Association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk: Evidence from epidemiologic studies

Huang, Xiaolun; Yuan-fu, Gao; Zhi, Xiaosong; Ta, Na; Jiang, Hui; Zheng, Jianming

doi:10.1038/srep38936

Cited by 48 publications

(42 citation statements)

References 48 publications

(66 reference statements)

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“…Interestingly, we obtained a consistent result in the cohort studies although we included 5 cohort studies, which is two more than Koushik et al Previous meta-analyses had been published to assess the intake of vitamin A and cancer risk. Huang et al and Zhang et al had explored the association between vitamin A intake and pancreatic cancer [27,28], they obtained a consistent result, which might inversely correlate with pancreatic cancer while with vitamin A intake. Yu et al concluded that higher category of dietary vitamin A intake could reduce the risk of lung cancer [29].…”

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confidence: 80%

Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

2020

Bioscience Reports

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BACKGROUND: Previous studies have demonstrated some associations between dietary vitamin A intake and ovarian cancer risk with an inconsistent relationship. We therefore performed the present study to further explore the association between them. METHODS: Databases of PubMed, Embase, and Web of Science were retrieved up to September 1, 2019. Summarized relative risk (RR) with corresponding 95% confidence intervals (CI) were calculated. Stata 14.0 software was used for data analysis. RESULTS: Fifteen articles involving 4882 cases and 443,179 participants were included in this meta-analysis. A positive association between dietary vitamin A intake and ovarian cancer risk was found (RR = 0.816, 95%CI = 0.723–0.920, I2 = 48.4%, Pfor heterogeneity = 0.019). Significant association was also found in case–control studies (RR = 0.769, 95%CI = 0.655–0.902), but not in cohort studies. When we performed the analysis between ovarian cancer risk and geographic locations, we found an inverse association in North American populations (RR = 0.825, 95%CI = 0.720–0.946), instead of other populations. CONCLUSIONS: In summary, findings from the present study suggested that higher dietary intake of vitamin A may contribute to the lower development of ovarian cancer, especially among North Americans.

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Section: Figure 3 Funnel Plot For the Analysis Of Publication Bias Bmentioning

confidence: 80%

Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

2020

Bioscience Reports

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“…Recent studies indicate that lycopene intake has protective functions against cardiovascular diseases by lowering high-density lipoprotein (HDL)-associated inflammation [69]. It was proposed that there is an inverse association between the occurrence of pancreatic cancer and dietary lycopene intake together with vitamin A and β-carotene [70]. β-Carotene 9′,10′-oxygenase which is a key enzyme for the metabolism of lycopene has been proposed to have an important roles to prevent prostate cancer progression by inhibiting NF-κB signaling [71].…”

Section: Antioxidant Functions Of Carotenoids At Molecular Level For mentioning

confidence: 99%

The Biochemistry and Antioxidant Properties of Carotenoids

Merhan¹

2017

Carotenoids

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Carotenoids are one of the most widespread pigment groups distributed in nature, and more than 700 natural carotenoids have been described so far, and new carotenoids are introduced each year. Carotenoids are derived from 4 terpenes, including totally 40 carbon atoms. Carotenoids are naturally synthesized by cyanobacteria, algae, plants, some fungi, and some bacteria, but not made by mammals. Lately, the beneficial properties of α-carotene, β-carotene, γ-carotene, lycopene, phytoene, phytofluene, lutein, zeaxanthin, β-cryptoxanthin, astaxanthin, and fucoxanthin carotenoids in prevention of various diseases, such as tumor formation, cardiovascular, and vision, have been documented due to their roles as antioxidants, activation in certain gene expression associated with cell-to-cell communication, provitamin A activity, modulation of lipoxygenase activity, and immune response. In this chapter, in addition to biochemical properties of carotenoids, how the structure of these molecules influences the oxidative stress in health and reducing the risk of formation of various diseases will be described.

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“…Skin carotenoid levels therefore reflect a good diet-rich in fruit and vegetables (Stephen et al, 2011;Whitehead et al, 2012)-but carotenoids could also act as a more general cue to human health. Reduced blood plasma carotenoid levels have been linked to a variety of disease states including HIV infection (Friis et al, 2001), malaria (Das et al, 1996), risk of some cancers (Leoncini et al, 2015;Huang et al, 2016), and myocardial infarction (Street et al, 1994); however, objective measures of health in terms of immune function, sperm status, and oxidative stress in normal adults have not been found to relate consistently to skin carotenoids (Foo et al, 2017a,b;Phalane et al, 2017). Our study explores the relationship between other aspects of health and carotenoid-based skin color.…”

Section: Introductionmentioning

confidence: 99%

Skin Color Cues to Human Health: Carotenoids, Aerobic Fitness, and Body Fat

et al. 2020

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Colorful carotenoid ornaments are sexually selected signals of health in many species. In humans too, carotenoids could provide a perceptible cue to health as they impart an attractive yellow-orange color to skin. Increasing carotenoid pigmentation and skin yellowness is associated with increased fruit and vegetable intake, but whether other aspects of human health benefit skin color is unknown. Carotenoids, as antioxidants, help maintain oxidative balance but are expended in this role. Therefore, any health factor affecting oxidative balance could alter the quantity of carotenoids available to color skin. Exercise increases endogenous antioxidant capacity and consequently may decrease expenditure of carotenoids. Fitness could also raise skin carotenoids by lowering body fat (a source of oxidative stress). Here we investigate the relationship between skin color (measured spectrophotometrically), aerobic fitness (measured by estimating the maximum volume of oxygen that a person can use per unit of time, VO 2 max), and body fat. In a cross-sectional design, we find that both higher aerobic fitness and lower body fat are predictors of skin yellowness, independent of each other and dietary fruit and vegetable intake. In a longitudinal design over 8 weeks, we found that increase in fitness and decrease in body fat were independently associated with an increase in skin yellowness. Change in self-reported stress and sleep were further predictors of skin yellowness indicating a more general relation between health and skin tone. Simulations of the skin color associated with higher fitness were found to appear healthier. Hence, our results suggest that increasing cardiovascular fitness and decreasing fat levels produce a healthier skin color. Such findings have repercussions for public health because improved attractiveness can provide an incentive for a healthier lifestyle, including exercise and weight regulation.

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Association between vitamin A, retinol and carotenoid intake and pancreatic cancer risk: Evidence from epidemiologic studies

Cited by 48 publications

References 48 publications

Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

The Biochemistry and Antioxidant Properties of Carotenoids

Skin Color Cues to Human Health: Carotenoids, Aerobic Fitness, and Body Fat

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