Association between the triglyceride-glucose index and abdominal aortic calcification in adults: A cross-sectional study

Chen, Yuxiong; Chang, Zhen’ge; Zhao, Yakun; Liu, Yanbo; Jia, Fu; Zhang, Yongqiao; Liu, Yijie; Fan, Zhongjie

doi:10.1016/j.numecd.2021.04.010

Cited by 23 publications

(20 citation statements)

References 51 publications

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“…Additionally, it has been also revealed that TyG index is significantly associated with vascular calcification ( 33 , 34 ) and arterial stiffness ( 35 ), both of which are indicators of atherosclerosis and important for early prediction of cardiovascular disease. Moreover, former studies have also demonstrated that individuals with a higher level of TyG index were often exhibited to be more likely to combine with various traditional risk factors for cardiovascular disease including diabetes ( 10 ), prediabetes ( 11 ), hypertension ( 12 , 36 ), renal dysfunction ( 37 ), and hyperuricemia ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Zhao

Liu²,

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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BackgroundTriglyceride-glucose (TyG) index, a novel surrogate marker of insulin resistance, has been demonstrated to be significantly associated with cardiovascular disease. It remains indistinct regarding the association between TyG index and non-culprit coronary plaque characteristics in patients following acute coronary syndrome (ACS).MethodsThe present study retrospectively recruited patients who were diagnosed with ACS and underwent non-culprit optical coherence tomography (OCT) examination. The study population was divided into 2 groups based on the median of TyG index, which was calculated as Ln [fasting triglyceride (TG) (mg/dL) × fasting blood glucose (FBG) (mg/dL)/2]. The non-culprit plaque characteristics were determined by interpreting OCT images in accordance with the standard of previous consensus.Results110 patients (54.8 ± 12.1 years, 24.5% female) with 284 non-culprit plaques were included in the current analysis. TyG index was closely associated with high-risk plaque characteristics. Elevated TyG index was consistent to be an independent indicator for thin-cap fibroatheroma (TCFA) [odds ratio (OR) for per 1-unit increase 4.940, 95% confidence interval (CI) 1.652–14.767, P = 0.004; OR for taking lower median as reference 2.747, 95% CI 1.234–7.994, P = 0.011] and ruptured plaque (OR for per 1–unit increase 7.065, 95% CI 1.910–26.133, P = 0.003; OR for taking lower median as reference 4.407, 95% CI 1.208–16.047, P = 0.025) in fully adjusted model. The predictive value of TyG index for TCFA and ruptured plaque was moderate–to–high, with the area under the receiver operating characteristic curve (AUC) of 0.754 and 0.699 respectively. The addition of TyG index into a baseline model exhibited an incremental effect on the predictive value for TCFA, manifested as an increased AUC (0.681, 95% CI 0.570–0.793 vs. 0.782, 95% CI 0.688–0.877, P = 0.042), and significant continuous net reclassification improvement (0.346, 95% CI 0.235–0.458, P < 0.001) and integrated discrimination improvement (0.221, 95% CI 0.017–0.425, P = 0.034). TyG index failed to play an incremental effect on predicting ruptured plaque.ConclusionTyG index, which is simply calculated from fasting TG and FBG, can be served as an important and independent risk predictor for high-risk non-culprit coronary plaques in patients following ACS.

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Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Zhao

Liu²,

Zhao³

et al. 2022

Front. Cardiovasc. Med.

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“…Potential covariates may confound the association between BLL and AAC were summarized in our multivariable-adjusted models based on previous studies (26,(30)(31)(32). Continuous variables in our study included age, systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine, serum cotinine, hemoglobin A1c, serum uric acid, serum calcium, serum phosphorus, total cholesterol, and total 25hydroxyvitamin D. Categorical variables included gender, race, education level, body mass index (BMI), hypertension, and diabetes.…”

Section: Covariatesmentioning

confidence: 99%

Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Zheng

et al. 2021

Front. Cardiovasc. Med.

