Association Between Urinary IgG and Relative Risk for Factors Affecting Proteinuria in Type 2 Diabetic Patients

Mohan, Sandesh; Kalia, Kiran; Mannari, Jyoti

doi:10.1007/s12291-012-0227-6

Cited by 7 publications

(7 citation statements)

References 50 publications

(46 reference statements)

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“…When the glomerular filtration barrier is damaged, these proteins can pass through the glomeruli into the urine. Some studies have also shown that the level of IgG could represent the severity of kidney damage, and the deposition of IgG in the kidney has often indicated poor prognosis of the disease [25][26][27]. In our study, we found that both IgG and Alb were deposited in the glomeruli, and their urine levels were in direct proportion to the extent of glomerular lesions, which suggests that these macromolecular protein levels may be a good indicator of glomerular lesions.…”

Section: Discussionsupporting

confidence: 68%

Correlation analysis between Tervaert glomerular classification and clinical indicators in patients with type 2 diabetic nephropathy

Zhao

2022

Diabetic Nephropathy

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Purpose To investigate the correlation analysis of Tervaert glomerular classification and clinical indicators in patients with type 2 diabetic nephropathy (DN). Methods We collected the renal sections of patients with DN and used immunoglobulin G (IgG), albumin (Alb), PAS, and MASSON staining to observe the extent of glomerular lesions. We simultaneously collected their clinical data for statistics and conducted correlation analysis with Tervaert glomerular classification. Moreover, we collected patients’ urine protein components data and conducted a correlation analysis with Tervaert classification. Results Tervaert classification reflects glomerular changes and was positively related to proteinuria, creatinine (Cr), and blood urea nitrogen but was negatively related to estimated glomerular filtration rate (eGFR). Tervaert classification was also positively related to total protein (TP), transferrin (TRF), retinol binding protein (RBP), N-acetyl-β-D aminoglucosidase (NAG), Alb, cystatin C (Cyc), IgG, β2-microglobulin (β2-MG), α1-microglobulin (α1-MG), Alb/Cr, and TP/Cr in urine. Conclusion Our study reveals that clinical indicators could well reflect glomerular lesions and has great value for the diagnosis and treatment of early DN.

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Section: Discussionsupporting

confidence: 68%

Correlation analysis between Tervaert glomerular classification and clinical indicators in patients with type 2 diabetic nephropathy

Zhao

2022

Diabetic Nephropathy

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“…The associations of glomerular damage markers (IgG, TFR) with DKD have been previously described, but most researches showed that the urinary levels of IgG and TFR paralleled the degree of urinary albumin excretion . Mohan et al . suggested that IgG levels represent the seriousness of kidney lesions.…”

Section: Discussionmentioning

confidence: 99%

Associations of urinary, glomerular, and tubular markers with the development of diabetic kidney disease in type 2 diabetes patients

Zhang

Wang

et al. 2017

Clinical Laboratory Analysis

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“…Furthermore, glycosylation also plays an important role in glomerular basement membrane (GBM) and podocyte damage, during progression to diabetic nephropathy (37). Alterations in the neonatal Fc receptor (FcRn), that plays a pivotal role for the recycling and clearance of antibodies, may contribute to the increases in the renal and non-renal clearances of IgG (38).…”

Section: Discussionmentioning

confidence: 99%

Effect of Type 2 Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability in the Rat

Chadha

Morris

2015

AAPS J

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Abstract. The objective of this research was to assess the effects of type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN) on the pharmacokinetics of human IgG (hIgG), an antibody isotype, in Zucker diabetic fatty (ZDF) rats. Furthermore, the specific role of T2DM in the altered disposition of hIgG was evaluated by treating diabetic rats with pioglitazone, while the role of chronic kidney disease (CKD) was assessed using 5/6 nephrectomized Sprague Dawley rats. ZDF male (lean non-diabetic control and obese diabetic) and pioglitazone-treated ZDF rats were studied at ages 12-13 weeks (only DM was present), and at ages 29-30 weeks (progression to DN). All animals were dosed with 1 mg/kg of hIgG intravenously (IV) or subcutaneously (SC). ZDF rats had significantly higher blood glucose concentrations and urinary albumin excretion compared to control rats. Significant increases in total clearance (2.5-fold) and renal clearance (100-fold) of hIgG were observed; however the major increase in total clearance was due to increased non-renal clearance. Greater changes in urinary albumin excretion and total and renal clearances of IgG (3.5-fold and 300-fold, respectively) were observed with progression to DN. SC bioavailability of hIgG in all animal groups was similar (>84%). With pioglitazone-treatment, diabetic animals remained euglycemic and treatment was able to reverse the clearance changes, although incompletely. In the CKD group, no difference in hIgG clearance was observed when compared with controls. In conclusion, the increased clearance of hIgG in ZDF diabetic animals, reversal by pioglitazone treatment and lack of effect of CKD, demonstrate the influence of T2DM on hIgG pharmacokinetics.

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Association Between Urinary IgG and Relative Risk for Factors Affecting Proteinuria in Type 2 Diabetic Patients

Cited by 7 publications

References 50 publications

Correlation analysis between Tervaert glomerular classification and clinical indicators in patients with type 2 diabetic nephropathy

Correlation analysis between Tervaert glomerular classification and clinical indicators in patients with type 2 diabetic nephropathy

Associations of urinary, glomerular, and tubular markers with the development of diabetic kidney disease in type 2 diabetes patients

Effect of Type 2 Diabetes Mellitus and Diabetic Nephropathy on IgG Pharmacokinetics and Subcutaneous Bioavailability in the Rat

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