Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism

Torres, Ana Cláudia M.B. Gomes; Leite, Neiva; Tureck, Luciane Viater; Souza, Ricardo Lehtonen Rodrigues de; Titski, Ana Cláudia Kapp; Milano-Gai, Gerusa E; Lazarotto, Leilane; Silva, Larissa Rosa da; Furtado-Alle, Lupe

doi:10.1016/j.gene.2018.11.065

Cited by 23 publications

(15 citation statements)

References 43 publications

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“…It additionally involves inhibition of reverse cholesterol transport (RCT) at multiple points, including decreased hepatic production of apolipoprotein A1, cholesterol ester transfer protein (CETP), ATP binding cassette transporters ABCG5 and ABCG8, and Cyp7a1. These findings are consistent with the association found of the lipopolysaccharide receptor Toll-like receptor 4 (TLR4) and NIMA-related kinase 7 (NEK7) polymorphisms with LDL-C in human (Zhu et al, 2015;Gomes Torres et al, 2019). NEK7 is a serine/threonine kinase required for NLRP3 (NOD-, LRR-and pyrin domain-containing protein 3) inflammasome assembly.…”

Section: Gut Microbiota and Cholesterol Traits In Preclinical Modelssupporting

confidence: 89%

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Villette

Béliard

et al. 2020

Front. Pharmacol.

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Disruption in cholesterol metabolism, particularly hypercholesterolemia, is a significant cause of atherosclerotic cardiovascular disease. Large interindividual variations in plasma cholesterol levels are traditionally related to genetic factors, and the remaining portion of their variance is accredited to environmental factors. In recent years, the essential role played by intestinal microbiota in human health and diseases has emerged. The gut microbiota is currently viewed as a fundamental regulator of host metabolism and of innate and adaptive immunity. Its bacterial composition but also the synthesis of multiple molecules resulting from bacterial metabolism vary according to diet, antibiotics, drugs used, and exposure to pollutants and infectious agents. Microbiota modifications induced by recent changes in the human environment thus seem to be a major factor in the current epidemic of metabolic/inflammatory diseases (diabetes mellitus, liver diseases, inflammatory bowel disease, obesity, and dyslipidemia). Epidemiological and preclinical studies report associations between bacterial communities and cholesterolemia. However, such an association remains poorly investigated and characterized. The objectives of this review are to present the current knowledge on and potential mechanisms underlying the host-microbiota dialogue for a better understanding of the contribution of microbial communities to the regulation of cholesterol homeostasis.

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Section: Gut Microbiota and Cholesterol Traits In Preclinical Modelssupporting

confidence: 89%

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Villette

Béliard

et al. 2020

Front. Pharmacol.

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“…In recent years, NEK7-mediated NLRP3 inflammasome activation has been reported to be involved in various inflammatory diseases (Xu et al, 2016;Chen X. et al, 2019;Gomes Torres et al, 2019). A significant correlation was shown between gene polymorphisms in NEK7, TLR (toll-like receptors), NLR (nod-like receptors), and lipid and glucose parameters from healthy children and adolescents and adults (Gomes Torres et al, 2019).…”

Section: Diseases Related To the Nlrp3 Inflammasomementioning

confidence: 99%

Physiological and Pathological Roles of Mammalian NEK7

2020

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NEK7 is the smallest NIMA-related kinase (NEK) in mammals. The pathological and physiological roles of NEK7 have been widely reported in many studies. To date, the major function of NEK7 has been well documented in mitosis and NLRP3 inflammasome activation, but the detailed mechanisms of its regulation remain unclear. This review summarizes current advances in NEK7 research involving mitotic regulation, NLRP3 inflammasome activation, related diseases and potential inhibitors, which may provide new insights into the understanding and therapy of the diseases associated with NEK7, as well as the subsequent studies in the future.

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“…Notably, NIMA‐related kinase 7 (NEK7), a serine/threonine kinase playing vital roles in mitosis, is required for the NLRP3 inflammasome assembly by binding NLRP3, which occurs after K + efflux, and a recent study has reported a significant increase of NLRP3 and NEK7 in both mRNA and protein levels in patients with systemic lupus erythematosus after drug treatment . Furthermore, the polymorphisms in gene levels of NEK7 and toll‐like receptors (TLRs) are associated with change of cholesterol levels, suggesting NEK7 is potentially involved in immunometabolism. Collectively, inflammasome activation is crucial for host defence against microbes and implicated in metabolic disorders; thus, tight regulation is required.…”

Section: Regulation Of Inflammasome Activation In Inflammationmentioning

confidence: 99%

Metabolic regulation of inflammasomes in inflammation

Yang

Liu

et al. 2019

Immunology

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Summary Inflammasome activation and subsequent inflammatory cytokine secretion are essential for innate immune defence against multiple stimuli and are regarded as a link to adaptive immune responses. Dysfunction of inflammasome activation has been discovered at the onset or progression of infectious diseases, autoimmune diseases and cancer, all of which are also associated with metabolic factors. Furthermore, many studies concerning the metabolic regulation of inflammasome activation have emerged in recent years, especially regarding the activity of the NLRP3 inflammasome under metabolic reprogramming. In this review, we discuss the molecular mechanisms of the interactions between metabolic pathways and inflammasome activation, which exerts further important effects on various diseases.

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Association between Toll-like receptors (TLR) and NOD-like receptor (NLR) polymorphisms and lipid and glucose metabolism

Cited by 23 publications

References 43 publications

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Unraveling Host-Gut Microbiota Dialogue and Its Impact on Cholesterol Levels

Physiological and Pathological Roles of Mammalian NEK7

Metabolic regulation of inflammasomes in inflammation

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