Association between the XRCC3 T241M polymorphism and risk of cancer: Evidence from 157 case–control studies

The association of CD28 polymorphism, rs3116496, with Cancer: A meta-analysis

“…However, the decrease in cancer in Asians would not solely be attributed to higher T allele frequency, since there are other factors affecting cancer. Similar ethnic differences have been observed in other meta-analyses and may result from interactions between genetic and environmental or cultural factors [6,61,62]. Given the small number of studies and sample sizes included in this analysis, a large-scale study with a broader representation of ethnicities is required to assess the effect of ethnic differences in this polymorphism on cancer.…”

Association of XRCC3 Thr241Met Polymorphisms and Gliomas Risk: Evidence from a Meta-analysis

“…Generally, elevated r risk of XRCC3 Thr241Met polymorphism has been found in breast cancer, bladder cancer, colorectal cancer and deceased risk of this polymorphism found only in skin cancer (He et al, 2013). No significant association was found in other cancers such as lung cancer, head and neck cancer, melanoma, leukemia, gastric cancer, ovarian cancer or prostate cancer (He et al, 2013).…”

Association between the XRCC3 Thr241Met Polymorphism and Breast Cancer Risk: an Updated Meta-analysis of 36 Case-control Studies

“…Attention has been also drawn upon the association of Thr241Met with breast cancer risk at a meta-analytical level (Han et al, 2006;Lee et al, 2007;Economopoulos and Sergentanis, 2010;He et al, 2012;He et al, 2013); the most recent meta-analysis on the field has reported that XRCC3 T241M polymorphism is associated with increased cancer risk when all studies were pooled together. But the results remain controversial rather than conclusive.…”