Association between Toxoplasma gondii infection and metabolic syndrome in obese adolescents: A possible immune-metabolic link

Salem, Doaa A.; Salem, Nanees; Hendawy, Shimaa R.

doi:10.1016/j.parint.2021.102343

Cited by 7 publications

(8 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Despite differences in obesity in pediatric and adult patients, similar trends in chemerin levels were observed in most studies [32]. Most studies conducted in children have found higher levels of the molecule in overweight/obese individuals than in lean children [33][34][35][36][37][38][39], and only one report found no differences in chemerin levels between children with overweight/obesity and normal BMI [40]. In patients with atrophy of adipose tissue in the course of anorexia nervosa, the concentration of chemerin was lower than in the group of obese and healthy peers [41].…”

Section: Chemerin and Obesitysupporting

confidence: 60%

“…Higher concentrations of the molecule were associated with increases in serum triglyceride (TG), total cholesterol and low-density lipoprotein cholesterol (LDL-C), as well as low levels of highdensity lipoprotein cholesterol (HDL-C) [27,33,37,38,42]. Apart from lipid dysregulation, it plays a role in glucose metabolism and positively correlates with homeostatic model assessment for insulin resistance (HOMA-IR) [33,34,[37][38][39]. There have been conflicting results regarding the link between chemerin and glucose.…”

Section: Chemerin and Obesitymentioning

confidence: 99%

See 1 more Smart Citation

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

2022

View full text Add to dashboard Cite

Adipose tissue is the main source of adipokines and therefore serves not only as a storage organ, but also has an endocrine effect. Chemerin, produced mainly in adipocytes and liver, is a natural ligand for chemokine-like receptor 1 (CMKLR1), G-protein-coupled receptor 1 (GPR1) and C-C motif chemokine receptor-like 2 (CCRL2), which have been identified in many tissues and organs. The role of this protein is an active area of research, and recent analyses suggest that chemerin contributes to angiogenesis, adipogenesis, glucose homeostasis and energy metabolism. Many studies confirm that this molecule is associated with obesity in both children and adults. We conducted a systematic review of data from published studies evaluating chemerin in children with various disease entities. We searched PubMed to identify eligible studies published prior to February 2022. A total of 36 studies were selected for analysis after a detailed investigation, which was intended to leave only the research studies. Moreover, chemerin seems to play an important role in the development of cardiovascular and digestive diseases. The purpose of this review was to describe the latest advances in knowledge of the role of chemerin in the pathogenesis of various diseases from studies in pediatric patients. The mechanisms underlying the function of chemerin in various diseases in children are still being investigated, and growing evidence suggests that this adipokine may be a potential prognostic biomarker for a wide range of diseases.

show abstract

Section: Chemerin and Obesitysupporting

confidence: 60%

Section: Chemerin and Obesitymentioning

confidence: 99%

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

2022

View full text Add to dashboard Cite

show abstract

“…Those phenomena are related to metabolic syndrome. Additionally, the prevalence of metabolic syndrome was higher in patients who belonged to the T gondii- seropositive group than a T. gondii -seronegative group [ 147 ].…”

Section: Adipocytes As Infection Targets and Their Relationship With ...mentioning

confidence: 99%

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

López‐Ortega

Moreno-Corona

Cruz-Holguin

et al. 2022

IJMS

View full text Add to dashboard Cite

The current obesity pandemic has been expanding in both developing and developed countries. This suggests that the factors contributing to this condition need to be reconsidered since some new factors are arising as etiological causes of this disease. Moreover, recent clinical and experimental findings have shown an association between the progress of obesity and some infections, and the functions of adipose tissues, which involve cell metabolism and adipokine release, among others. Furthermore, it has recently been reported that adipocytes could either be reservoirs for these pathogens or play an active role in this process. In addition, there is abundant evidence indicating that during obesity, the immune system is exacerbated, suggesting an increased susceptibility of the patient to the development of several forms of illness or death. Thus, there could be a relationship between infection as a trigger for an increase in adipose cells and the impact on the metabolism that contributes to the development of obesity. In this review, we describe the findings concerning the role of adipose tissue as a mediator in the immune response as well as the possible role of adipocytes as infection targets, with both roles constituting a possible cause of obesity.

show abstract

“…Although the data are strong due to the number and quality of the data, as well as the multiple confounders we have tried to control, there are many possible explanations of this statistically significant association. Toxoplasma gondii infection has been shown to be associated with deregulated metabolic functions [21,22] and cardiovascular disease burden [3]. The factors that increase metabolic diseases can also increase the risk for toxoplasmosis acquisition.…”

Section: Discussionmentioning

confidence: 99%

The association between Toxoplasma infection and mortality: the NHANES epidemiologic follow-up study

et al. 2022

View full text Add to dashboard Cite

Background Toxoplasma gondii has been reported to be associated with higher mortality in patients with schizophrenia. This study aimed to explore the relationship between T. gondii infection and 25-year mortality based on data from the Third National Health and Nutrition Examination Survey (NHANES III) database. Methods Cases with serum T. gondii antibody test results were included in this study and the corresponding mortality dataset was obtained from the US National Center for Health Statistics (NCHS). Propensity score matching (PSM) was used to match age and sex between groups. The Cox proportional hazards model was used to evaluate the effect of T. gondii infection on mortality. Results A total of 14,181 cases were included in the analysis, of which 3831 (27.0%) were seropositive for T. gondii antibody. The median follow-up time of the whole cohort was 22.5 (interquartile range 16.3, 24.5) years. A total of 5082 deaths were observed in this cohort, a mortality rate of 35.8%. All-cause mortality was significantly higher in the seropositive group than in the seronegative group (50.0% vs 30.6%, P < 0.001). Kaplan–Meier analysis showed a significant difference in the survival time between two groups before and after PSM. Multivariate analysis showed that T. gondii infection was independently associated with higher all-cause mortality after adjusting for potential confounders. Conclusions Toxoplasma gondii infection is associated with higher mortality in general population. Graphical Abstract

show abstract

Association between Toxoplasma gondii infection and metabolic syndrome in obese adolescents: A possible immune-metabolic link

Cited by 7 publications

References 51 publications

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

Chemerin as Potential Biomarker in Pediatric Diseases: A PRISMA-Compliant Study

The Immune Response in Adipocytes and Their Susceptibility to Infection: A Possible Relationship with Infectobesity

The association between Toxoplasma infection and mortality: the NHANES epidemiologic follow-up study

Contact Info

Product

Resources

About