Association between vitamin D and hepatitis C virus infection: A meta-analysis

Abstract

Our results demonstrated high prevalence of vitamin D deficiency and high SVR in individuals with higher serum vitamin D levels or receiving vitamin D supplementation.

Association between serum vitamin D and severity of liver fibrosis in chronic hepatitis C patients: a systematic meta-analysis

“…The heterogeneity between the individual studies and the potential publication bias was also evaluated. This meta-analysis is different from that reported by Villar et al (2013), which focused on the association between 25(OH) D and sustained virological response (SVR) in HCVinfected individuals.…”

Vitamin D level and sustained virologic response to interferon-based antiviral therapy in chronic hepatitis C: A systematic review and meta-analysis

“…While Villar et al reported vitamin D supplementation to improve SVR in genotypes 1, 2, and 3 [24] we believe that the question of whether vitamin D supplementation improves SVR to interferon-based antiviral therapy needs to be addressed by an appropriately powered randomized, placebo-controlled trial. The three vitamin D supplementation studies included in their meta-analysis involved a small number of participants and was limited by the lack of a placebo-controlled arm [12,13] and a retrospective design [14].…”

Vitamin D and Calcium Abnormalities in the HIV-Infected Population

“…[115][116][117] Studies conducted among Hepatitis C monoinfected patients have shown independent association of vitamin D deficiency with treatment failure and severe liver fibrosis. [118][119][120] The exact mechanism of its antiviral effect is unknown, although it was recently shown to amplify the innate antiviral immune response by upregulating the expression of interferon-b and the MxA gene and dampening IP-10 expression. 115,121 Furthermore, vitamin D has been shown to directly inhibit the proliferation and the profibrotic effect of hepatic stellate cells.…”