Association between UGT1A1 Polymorphism and Risk of Laryngeal Squamous Cell Carcinoma

Abstract

Laryngeal cancer is one of the largest subgroups of head and neck cancers. In addition to smoking and alcohol consumption, genetic polymorphisms are also risk factors for the development of laryngeal cancer. However, the exact relation between genetic variants and pathogenesis of laryngeal cancer has remained elusive. The aim of this study was to examine UGT1A1*6 (rs4148323 A/G) polymorphisms in 103 patients with laryngeal cancer and 220 controls using the high resolution melting curve (HRM) technique and to explore the association between UGT1A1*6 (rs4148323 A/G) polymorphisms and laryngeal cancer. The results showed an association between the rs4148323 G allele and increased risk of laryngeal cancer. While there was no statistically significant difference between rs4148323 genotype frequencies and different histological grades or different clinical stages of laryngeal cancer, stratification analysis indicated smoking or alcohol consumption and rs4148323 G allele combined to increase the risk of laryngeal cancer. In conclusion, the rs4148323 G allele is associated with the high UGT1A1 enzyme activity, and might increase the risk of laryngeal cancer. Furthermore, smoking or alcohol consumption and the rs4148323 G allele act synergistically to increase the risk of laryngeal cancer.

Effect of DACH1 on proliferation and invasion of laryngeal squamous cell carcinoma

“…These results were similar to previous studies on the expression of DACH1 in esophageal cancer, hepatocellular carcinoma and colorectal cancer [ 10 , 18 , 19 ]. Smoking and alcohol consumption were risk factors of laryngeal carcinoma, and DACH1 increased the risk of laryngeal carcinoma which is consistent with other study [ 12 ].…”

“…We analyzed gender, age, smoking, drinking, T classification, lymph node metastases, primary location and histopathological differentiation, which were obtained from patient records. Smoking and alcohol consumption were calculated according to [ 12 ].…”

Knockdown of circ_0001883 may inhibit epithelial‑mesenchymal transition in laryngeal squamous cell carcinoma via the miR‑125‑5p/PI3K/AKT axis

“…The primary type is laryngeal squamous cell carcinoma (LSCC), which accounts for 5% of all types of human cancer (2). Tobacco, alcohol and genetic polymorphisms are the main risk factors for the development of LSCC (3). There are three traditional treatments of LSCC: Surgery, radiotherapy and chemotherapy, either alone or in combination (4).…”

Uridine 5'‑diphospho‑glucronosyltrasferase: Its role in pharmacogenomics and human disease (Review)

“…It has been reported that this null genotype is associated with BC; it has also been suggested that the UGT2B17 enzyme serves a role in cancer drug metabolism (71). Finally, a study reported that smoking or alcohol consumption combined with the G allele of the UGT1A1*6 gene (rs4148323 A/G) increased the risk of laryngeal cancer (27). Further examples of the association between cancer and UGT variants are cited in Table I.…”