Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women

Rivera‐Paredez, Berenice; Hidalgo‐Bravo, Alberto; Cruz-Montoya, Aldo de la; Martínez-Aguilar, Mayeli M.; Ramírez‐Salazar, Eric G.; Flores, Mario; Quezada-Sánchez, Amado D.; Ramírez-Palacios, Paula; Cid, Miguel; Martínez‐Hernández, Angélica; Orozco, Lorena; Denova‐Gutiérrez, Edgar; Salmerón, Jorge; Velázquez‐Cruz, Rafael

doi:10.1007/s40618-019-01177-5

Cited by 6 publications

(7 citation statements)

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“…Finally, bone tissue mineralization and intestinal microbiota are determined by several factors, including vitamin D levels [ 50 ]. Previously reported studies on the Mexican population described a high prevalence of vitamin D deficiency in postmenopausal women [ 15 ]. Here, for the first time, vitamin D-deficiency-associated alterations in the microbiota in postmenopausal women were reported.…”

Section: Discussionmentioning

confidence: 99%

“…Data for this study was collected by the third assessment (January–December 2018) of the HWCS population performed from 2016 to 2018. All enrolled participants answered a questionnaire for the sociodemographic characteristics (birth date, education level, medical history, medical history of relatives, medication use, diet, physical activity, smoking status, alcohol consumption) [ 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…Based on the serum vitamin D levels, two groups were performed. The vitamin D deficiency (VDD) group was defined as serum 25 hydroxyvitamin D (25(OH)D) levels <20 ng/mL, and the vitamin D non-deficient (VDND) group as serum 25(OH)D ≥20 ng/mL, as previously reported [ 15 ]. To determine body mass index (BMI) (kg/m 2 ), the following anthropometric measurements were obtained: weight and height following standardized procedures applied by trained personnel.…”

Section: Methodsmentioning

confidence: 99%

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A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a Relationship between Diet, Metabolites, and Microbiota

et al. 2020

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The effect of microbiota composition and its health on bone tissue is a novel field for research. However, their associations with bone mineral density (BMD) have not been established in postmenopausal women. The present study investigates the relation of diet, the microbiota composition, and the serum metabolic profile in postmenopausal women with normal-BMD or with low-BMD. Ninety-two Mexican postmenopausal women were classified into normal-BMD (n = 34) and low-BMD (n = 58). The V4 hypervariable region was sequenced using the Miseq platform. Serum vitamin D was determined by chemiluminescence immunoassay. Serum concentrations of acyl-carnitines and amino acids were determined by electrospray tandem mass spectrometry. Diet was assessed by a food frequency questionnaire. The low-BMD group had fewer observed species, higher abundance of γ-Proteobacteria, lower consumption of lycopene, and lower concentrations of leucine, valine, and tyrosine compared with the normal-BMD group. These amino acids correlated positively with the abundance of Bacteroides. Lycopene consumption positively correlated with Oscillospira and negatively correlated with Pantoea genus abundance. Finally, the intestinal microbiota of women with vitamin D deficiency was related to Erysipelotrichaceae and Veillonellaceae abundance compared to the vitamin D non-deficient group. Associations mediated by the gut microbiota between diet and circulating metabolites with low-BMD were identified.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a Relationship between Diet, Metabolites, and Microbiota

et al. 2020

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“…To test this hypothesis and to limit confounding bias (latitude, etc), we focused on the countries whose DBP polymorphisms at rs7041 and rs4588 loci were defined and the allele frequencies reported in five cohort and two systematic review and meta‐analysis studies 8‐15 . We searched the literature for DBP gene polymorphism in each country.…”

Section: Methodsmentioning

confidence: 99%

The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Batur

Hekim

2020

Journal of Medical Virology

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Since December 2019, coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2, has given rise to emerging respiratory infections with pandemic diffusion. The vitamin D binding protein (DBP) with emphasis on its regulation of total and free vitamin D metabolite levels participate in various clinical conditions. The main goal of this study was to evaluate if there was any association between the DBP gene polymorphism at rs7041 and rs4588 loci and the prevalence of COVID‐19 and its mortality rates caused among populations of 10 countries including Turkey. Positive significant correlations were found between the prevalence (per million) and mortality rates (per million), and GT genotype ( P < .05) while there was a negative significant correlation between prevalence (per million) and mortality rates (per million), and TT genotype at rs7041 locus among all populations ( P < .05). However, no significant correlation was found at rs4588 locus. GT genotype was found to confer this susceptibility to the populations of Germany, Mexico, Italy, Czech, and Turkey. The variations in the prevalence of COVID‐19 and its mortality rates among countries may be explained by Vitamin D metabolism differed by the DBP polymorphisms of rs7041 and rs4588 .

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“…In a sample of postmenopausal Native women from Mexico, the serum vitamin D levels were deficient in ~45% of the sample (Rivera‐Paredez et al, 2020). In another study, with Native American children living in Great Plains USA states, it was shown that 97% of them had a deficient level of vitamin D (Nsiah‐Kumi et al, 2012); a similar result obtained with Natives recruited from Oklahoma State (Ritterhouse et al, 2014).…”

Section: Native Americans: Skin Color and Vitamin Dmentioning

confidence: 99%

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

Missaggia

Reales

Cybis

et al. 2020

American J of Med Genetics Pt C

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We carried out an exhaustive review regarding human skin color variation and how much it may be related to vitamin D metabolism and other photosensitive molecules. We discuss evolutionary contexts that modulate this variability and hypotheses postulated to explain them; for example, a small amount of melanin in the skin facilitates vitamin D production, making it advantageous to have fair skin in an environment with little radiation incidence. In contrast, more melanin protects folate from degradation in an environment with a high incidence of radiation. Some Native American populations have a skin color at odds with what would be expected for the amount of radiation in the environment in which they live, a finding challenging the so‐called “vitamin D–folate hypothesis.” Since food is also a source of vitamin D, dietary habits should also be considered. Here we argue that a gene network approach provides tools to explain this phenomenon since it indicates potential alleles co‐evolving in a compensatory way. We identified alleles of the vitamin D metabolism and pigmentation pathways segregated together, but in different proportions, in agriculturalists and hunter‐gatherers. Finally, we highlight how an evolutionary approach can be useful to understand current topics of medical interest.

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Association between vitamin D deficiency and common variants of Vitamin D binding protein gene among Mexican Mestizo and indigenous postmenopausal women

Cited by 6 publications

References 47 publications

A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a Relationship between Diet, Metabolites, and Microbiota

A Multi-Omic Analysis for Low Bone Mineral Density in Postmenopausal Women Suggests a Relationship between Diet, Metabolites, and Microbiota

The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Adaptation and co‐adaptation of skin pigmentation and vitamin D genes in native Americans

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