Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy

Satoh, Mamoru; Akatsu, Tomonari; Ishikawa, Yuh; Minami, Yoshitaka; Takahashi, Yūji; Nakamura, Motoyuki

doi:10.1016/j.ahj.2007.05.010

Cited by 28 publications

(12 citation statements)

References 25 publications

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“…It has been shown that TLR8 expression may be involved in the immune response to enterovirus (EV) replication in EV-associated dilated cardiomyopathy (DCM). In addition, TLR8 may provide important prognostic information in patients with EV-associated DCM [15,16]. Cheng et al investigated whether TLR8 Met1Val and TLR8 −129G>C SNPs were asoosiated with coronary artery disease (CAD) in Chinese population [12].…”

Section: Discussionmentioning

confidence: 99%

Relationship between Toll-Like Receptor 8 Gene Polymorphisms and Pediatric Pulmonary Tuberculosis

et al. 2011

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Abstract.Objectives: Genetic variants in Toll-like receptors (TLRs) are considered a potential indicator for host susceptibility to and outcome of several infectious diseases including tuberculosis. The aim of this study was to determine whether −129 C/G and Met1Val polymorphisms of TLR8 were associated with pediatric pulmonary tuberculosis in Turkish population. Methods:The −129 C/G and Met1Val polymorphisms were studied in 124 children with pulmonary tuberculosis compared to 150 age-matched healthy control subjects. Results: We did not identify any statistically significant differences between the patients with TB and control groups with regard to the frequency of genotypes GG or G/(−), CG, and CC or C/(−); and alleles G and C at rs3764879 (p > 0.05). We found a strong association with genotype A/(−) at rs3764880 with susceptibility to pulmonary TB in males (OR 2.87, 95%CI 1.38-5.98, p = 0.007). Conclusions: Our results provide evidence, for the first time, of a role for the TLR8 gene in susceptibility to pulmonary TB in male children. Additional research to verify our results are necessary. Tuberculosis in children presents particularly difficult challenges, but research priorities and advances in pediatric tuberculosis could provide wider insights and opportunities for tuberculosis control.

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Section: Discussionmentioning

confidence: 99%

Relationship between Toll-Like Receptor 8 Gene Polymorphisms and Pediatric Pulmonary Tuberculosis

et al. 2011

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“…229 Studies of the relationship between TLRs and cardiac remodeling also revealed a close correlation of TLR8 with dilated cardiomyopathy and the resultant heart failure. 230 In addition, cardiac myosin has been found serving as a direct endogenous ligand of TLR2 and TLR8 to trigger production of proinflammatory cytokines, and thereby promote inflammatory response in the myocardium and enhance cardiac remodeling. 231 In the pressure overload-or Ang II-induced cardiac hypertrophy, however, the exact ligands of TLRs have not been clearly identified.…”

Section: Upstream Irf Signaling In Cardiac Remodelingmentioning

confidence: 99%

Interferon Regulatory Factor Signalings in Cardiometabolic Diseases

Zhang

2015

Hypertension

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“…For MYD88 and JAK-2, we used primers and probes as published earlier. 21,22 Primer and hybridization probes for real-time PCR for bcr-abl and GAPDH were published previously. 20 Quantification of RNA transcript expression was normalized determining the ratio between expression levels of targets and GAPDH.…”

Section: Leukemia Cell Linesmentioning

confidence: 99%

Improved outcome of hematopoietic SCT in patients with homozygous gene variant of Toll-like receptor 9

Elmaagacli

Koldehoff

Beelen

2009

Bone Marrow Transplant

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Toll-like receptor 9 (TLR9) is part of the innate immune system, which is activated by CpG oligonucleotides (ODNs) and produces potent Th1-type innate and adaptive immune responses. It is reported that TLR9 gene variants, T1486C and T1237C, are associated with a reduced TLR9 expression compared with the wild-type gene. In two cohort analyses, we evaluated the influence of these gene variants on the outcome of transplant in 413 patients and donors. A retrospective analysis of the first cohort (n=293) showed that the homozygous CC gene variant of TLR9 (1486) compared with TC/TT gene variants was significantly associated with a markedly improved 5-year TRM (11.7 versus 36.4%, P<0.003), 5-year OS (86.1 vs 48.3%, P<0.001) and a lower relapse rate (13.2 vs 33.3%, P<0.007), whereas the occurrence of acute GVHD was not different. A prospectively performed analysis of the second cohort (n=120) and multivariate analyses confirmed the influence of the CC gene variant on these end points. Compared with patients with TC/TT gene at position 1486 of TLR9, patients with the homozygous CC gene variant had a lower TLR9 mRNA expression and a delayed T-cell immune reconstitution after transplant, which might prevent them from overwhelming immune responses as sepsis or systemic inflammatory response syndrome (SIRS) associated with an increased TRM. In vitro studies using CpG-rich ODNs showed an upregulation of TLR9 expression in cell lines with CC gene variant, but not in cell lines with wild-type gene.

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Association between toll-like receptor 8 expression and adverse clinical outcomes in patients with enterovirus-associated dilated cardiomyopathy

Cited by 28 publications

References 25 publications

Relationship between Toll-Like Receptor 8 Gene Polymorphisms and Pediatric Pulmonary Tuberculosis

Relationship between Toll-Like Receptor 8 Gene Polymorphisms and Pediatric Pulmonary Tuberculosis

Interferon Regulatory Factor Signalings in Cardiometabolic Diseases

Improved outcome of hematopoietic SCT in patients with homozygous gene variant of Toll-like receptor 9

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