Association Between Tumor Necrosis Factor-α-<i>308G/A</i> Polymorphism and Obstructive Sleep Apnea: A Meta-Analysis

Huang, Jian; Liao, Ning; Huang, Qiu-Pin; Xie, Zijian

doi:10.1089/gtmb.2011.0170

Cited by 21 publications

(18 citation statements)

References 13 publications

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“…Compared with the previous meta-analysis performed by Huang et al [35], our study had several superiorities. Firstly, the previous study identified less than half the number of studies as compared with the present study.…”

Section: Discussionmentioning

confidence: 64%

TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies

Cao

et al. 2014

PLoS ONE

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ObjectiveThe aim of our study was to investigate the association between the TNF-α-308G/A polymorphism and obstructive sleep apnea syndrome (OSAS).MethodThe Medline, Web of Science, EMBASE, Chinese National Knowledge Infrastructure (CNKI), and Cochrane Central Register of Controlled Trials were searched. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to study TNF-α-308G/A polymorphism and risk of OSAS.Result10 case-control studies were included in our meta-analysis. The results from our study showed that the TNF-α-308G/A polymorphism was significantly associated with risk of OSAS (A vs. G: OR = 1.67, 95% CI = 1.43–1.95). In the subgroup analysis by ethnicity, the statistical similar results were observed both in European (A vs. G: OR = 1.68, 95% CI = 1.35–2.08) and Asian population (A vs. G: OR = 2.02, 95% CI = 1.50–2.71). When stratified by age, a significantly increased risk was observed in adult carries A allele compared with G allele (OR = 1.79, 95% CI = 1.50–2.13), whereas no association was found in children (OR = 1.09, 95% CI = 0.70–1.69).ConclusionOur study suggested that the TNF-α- 308G/A polymorphism contributed to the susceptibility to the risk of OSAS. Additional well-designed large studies are needed to validate our findings.

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Section: Discussionmentioning

confidence: 64%

TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies

Cao

et al. 2014

PLoS ONE

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“…These findings were supported by many other independent studies in multiple experimental models over time (for example, see (da Costa et al, 2016) and a complete list at www.metaflammation.org). While less definitive human genetics associations in which TNF polymorphisms have been linked to obesity, diabetes and other aspects of metabolic syndrome, including polycystic ovary syndrome and sleep apnea also started to emerge (Huang et al, 2012a; Sookoian et al, 2005). Many other inflammatory cytokines and mediators such as interleukin 1β (IL-1β) have since been implicated in the pathogenesis of insulin action or secretion (Maedler et al, 2002), leading to thousands of publications.…”

Section: Signaling Pathways Connecting Immunity and Glucose Metabolismentioning

confidence: 99%

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

2017

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Highly ordered interactions between immune and metabolic responses are evolutionarily conserved and paramount for tissue and organismal health. Disruption of these interactions underlies the emergence of many pathologies, particularly chronic non-communicable diseases such as obesity and diabetes. Here, we examine decades of research identifying the complex immunometabolic signaling networks and the cellular and molecular events that occur in the setting of altered nutrient and energy exposures and offer a historical perspective. Furthermore, we describe recent advances such as the discovery that a broad complement of immune cells play a role in immunometabolism and the emerging evidence that nutrients and metabolites modulate inflammatory pathways. Lastly, we discuss how this work may eventually lead to tangible therapeutic advancements to promote health.

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“…Other studies and three recent meta-analyses have also failed to confirm the role of other candidate genes for MetS with the exception of TNFα (Lee et al, 2011; Varvarigou et al, 2011; Huang et al, 2012). On the other hand, both syndromes are largely complex diseases determined by a large number of genes, and some of them are probably the same.…”

Section: Discussionmentioning

confidence: 98%

“…Unfortunately none of them have been consistently replicated. Recently published meta-analyses have investigated the role of APOE, TNFα and ACE gene polymorphisms in OSA pathogenesis, but they only found a statistical significant association for the TNFα gene (Lee et al, 2011; Varvarigou et al, 2011; Huang et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Genetic analysis of candidate SNPs for metabolic syndrome in obstructive sleep apnea (OSA)

Grilo

Ruiz-Granados²,

Moreno-Rey³

et al. 2013

Gene

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Obstructive sleep apnea (OSA) is a common disorder characterized by the reduction or complete cessation in airflow resulting from an obstruction of the upper airway. Several studies have observed an increased risk for cardiovascular morbidity and mortality among OSA patients. Metabolic syndrome (MetS), a cluster of cardiovascular risk factors characterized by the presence of insulin resistance, is often found in patients with OSA, but the complex interplay between these two syndromes is not well understood. In this study, we present the results of a genetic association analysis of 373 candidate SNPs for MetS selected in a previous genome wide association analysis (GWAS). The 384 selected SNPs were genotyped using the Illumina VeraCode Technology in 387 subjects retrospectively assessed at the Internal Medicine Unit of the “Virgen de Valme” University Hospital (Seville, Spain). In order to increase the power of this study and to validate our findings in an independent population, we used data from the Framingham Sleep study which comprises 368 individuals. Only the rs11211631 polymorphism was associated with OSA in both populations, with an estimated OR=0.57 (0.42-0.79) in the joint analysis (p=7.21 × 10-4). This SNP was selected in the previous GWAS for MetS components using a digenic approach, but was not significant in the monogenic study. We have also identified two SNPs (rs2687855 and rs4299396) with a protective effect from OSA only in the abdominal obese subpopulation. As a whole, our study does not support that OSA and MetS share major genetic determinants, although both syndromes share common epidemiological and clinical features.

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Association Between Tumor Necrosis Factor-α-308G/A Polymorphism and Obstructive Sleep Apnea: A Meta-Analysis

Abstract: The TNF-α-308G/A polymorphism contributes to the risk of OSA, especially in adults.

Cited by 21 publications

References 13 publications

TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies

TNF-α-308G/A Polymorphism Contributes to Obstructive Sleep Apnea Syndrome Risk: Evidence Based on 10 Case-Control Studies

Foundations of Immunometabolism and Implications for Metabolic Health and Disease

Genetic analysis of candidate SNPs for metabolic syndrome in obstructive sleep apnea (OSA)

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