TB. Of these, 24 were diagnosed with active tuberculosis (ATB). The study comprised 111 participants, who were grouped as follows: 1) 14 tuberculin skin test (TST)-positive Warao indigenous individuals and 4 that were QuantiFERON-TBGold In-Tube (QFT-IT) test-positive, collectively comprising the latent TB infection group (LTBI), n = 18), and 2) healthy controls who were QFT-ITand TST-negative, comprising the control group (CTRL, n = 93). Detection of the IFN γ gene (IFNG) +874A/T polymorphism was performed via PCR and quantification of IFNG expression via qPCR. Results: Relative to indigenous and white Americans, ATB and CTRL groups had a higher frequency of the IFNG SNP (+874A): 23 (95.8%) and 108 (97.3%), respectively. Indigenous Warao individuals homozygous for the IFNG (+874) A allele exhibited 3.59-fold increased risk of developing TB (95% confidence interval, 2.60-4.96, p =0.0001). A decreased frequency of the AT genotype was observed in individuals with pulmonary TB (4.16%) and controls (0.90%). The frequency of the TT genotype was decreased among controls (1.80%); none of the patients with TB were found to have this genotype. The differences in IFNG expression between the groups, under unstimulated and stimulated conditions, were not statistically significant. Conclusions: Preliminary results demonstrate concordance between IFNG +874 A/A genotype and low expression of IFNG.

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“…The study of cytokine gene polymorphisms is a helpful tool to predict the genetic susceptibility to diseases in special communities. Polymorphism in cytokine genes are known to influence cytokine levels and may also be associated with susceptibility/resistance to tuberculosis or outcome and clinical forms of this disease (9)(10)(11)(12)(13). The pattern of cytokine gene polymorphisms is different in various populations (14).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Genetic Polymorphisms of TNF-α and IL-10 Genes Between Tuberculosis Patients and Healthy Blood Donors

Metanat

Narooie‐Nejad

Salehi

et al. 2013

Arch Clin Infect Dis

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Association of 22 cytokine gene polymorphisms with rheumatoid arthritis in population of ethnic Macedonians

Cited by 83 publications

References 16 publications

IL1 cluster gene polymorphisms in macedonian patients with chronic periodontitis

IL1 cluster gene polymorphisms in macedonian patients with chronic periodontitis

Concordance between IFNγ gene +874 A/T polymorphism and interferon-γ expression in a TB-endemic indigenous setting

Comparison of Genetic Polymorphisms of TNF-α and IL-10 Genes Between Tuberculosis Patients and Healthy Blood Donors

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