Association between Vitamin D Deficiency and Psoriasis: A Case-Control Study

Allayali, Ahmed Zahr; Niaz, Ghassan; Hawsawi, Khalid Al; Fatani, Mohammad I.; Siddiqui, Irfanullah; Baghdadi, Razan; Sulimani, Hatim Al; Hawsawi, Waseem Al

doi:10.4172/2155-9554.1000442

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…Psoriasis appears to be influenced by genetic and immune-mediated pathological mechanisms. The pathogenesis of psoriasis is still not completely understood, but psoriasis is associated with excessive T-cell activity, as well as keratinocyte differentiation [3,4], and different pro-inflammatory mediators such as tumor necrosis factor-α, interleukin (IL)-17, and IL-23 [5]. The worldwide prevalence is approximately 1-3% [6].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in Patients With Psoriasis and Psoriatic Arthritis

Mohammed

Mathkhor

Khudhairy

2020

Asian J Pharm Clin Res

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Objective: The objective of this study is to investigate the association between Vitamin D level and psoriasis, in particular in our city of the long, hot, and sunny weather, in an attempt to add a clarification to this controversial subject. Methods: A case–control study included 120 patients with psoriasis and 38 patients with psoriatic arthritis (PsA); 89 (56.3%) patients were male. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score using 28 joints (DAS28) and erythrocyte sedimentation rate (DAS28) was measured for all patients with PsA. The control group comprised 164 age- and sex-matched participants (91 males and 73 females). Vitamin D serum level was performed for both patients and controls. Results: Vitamin D levels in both patients and controls were 17.4±7.7 and 28.3±5.6, respectively. The level of Vitamin D was lower in a patient with disease duration equal and more than 10 years than those with a disease duration <10 years. There is no significant difference in Vitamin D levels between the two patient subgroups. Lower Vitamin D levels were associated with high PASI and high DAS28 in psoriasis and PsA, respectively. Conclusion: Patients with psoriasis and PsA associated with low levels of serum Vitamin D. Vitamin D deficiency was found to be associated with long disease duration in both psoriasis and PsA. Patients with active disease have lower Vitamin D levels.

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Section: Introductionmentioning

confidence: 99%

Vitamin D Deficiency in Patients With Psoriasis and Psoriatic Arthritis

Mohammed

Mathkhor

Khudhairy

2020

Asian J Pharm Clin Res

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“…1 In fact, psoriasis is now recognised as a systemic pathology that includes a variety of problems, such as psoriatic arthritis, obesity, and metabolic disorders, all of which enhance a patient's risk of cardiovascular disease. 2,3 The 50-79% of patients with skin psoriasis and up to 80% of those with psoriatic arthritis (Psoriatic arthritis) may experience nail problem. 1 Mukherjee D et al Int J Res Med Sci.…”

Section: Introductionmentioning

confidence: 99%

Association of vitamin D3 with psoriasis and psoriatic arthritis-an observational study

Mukherjee,

Nandi,

Naiya

et al. 2023

Int J Res Med Sci

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Background: The objective of this study is to investigate the association between 25 (OH) vit D3 level and psoriasis, in our city with long sunny weather, in an attempt to clarify the controversies. Methods: The 100 patients with psoriasis including 29 with psoriatic arthritis were taken randomly as cases from medicine outpatient department of KPCMCH. Psoriasis area and severity index (PASI) was calculated for all patients with psoriasis and disease activity score (DAS28-CRP) in all arthritis patients. The control group had 150 age and sex-matched participants without any symptoms related to psoriasis or psoriatic arthritis. The 25 (OH) vit D3 serum level was estimated for both groups. This is an observational, cross-sectional study. Results: Out of total 100 patients, 55% were male and 45% female, with mean age and disease duration 49.7±6.7 years and 11.4±3.5 years, respectively. The control group had 150 subjects (86 males, 64 females). The 25 (OH) vit D3 levels of both patients and controls were 19.2±8.5 ng/ml and 29.9±6.7 ng/ml, respectively and the difference was statistically significant (p<0.05). The 25(OH) vit D3 levels were 21.9±4.1 ng/ml in patients with disease duration <10 years, and 15.9±4.2 ng/ml in patients with disease duration ≥ 10 years and difference was statistically significant (p<0.05). It was 18.9±7.8 ng/ml and 20.1±8.4 ng/ml respectively in psoriasis patients with and without arthritis but the difference was statistically not significant (p>0.05). The 25(OH) vit D3 level was lower in psoriasis with high PASI compared to psoriasis with low-moderate PASI and lower in psoriatic arthritis with high disease activity compared to arthritis with low-moderate disease activity. Conclusions: Both psoriasis and psoriatic arthritis patients had lower 25 (OH) vit D3 levels. The disease durations were directly related to 25 (OH) vit D3 insufficiency. Lower levels were associated with higher active diseases.

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“…4 Further, among case-control studies published between 2019 and 2021, few of them showed significant association between 25(OH) D levels and psoriasis, [5][6][7][8][9] while other remaining studies did not show a significant association between level of 25(OH) D with psoriasis. [10][11][12][13][14] Hence in conclusion from the literature review of clinical studies available to date, the association between psoriasis and vitamin D is still controversial.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

Pokharel¹,

Agrawal²,

Pandey³

et al. 2022

PTT

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Background Chronic plaque psoriasis is a chronic inflammatory skin disorder. Vitamin D has been shown to have effects on keratinocyte differentiation as well as immune regulation in the skin. Objective The main objective of this study was to assess the 25hydroxyvitamin D [25 (OH) D] level in patients with psoriasis in comparison with healthy control subjects. Materials and Methods This case–control study included 180 persons (120 cases and 60 age- and sex-matched control subjects) from outpatient department of BPKIHS, a tertiary care hospital in eastern Nepal. Severity of psoriatic skin lesions was assessed using psoriasis area severity index (PASI) scoring. Serum vitamin D level was assessed by chemiluminescent immunoassay. Results The mean serum 25(OH) D levels in psoriatic patients and controls were 19.57 ± 6.85 ng/mL and 23.63 ± 6.40 ng/mL, respectively. The difference was statistically significant even after adjusting for confounding factors in a multivariate analysis (aOR 2.929, 95% CI 1.376–6.230). Low serum 25(OH) D levels were negatively associated with the severity of disease (r= −0.628, P= 0.01). Conclusion Serum 25(OH) D levels are significantly lower in psoriatic patients than in healthy control subjects. Deficiency of serum 25(OH) D was associated with severity of disease with an inverse relationship with PASI score.

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Association between Vitamin D Deficiency and Psoriasis: A Case-Control Study

Cited by 3 publications

References 30 publications

Vitamin D Deficiency in Patients With Psoriasis and Psoriatic Arthritis

Vitamin D Deficiency in Patients With Psoriasis and Psoriatic Arthritis

Association of vitamin D3 with psoriasis and psoriatic arthritis-an observational study

Assessment of Vitamin D Level in Patients with Psoriasis and Its Correlation with Disease Severity: A Case–Control Study

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