Dietary vitamin A intake and the risk of ovarian cancer: a meta-analysis

Abstract

BACKGROUND: Previous studies have demonstrated some associations between dietary vitamin A intake and ovarian cancer risk with an inconsistent relationship. We therefore performed the present study to further explore the association between them. METHODS: Databases of PubMed, Embase, and Web of Science were retrieved up to September 1, 2019. Summarized relative risk (RR) with corresponding 95% confidence intervals (CI) were calculated. Stata 14.0 software was used for data analysis. RESULTS: Fifteen articles involving 4882 cases and 443,179 participants were included in this meta-analysis. A positive association between dietary vitamin A intake and ovarian cancer risk was found (RR = 0.816, 95%CI = 0.723–0.920, I2 = 48.4%, Pfor heterogeneity = 0.019). Significant association was also found in case–control studies (RR = 0.769, 95%CI = 0.655–0.902), but not in cohort studies. When we performed the analysis between ovarian cancer risk and geographic locations, we found an inverse association in North American populations (RR = 0.825, 95%CI = 0.720–0.946), instead of other populations. CONCLUSIONS: In summary, findings from the present study suggested that higher dietary intake of vitamin A may contribute to the lower development of ovarian cancer, especially among North Americans.

Review of Mendelian Randomization Studies on Ovarian Cancer

“…Vitamin A activity is important for normal control of cellular differentiation and proliferation and hypothesized to modify cancer risk. Interestingly, a previous study exploring the correlation between vitamin A levels and risk of OC demonstrated no association while a subsequent meta-analysis reached the opposite conclusion (79,80). A further MR analysis using two SNPs on a Caucasian population showed no causal link between vitamin A levels and risk of OC (37).…”

Recursos ergogênicos nutricionais no esporte: luzes e sombras sobre o seu emprego

“…Podem ainda não ser devidamente absorvidos se não houver estratégias de ingestão que favoreçam sua biodisponibilidade de absorção. Alguns suplementos podem interagir negativamente com alguns medicamentos, como exemplo, a ação da vitamina K na redução da ação anticoagulante da varfarina (derivado cumarínico que atua como antagonista da vitamina K, utilizado na profilaxia e tratamento de diversas doenças tromboembólicas e suas complicações) (Polito et al, 2019); suplementos com dose elevadas de vitaminas C e E podem reduzir a eficácia de algumas categorias de quimioterapia contra o câncer (Burns et al, 2013); o excesso de vitamina A pode causar cefaléia, danos hepáticos e reduzir a resistência óssea (Wang & He, 2020); o excesso de ferro pode causar náuseas e vômitos e danificar órgãos internos, como o fígado e competir com cálcio (Pietrangelo, 2016).…”

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

“…Chronopoulou et al, has reported that extraction of vit A from Tetradesmus Obliquus is in the highest amount through supercritical fluid extraction method (Chronopoulou et al, 2019). Higher intake of dietary Vit A can remarkably decrease the ovarian, lung, gastric, pancreatic, and cervical carcinoma risk (Sanusi, 2019;Wang and He, 2020). Retinoic acid activates the extracellular-signal-regulated kinase (ERK) pathway and thus, promotes angiogenesis and metastasis in lung cancer.…”

“…Higher intake of dietary Vit A can remarkably decrease the ovarian, lung, gastric, pancreatic, and cervical carcinoma risk ( Sanusi, 2019 ; Wang and He, 2020 ). Retinoic acid activates the extracellular-signal-regulated kinase (ERK) pathway and thus, promotes angiogenesis and metastasis in lung cancer.…”