Association between vascular endothelial growth factor gene polymorphisms and PCOS risk: a meta-analysis

Li, Yuxi; Fang, Lanlan; Yu, Yiping; Shi, Hao; Wang, Sijia; Li, Yiran; Ma, Yujia; Yang, Yan; Sun, Yingpu

doi:10.1016/j.rbmo.2019.10.018

Cited by 9 publications

(3 citation statements)

References 39 publications

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“…Given that elevated AMH levels are near ubiquitous in PCOS populations, propositions have been attempted to incorporate AMH levels as a possible diagnostic tool for PCOS [ 28 ]. Unlike AMH, VEGF is better understood for its role in ovarian angiogenesis than in the pathogenesis of PCOS [ 29 ].…”

Section: Pathophysiology Of Pcos—current Understanding Based On the Known And The Hypothesizedmentioning

confidence: 99%

A Narrative Review of Current Understanding of the Pathophysiology of Polycystic Ovary Syndrome: Focus on Plausible Relevance of Vitamin D

Kalyanaraman

Pal

2021

IJMS

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Polycystic ovarian syndrome (PCOS) is the most prevalent endocrinopathy of reproductive years. Salient features in presentation of patients PCOS include menstrual dysfunction, hyperandrogenism and/or polycystic appearance of ovaries on ultrasound. While the diagnosis of PCOS depends on presence of specified criteria, misdiagnoses are common. Despite years of extensive research, the exact aetiology of PCOS remains largely unknown. In the past decade, apart from insulin resistance and hyperandrogenemia, anti-mullerian hormone (AMH), an important marker of ovarian reserve, and vascular endothelial growth factor (VEGF), a crucial factor in angiogenesis, have been examined as plausible players of causative relevance for PCOS. Vitamin D, a sex-steroid hormone that is universally known for its relevance for skeletal health, has received increasing attention due to growing evidence supporting its pivotal in reproductive physiology and in PCOS. In this review we summarize our current understanding of the mechanisms relevant to the pathophysiology of PCOS and examine the role of vitamin D signalling in this context.

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Section: Pathophysiology Of Pcos—current Understanding Based On the Known And The Hypothesizedmentioning

confidence: 99%

A Narrative Review of Current Understanding of the Pathophysiology of Polycystic Ovary Syndrome: Focus on Plausible Relevance of Vitamin D

Kalyanaraman

Pal

2021

IJMS

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“…The VEGF gene is located in the chromosome region 6p21.3 5 . Single-nucleotide polymorphisms (SNPs) have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested VEGF gene polymorphisms may be associated with PCOS risk [6][7][8] . VEGF rs833061 T and rs2010963 G alleles appear to correlate with altered VEGF expression levels.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

Vicente

Marqui

Gomes

et al. 2022

Rev. Assoc. Med. Bras.

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OBJECTIVE:The polycystic ovary syndrome is the most common endocrine disorder, characterized by the dysregulation of ovarian angiogenesis. This alteration can be related to changes in the activities of the vascular endothelial growth factor (VEGF) gene. Single-nucleotide polymorphisms have been observed in the promoter, intronic, and untranslated regions of the VEGF gene, and several studies have suggested that these polymorphisms may be associated with the risk of polycystic ovary syndrome. This study aimed to investigate the association between rs2010963 and rs833061 polymorphisms and haplotypes of VEGF in the etiology of polycystic ovary syndrome. METHODS: A total of 210 women, 102 diagnosed with polycystic ovary syndrome and 108 controls, participated in this study. The genotyping of the samples was performed by PCR-RFLP and real-time PCR for rs2010963 and rs833061 polymorphisms, respectively. The statistical analyses were performed by the chi-square test and logistic regression model. RESULTS:The clinical characteristics of the patients showed that 75.8% of the patients did not become pregnant, 36.3% had a family history of polycystic ovary syndrome, 58.6% were obese, and about 60% had clinical characteristics of hyperandrogenism. There were no associations between the distribution of rs2010963 (OR 1.24; 95%CI 0.60-2.57; p=0.56) and rs833061 (OR 0.78; 95%CI 0.32-1.92; p=0.59) in patients and controls. CONCLUSIONS: The patients with polycystic ovary syndrome have similar rates of VEGF polymorphisms rs2010963 and rs833061 on the general population.

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“…Some studies have explored the pathophysiological roles of cytokines, such as interleukin-1b (IL-1b), interleukin-1 receptor antagonist (IL1Ra), interleukin-6 (IL-6), interleukin-17 (IL-17) and interleukin-18 in PCOS development (6,7). The association of the pathogenesis of PCOS with growth factors, such as vascular endothelial growth factor (VEGF), fibroblast growth factor (FGF) and pigment epithelium-derived factor (PEDF) has also been investigated by previous studies (8)(9)(10). Previous studies have also found that anti-inflammatory therapy can benefit patients with PCOS (11).…”

Section: Introductionmentioning

confidence: 99%

The Association Between Genetically Predicted Systemic Inflammatory Regulators and Polycystic Ovary Syndrome: A Mendelian Randomization Study

Chen

Zhang

et al. 2021

Front. Endocrinol.

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic diseases among women of reproductive age. Inflammation may be involved in the pathogenesis of PCOS, but its exact relationship with PCOS remains unclear. Herein, we investigate the causal association between systemic inflammatory regulators and PCOS risk through a two-sample Mendelian randomization (MR) approach based on the latest and largest genome-wide association study (GWAS) of 41 systemic inflammatory regulators in 8293 Finnish participants and a GWAS meta-analysis consisting of 10,074 PCOS cases and 103,164 controls of European ancestry. Our results suggest that higher levels of IL-17 and SDF1a, as well as lower levels of SCGFb and IL-4, are associated with an increased risk of PCOS (OR = 1.794, 95% CI = 1.150 – 2.801, P = 0.010; OR = 1.563, 95% CI = 1.055 – 2.315, P = 0.026; OR = 0.838, 95% CI = 0.712 – 0.986, P = 0.034; and OR = 0.637, 95% CI = 0.413 – 0.983, P = 0.042, respectively). In addition, genetically predicted PCOS is related to increased levels of IL-2 and VEGF (OR = 1.257, 95% CI = 1.022 – 1.546, P = 0.030 and OR = 1.112, 95% CI = 1.006 – 1.229, P = 0.038, respectively). Our results indicate the essential role of cytokines in the pathogenesis of PCOS. Further studies are warranted to assess the possibility of these biomarkers as targets for PCOS prevention and treatment.

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Association between vascular endothelial growth factor gene polymorphisms and PCOS risk: a meta-analysis

Cited by 9 publications

References 39 publications

A Narrative Review of Current Understanding of the Pathophysiology of Polycystic Ovary Syndrome: Focus on Plausible Relevance of Vitamin D

A Narrative Review of Current Understanding of the Pathophysiology of Polycystic Ovary Syndrome: Focus on Plausible Relevance of Vitamin D

Polymorphisms rs2010963 and rs833061 of the VEGF gene in polycystic ovary syndrome

The Association Between Genetically Predicted Systemic Inflammatory Regulators and Polycystic Ovary Syndrome: A Mendelian Randomization Study

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