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Aims: This study aimed to evaluate the association between blood lead level (BLL) and abdominal aortic calcification (AAC) in US adults aged ≥40 years.Methods: We obtained data from 2013 to 2014 National Health and Nutrition Examination Survey (NHANES). Participants missing the data of BLL and AAC scores were excluded. BLL was measured using inductively coupled plasma mass spectrometry directly. AAC scores were quantified by Kauppila score system, and severe AAC was defined as AAC score >6. Weighted multivariable regression analysis and subgroup analysis were conducted to explore the independent relationship between BLL with AAC score and severe AAC.Results: A total of 1,530 participants were included with the mean BLL of 1.45 ± 1.31 ng/dl and mean AAC score of 1.40 ± 3.13. The prevalence of severe AAC was 7.98% overall, and participants in higher BLL quartile showed higher prevalence of severe AAC (Quartile 1: 3.55%, Quartile 2: 7.28%, Quartile 3: 9.88%, Quartile 4: 12.58%, P < 0.0001). BLL was positively associated with higher AAC score (β = 0.15, 95% CI: 0.02, 0.27, P = 0.021) and increased risk of severe AAC (OR = 1.11; 95% CI: 1.00–1.22; P = 0.047). Subgroup analysis and interaction test indicated that the association between BLL and AAC was similar in different population settings.Conclusions: Higher BLL was associated with higher AAC score and increased risk of severe AAC. Lead burden should be considered for people with AAC in clinical settings.

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“…Arterial stiffness and CAC are well-known risk factors for cardiovascular events, such as myocardial infarction [ 12 ] or stroke [ 13 ]. For example, Wu et al [ 14 ] concluded that participants with a higher TyG index should be aware of the subsequent risk of arterial stiffness progression, and an independent association between the TyG index and extensive abdominal aortic CAC was found by Chen et al [ 15 ]. These findings suggest that the TyG index may serve as a marker independent of traditional risk factors for arterial stiffness and CAC.…”

Section: Introductionmentioning

confidence: 99%

Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis

Liu

Ling

Xie

et al. 2023

Cardiovasc Diabetol

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Background The triglyceride and glucose (TyG) index has been linked to various cardiovascular diseases. However, it's still unclear whether the TyG index is associated with arterial stiffness and coronary artery calcification (CAC). Methods We conducted a systematic review and meta-analysis of relevant studies until September 2022 in the PubMed, Cochrane Library, and Embase databases. We used a random-effects model to calculate the pooled effect estimate and the robust error meta-regression method to summarize the exposure-effect relationship. Results Twenty-six observational studies involving 87,307 participants were included. In the category analysis, the TyG index was associated with the risk of arterial stiffness (odds ratio [OR]: 1.83; 95% CI 1.55–2.17, I2 = 68%) and CAC (OR: 1.66; 95% CI 1.51–1.82, I2 = 0). The per 1-unit increment in the TyG index was also associated with an increased risk of arterial stiffness (OR: 1.51, 95% CI 1.35–1.69, I2 = 82%) and CAC (OR: 1.73, 95% CI 1.36–2.20, I2 = 51%). Moreover, a higher TyG index was shown to be a risk factor for the progression of CAC (OR = 1.66, 95% CI 1.21–2.27, I2 = 0, in category analysis, OR = 1.47, 95% CI 1.29–1.68, I2 = 41% in continuity analysis). There was a positive nonlinear association between the TyG index and the risk of arterial stiffness (Pnonlinearity < 0.001). Conclusion An elevated TyG index is associated with an increased risk of arterial stiffness and CAC. Prospective studies are needed to assess causality. Graphical Abstract

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Association between the triglyceride-glucose index and abdominal aortic calcification in adults: A cross-sectional study

Cited by 23 publications

References 51 publications

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Triglyceride-glucose index and non-culprit coronary plaque characteristics assessed by optical coherence tomography in patients following acute coronary syndrome: A cross-sectional study

Higher Blood Lead Level Is Associated With Increased Likelihood of Abdominal Aortic Calcification

Association between triglyceride glucose index and arterial stiffness and coronary artery calcification: a systematic review and exposure-effect meta-analysis

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