The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Batur, Lutfiye Karcioglu; Hekim, Nezih

doi:10.1002/jmv.26409

Cited by 52 publications

(45 citation statements)

References 36 publications

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“…Age may be another important factor to consider as a significant interaction between age and vitamin D deficiency was observed for associations with COVID-19 severity in one study ( 215 ). Other important considerations include genetic influences, with significant associations between polymorphisms in the vitamin D-binding protein and the prevalence and mortality due to COVID-19 reported ( 261 ). How ethnicity affects our capacity to make vitamin D after exposure to sun exposure (or UVB radiation) is a further important factor, which has been discussed ( 121 , 262 ).…”

Section: Vitamin D and Covid-19mentioning

confidence: 99%

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Gorman

Weller

2020

Front. Cardiovasc. Med.

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During the COVID-19 (coronavirus disease of 2019) pandemic, researchers have been seeking low-cost and accessible means of providing protection from its harms, particularly for at-risk individuals such as those with cardiovascular disease, diabetes and obesity. One possible way is via safe sun exposure, and/or dietary supplementation with induced beneficial mediators (e.g., vitamin D). In this narrative review, we provide rationale and updated evidence on the potential benefits and harms of sun exposure and ultraviolet (UV) light that may impact COVID-19. We review recent studies that provide new evidence for any benefits (or otherwise) of UV light, sun exposure, and the induced mediators, vitamin D and nitric oxide, and their potential to modulate morbidity and mortality induced by infection with SARS-CoV-2 (severe acute respiratory disease coronavirus-2). We identified substantial interest in this research area, with many commentaries and reviews already published; however, most of these have focused on vitamin D, with less consideration of UV light (or sun exposure) or other mediators such as nitric oxide. Data collected to-date suggest that ambient levels of both UVA and UVB may be beneficial for reducing severity or mortality due to COVID-19, with some inconsistent findings. Currently unresolved are the nature of the associations between blood 25-hydroxyvitamin D and COVID-19 measures, with more prospective data needed that better consider lifestyle factors, such as physical activity and personal sun exposure levels. Another short-coming has been a lack of measurement of sun exposure, and its potential to influence COVID-19 outcomes. We also discuss possible mechanisms by which sun exposure, UV light and induced mediators could affect COVID-19 morbidity and mortality, by focusing on likely effects on viral pathogenesis, immunity and inflammation, and potential cardiometabolic protective mechanisms. Finally, we explore potential issues including the impacts of exposure to high dose UV radiation on COVID-19 and vaccination, and effective and safe doses for vitamin D supplementation.

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Section: Vitamin D and Covid-19mentioning

confidence: 99%

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Gorman

Weller

2020

Front. Cardiovasc. Med.

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“…The relationship between these GWAS associations and race was not explored in this study. A recent paper suggested that these SNPs in the DBP gene, specifically in the rs7041 locus, correlated with the prevalence (GT genotype: r=0.73, p=0.02; TT genotype: r=−0.62, p=0.04) and mortality (GT genotype: r=0.87, p=0.01; TT genotype: r=−0.66, p=0.04) rates of COVID-19 among all investigated populations [ 6 ]. More in detail, subjects with a TT genotype had a higher COVID-19 susceptibility in China, Japan, Nigeria, and Kenya.…”

Section: To the Editormentioning

confidence: 99%

Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19

Speeckaert

Delanghe

2021

Eur Respir J

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With interest, we read the paper of Faniyi et al . [1], which investigated the relationship between vitamin D status and seroconversion for COVID-19 in UK healthcare workers. More specifically, vitamin D deficiency was an independent risk factor for the development of COVID-19 seroconversion, with the biggest differences seen in the Black Asian and minority ethnic (BAME) male group. Although several co-morbidities were taken into account, we would like to highlight the importance of vitamin D binding protein (DBP) and its polymorphism in the interpretation of low 25-hydroxyvitamin D [25(OH)D] levels in the BAME population with COVID-19.

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“…A recent study has showed the rs7041 locus to be associated with increased risk of COVID-19 infection and mortality [19] . Therefore, the association of the genetic polymorphisms of DBP and COVID-19 may depend on the modulatory pleiotropic effects of the bioavailable vitamin D levels.…”

mentioning

confidence: 99%

A genetic insight into vitamin D binding protein and COVID-19

Alshahawey

2021

Medical Hypotheses

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It’s since December 2019 that Corona virus disease (COVID-19) has emerged to be the global issue of concern. A “pandemic”; this is what WHO has declared about the COVID-19 outbreak on March 3rd, 2020. Vitamin D and its deficiency have recently been claimed to be one of the potential factors affecting COVID-19 risks and outcomes [1] . As Selberstein et al., has recently discussed the effect of vitamin D deficiency, and the role of vitamin D supplementation in COVID-19 patients [2] , I’d believe that vitamin D binding protein (DBP) is maybe also involved. A closer look on DBP and its action on regulating the circulatory vitamin D levels, its polymorphisms and their impact on COVID-19 prevalence and mortality, will be briefly discussed.

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The role of DBP gene polymorphisms in the prevalence of new coronavirus disease 2019 infection and mortality rate

Cited by 52 publications

References 36 publications

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Investigating the Potential for Ultraviolet Light to Modulate Morbidity and Mortality From COVID-19: A Narrative Review and Update

Genetic polymorphisms, vitamin D binding protein and vitamin D deficiency in COVID-19

A genetic insight into vitamin D binding protein and COVID-19

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